Radiographic predictors determined with an objective assessment tool for neonatal patients with necrotizing enterocolitis

Alves, Allan Felipe Fattori; Pavan, Ana Luiza Menegatti; Giacomini, Guilherme; Quini, Caio C.; Ribeiro, Sérgio Marrone; Marquez, Rozemeire Garcia; Bentlin, Maria Regina; Trindade, André Petean; Miranda, José Ricardo de Arruda; Pina, Diana Rodrigues de

doi:10.1016/j.jped.2018.05.017

Cited by 2 publications

(2 citation statements)

References 31 publications

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“…Once NEC is suspected, the NB must undergo a regular routine of abdominal radiography that aims to monitor the progression of the disease and guide clinical management. The timing of follow-up abdominal radiographs depends on the severity of the NEC and ranges from 6 to 24 h. This follow-up helps to indicate the need for surgical intervention 1 , 9 , 18 , 19 . The protocol was rigorously followed in the conduct of the cases in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Radiological signs of NEC include localized bowel distension, generalized bowel distension, bowel wall thickening, intestinal pneumatosis, air in the hepatic portal venous system, and pneumoperitoneum. However, even with these predictors, diagnosing NEC is a very difficult task for physicians 1 , 9 , 18 , 19 . Studies have been carried out to better understand the etiology of NEC and ways to prevent its progression; however, few have resulted in significant results that have led to changes in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

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Is -94ins/Delattg Polymorphism in the Nuclear Factor Kappa-B1 Gene (Nfkb1) Associated With Necrotizing Enterocolitis?

Ferdinando

Fraga

Piatto

et al. 2022

ABCD, arq. bras. cir. dig.

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BACKGROUND: Abnormalities in the different stages of the intestinal maturation process cause metabolic and molecular changes. Among the genetic alterations associated with necrotizing enterocolitis, the -94ins/delATTG polymorphism in NFKB1 gene leads to unregulated activation of the NFKB protein due to an increase in the inherent pro-inflammatory state of the premature intestine. AIMS:To determine the prevalence of the -94ins/delATTG polymorphism in NFKB1 gene in neonates with and without necrotizing enterocolitis. METHODS:This is a case-control study, in which 25 neonates were evaluated as the case group and 50 neonates as the control group, of both genders. DNA was extracted from peripheral blood leukocytes, and the site encompassing the polymorphism was amplified by molecular techniques (polymerase chain reaction/polymorphism in restriction fragment length). RESULTS:Necrotizing enterocolitis was diagnosed in 25 (33%) neonates and, of these, 3 (12%) died. Male gender was more prevalent in both groups (p=0.1613): cases (52%) and controls (62%). Moderate and extreme preterm newborns were predominant in both groups: cases (80%) and controls (88%) (p=0.3036). Low birth weight and extremely low birth weight newborns were the most prevalent in cases (78%), and very low birth weight and extremely low birth weight were the most prevalent in controls (81%) (p=0.1073). Clinical treatment was successful in 72%, and hospital discharge was achieved in 88% of newborns with NEC. The -94ins/delATTG polymorphism in NFKB1 gene was not identified in all the 150 alleles analyzed (100%). CONCLUSIONS:The absence of the -94ins/delATTG polymorphism in NFKB1 gene in newborns with and without necrotizing enterocolitis does not rule out the possibility of alterations in this and/or in other genes in newborns with this condition, which reinforces the need for further research.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Is -94ins/Delattg Polymorphism in the Nuclear Factor Kappa-B1 Gene (Nfkb1) Associated With Necrotizing Enterocolitis?

Ferdinando

Fraga

Piatto

et al. 2022

ABCD, arq. bras. cir. dig.

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In-hospital outcomes in preterm and small-for-gestational-age newborns: a cohort study

Costa

Valete³

et al. 2022

Einstein (São Paulo)

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Objective: To compare in-hospital outcomes between small-for-gestational-age and appropriatefor-gestational-age preterm neonates who needed intensive care. Methods: A retrospective cohort study with preterm newborns, from January to December 2017. The results are presented as median, frequency, and odds ratio. Numerical variables were compared using the Wilcoxon test. Categorical variables were compared using the χ 2 test. We considered p<0.05 as significant. Results: Out of 129 preterm newborns included, 20.9% were small-for-gestationalage. Median gestational age was 31 2/7 weeks, birthweight was 1,450g, and length of hospital stay was 39 days. Preterm small-for-gestational-age newborns presented a higher chance of peri-intraventricular hemorrhage (odds ratio of 3.23; p=0.02), retinopathy of prematurity (odds ratio of 2.78 p=0.02), patent ductus arteriosus (odds ratio of 2.50; p=0.04) and a lower chance of presumptive early-onset sepsis (odds ratio of 0.37; p=0.03). Conclusion: Preterm small-forgestational-age neonates were associated with peri-intraventricular hemorrhage, retinopathy of prematurity and patent ductus arteriosus. This emphasizes the need of special care for these neonates.

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Radiographic predictors determined with an objective assessment tool for neonatal patients with necrotizing enterocolitis

Cited by 2 publications

References 31 publications

Is -94ins/Delattg Polymorphism in the Nuclear Factor Kappa-B1 Gene (Nfkb1) Associated With Necrotizing Enterocolitis?

Is -94ins/Delattg Polymorphism in the Nuclear Factor Kappa-B1 Gene (Nfkb1) Associated With Necrotizing Enterocolitis?

In-hospital outcomes in preterm and small-for-gestational-age newborns: a cohort study

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