Height and sexual maturation in girls with juvenile idiopathic arthritis

Machado, Sandra Helena; Xavier, Ricardo Machado; Lora, Priscila Schmidt; Gonçalves, Luciana Machado Kurtz; Trindade, Luciane R.; Maróstica, Paulo José Cauduro

doi:10.1016/j.jped.2018.07.015

Cited by 9 publications

(4 citation statements)

References 28 publications

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“…A cross-sectional study, involving girls with JIA, showed that patients with polyarticular JIA and higher cumulative glucocorticoid doses more likely had a short stature. This study suggests that, even six months after glucocorticoid treatment interruption, children with polyarticular or systemic JIA are still inclined to short stature and delayed puberty [28].…”

Section: Growth Delay and Short Staturementioning

confidence: 69%

“Neuroimmunoendocrinology” in Children with Rheumatic Diseases: How Glucocorticoids Are the Orchestra Director

Maggio,

Miniaci,

Gallizzi

et al. 2023

IJMS

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The neural, the endocrine, and the immune systems are studied as distinct districts in physiological and pathological settings. However, these systems must be investigated with an integrative approach, while also considering that therapeutic agents, such as glucocorticoids, can induce a reversible or irreversible change of this homeostasis. Children and adolescents affected by rheumatic diseases frequently need treatment with corticosteroids, and the treatment must sometimes be continued for a long time. In the biological era, the treat-to-target strategy allowed a real revolution in treatment, with significant steroid dose sparing or, in many patients, steroid treatment withdrawal. In this review, the impact of glucocorticoids on endocrine, immune, and neurologic targets is analyzed, and the crosstalk between these systems is highlighted. In this narrative review, we explore the reasoning as to why glucocorticoids can disrupt this homeostasis, we summarize some of the key results supporting the impact of glucocorticoids treatment on endocrine, immune, and neurologic systems, and we discuss the data reported in the international literature.

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Section: Growth Delay and Short Staturementioning

confidence: 69%

“Neuroimmunoendocrinology” in Children with Rheumatic Diseases: How Glucocorticoids Are the Orchestra Director

Maggio,

Miniaci,

Gallizzi

et al. 2023

IJMS

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“…A Artrite Idiopática Juvenil (AIJ) é um grupo heterogêneo de doenças da infância que engloba artrite de causa desconhecida com pelo menos seis semanas de duração e com início antes dos 16 anos 5 . É, portanto, uma enfermidade crônica, inflamatória e mediada por várias citocinas (interleucina 6, fator de necrose tumoral alfa -TNF -, interleucina 1 beta) que podem afetar o organismo todo 6 .…”

Section: Resultsunclassified

“…Por fim, a AIJ pode causar retardo do crescimento pelo elevado processo inflamatório (algumas citocinas liberadas reduzem a liberação hipofisária do hormônio do crescimento, o GH) e pelo uso prolongado de glicocorticoides (inibem o crescimento ósseo agindo diretamente na placa de crescimento). A baixa estatura e índice de massa corporal estão diretamente associados à forma poliarticular da AIJ e a uma dose cumulativa maior de glicocorticoides, além de que tais medicamentos ainda podem comprometer e atrasar a maturação sexual 6 .…”

Section: Resultsunclassified

Artrite Idiopática Juvenil: um estudo sistemático acerca da terapia farmacológica

Rodrigues Pereira,

Rodrigues,

Camapum

et al. 2024

Braz. J. Implantol. Health Sci.

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O objetivo deste artigo é elucidar, através da literatura, a eficácia, os benefícios, adesão e limitações do tratamento medicamentoso da Artrite Idiopática Juvenil. Para que isso fosse possível, foi realizada uma revisão sistemática, utilizando a base de dados PubMed, selecionando artigos científicos confiáveis e atualizados, publicados entre os anos de 2014 e 2024. Através do presente estudo, foi possível concluir que a artrite idiopática juvenil é um grupo heterogêneo de doenças que pode comprometer a qualidade de vida dos pacientes. Portanto, seu tratamento deve ser multifatorial e pensado de acordo com o contexto clínico de cada paciente, nos efeitos adversos das medicações e no perfil social e na adesão terapêutica.

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“…Another study published in 2020 reported that patients with poly and systemic JIA who received six months of relatively short-term glucocorticoid treatment were prone to low weight and delayed puberty. 20 Malnutrition, obesity, hirsutism, adrenal suppression, osteoporosis, which are not included in the JADI-E score, were also evaluated in our study. All of these complications are associated with steroid therapy.…”

Section: Discussionmentioning

confidence: 99%

Assesment of Damage in Juvenile Idiopathic Arthritis: Single Center Experience

Asadova¹,

Kısaarslan²,

Çiçek³

et al. 2022

JPA

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Introduction:It is essential to evaluate the activation and the articular and extra-articular damage during the Juvenile Idiopathic Arthritis(JIA) disease course. Objectives:This study aimed to evaluate the damage status and affecting factors in JIA patients. Methods:Juvenile Arthritis Damage Index articular(JADI-A) and extra-articular(E) were evaluated in 204 JIA patients who had been followed up for two years andmore. JADI-A and E affecting factors were assessed by univariate and multivariate logistic regression analysis. Results: In this study,127(62.6%) of the patients were female. The median age was 13(IQR: 11-16), and the age at diagnosis was 7(IQR: 4-10) years. The median follow-up time was 5(IQR: 4-8) years. Ninety-two(45.3%) patients had comorbid diseases. JADI-A were median:0(min-max: 0-24), JADI-E were median:0(min-max:0-4).The annual attacks number [OR:1,759 (CI:1,300-2,379],p:<0,001),annual eritrocyte sedimantation rate (ESR) [OR:1,072(CI:1,021-1,125),p:0.005] were effective on JADI-A scores. The CRP at the first admission [OR:1.007(CI: 1,000-1,014), p:0.037], the annual ESR[OR:1,051(CI:1,008-1,095),p:0.019] were found to be effective on the JADI-E. The ideal cut-off point of the attacks number and ESR affecting JADI-A scores were 1.38[AUC:0.734(0.641-0.828),p:0.001] and 14.32[AUC:0.617(0.514-0.721),p:0.027], respectively. The ideal cut-off point of the CRP and ESR affecting JADI-E scores were 13,25[AUC:0,662(0,541-0,782),p:0,009],and15,10[AUC:0.674(0.567-0.780),p:0.002], respectively. Steroid related complications such as, obesity in 12 (5.9%), hirsutism in 3 (1.5%), transient adrenal suppression in 14 (6.9%), 8 (3.9%), and osteoporosis were detectedin 7 (3.4%) patients. Conclusion: We have shown that parameters used routinely can be helpful to predict damage. We also think that new criteria should be added to the scoring.

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Height and sexual maturation in girls with juvenile idiopathic arthritis

Cited by 9 publications

References 28 publications

“Neuroimmunoendocrinology” in Children with Rheumatic Diseases: How Glucocorticoids Are the Orchestra Director

“Neuroimmunoendocrinology” in Children with Rheumatic Diseases: How Glucocorticoids Are the Orchestra Director

Artrite Idiopática Juvenil: um estudo sistemático acerca da terapia farmacológica

Assesment of Damage in Juvenile Idiopathic Arthritis: Single Center Experience

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