Do infants with cow's milk protein allergy have inadequate levels of vitamin D?

Silva, Cristiane M.; Silva, Silvia A. da; Antunes, Margarida Maria de Castro; Silva, Gisélia Alves Pontes da; Sarinho, Emanuel Sávio Cavalcanti; Brandt, Kátia Galeão

doi:10.1016/j.jped.2017.01.006

Cited by 19 publications

(14 citation statements)

References 25 publications

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“…Previous studies have indicated a heightened risk of low serum 25(OH)D in patients with CMPA that are breastfed and not on fortified hypoallergenic formulas [10,[34][35]. Surprisingly, in our study, partially breastfeeding children did not have significantly lower serum 25(OH)D levels than peers on hypoallergenic formulas.…”

Section: Breastfeeding Status and Vitamin D Supplementationcontrasting

confidence: 84%

“…The reported (80.8%) and actual (44.4%) rates of adherence to VDS among children with CMPA in Ireland fell within the range reported by previous studies [10,39,40] among children ≤ 24 months of age. National recommendations seem to play a limited role in encouraging VDS use.…”

Section: Vitamin D Supplementation Among Children With Cmpa In Irelandsupporting

confidence: 79%

“…The Institute of Medicine's serum 25(OH)D classification [9], adopted in this study, considers levels <30 nmol/L deficient and levels between 30 and 50 nmol/L insufficient (Table 2). In general, low serum 25(OH)D levels in children can arise from low dietary intake, inadequate sun exposure, lack of supplementation and maternal hypovitaminosis [10]. In early childhood, however, cow's milk consumption and vitamin D supplements (VDS) are thought to be the greatest determinants of serum 25(OH)D status [11].…”

Section: Vitamin D Insufficiency/deficiency In Cmpamentioning

confidence: 99%

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Vitamin D Status in Cow’s Milk Protein Allergy

Pandiaraja

Maris

2020

URNCST Journal

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Introduction: Cow's milk protein allergy (CMPA) affects 1.9 -4.9% of children worldwide and can be IgE-mediated or non-IgE mediated. Studies have highlighted the increased risk of inadequate vitamin D intake in children with CMPA on elimination diets, with potential effects on bone health, respiratory health and immune function. This study aims to investigate whether children with CMPA are at a higher risk of vitamin D insufficiency than their healthy counterparts. Methods: This was an observational, cross-sectional study carried out at the specialist Paediatric Allergy Clinic, Bon Secours Hospital Cork and the Department of Paediatrics, Bon Secours Hospital Cork. 52 children with CMPA and 26 healthy controls, aged 6 to 24 months, were included. Exclusion criteria included known bone metabolism disorders, chronic renal and gastrointestinal disorders, and chronic infectious diseases. A retrospective chart review of children with CMPA was conducted to collect data on patient demographics, clinical presentation, and management. Serum 25(OH)D levels of children with CMPA (n=18) and healthy controls (n=26) were quantified and compared. Caregivers of children with CMPA were administered an online questionnaire to assess compliance to vitamin D supplementation. Results: The serum 25(OH)D levels of children with CMPA were significantly lower than that of healthy controls (47.5 vs 62.5 nmol/L, p = 0.030). Among children with CMPA, children with IgE-mediated CMPA (p=0.041) and children with multiple concomitant IgE-mediated food allergies (p=0.011) had significantly lower serum 25(OH)D levels than their healthy counterparts. Among children with CMPA, breastfeeding status, reported vitamin D supplement use, age and gender were not significantly associated with serum 25(OH)D levels. The questionnaire revealed only 44.4% of caregivers to be fully adherent to vitamin D supplementation guidelines. Conclusion: Children with CMPA are at higher risk of serum 25(OH)D insufficiency than healthy controls. Closer monitoring is required to ensure that vitamin D supplements are administered from birth to 12 months, at the recommended frequency.

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Section: Breastfeeding Status and Vitamin D Supplementationcontrasting

confidence: 84%

Section: Vitamin D Supplementation Among Children With Cmpa In Irelandsupporting

confidence: 79%

Section: Vitamin D Insufficiency/deficiency In Cmpamentioning

confidence: 99%

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Vitamin D Status in Cow’s Milk Protein Allergy

Pandiaraja

Maris

2020

URNCST Journal

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“…The role of genetics in resistance vs. susceptibility to develop sesame allergies needs to be determined. Knowledge about what kind of environmental factors favor development of sesame allergy are largely unknown [97][98][99][100][101][102][103][104][105].…”

Section: How To Advance the Basic Preclinical And Clinical Researchmentioning

confidence: 99%

“…Several exposure conditions (e.g., environmental toxicants, triclosan, parabens, food preservatives, misuse of antibiotics, Vitamin D deficiency, sunlight exposure, dog ownership, excess use of antacids etc.,) that are currently being explored for other food allergies should provide the starting points of research [97][98][99][100][101][102][103][104][105].…”

Section: How To Advance the Basic Preclinical And Clinical Researchmentioning

confidence: 99%

The Global Rise and the Complexity of Sesame Allergy: Prime Time to Regulate Sesame in the United States of America?

Gangur

Acharya

2020

Allergies

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Sesame allergy is a life-threatening disease that has been growing globally with poorly understood mechanisms. To protect sensitive consumers, sesame is regulated in many countries. There were four research goals for this work on sesame allergy: (i) to map the timeline, and the extent of its global rise; (ii) to dissect the complexity of the disease, and its mechanisms; (iii) to analyze the global regulation of sesame; and (iv) to map the directions for future research and regulation. We performed a literature search on PubMed and Google Scholar, using combinations of key words and analyzed the output. Regulatory information was obtained from the government agencies. Information relevant to the above goals was used to make interpretations. We found that: (i) the reports appeared first in 1950s, and then rapidly rose globally from 1990s; (ii) sesame contains protein and lipid allergens, a unique feature not found in other allergenic foods; (iii) it is linked to five types of diseases with understudied mechanisms; and (iv) it is a regulated allergen in 32 advanced countries excluding the USA. We also provide directions for filling gaps in the research and identify implications of possible regulation of sesame in the USA.

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Nutritional Management of Children with Food Allergies

Wright

Feeney

Yerlett

2022

Curr Treat Options Allergy

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Purpose of the Review The purpose of the review is to review the evidence for the nutritional management of paediatric food allergy and provide a practical approach for healthcare professionals working in this area. Recent Findings Dietary elimination remains the mainstay for management of food allergies in children. However, the elimination of food allergens increases the risk for growth faltering, micronutrient deficiencies and feeding difficulties. Breastmilk remains the ideal source of nutrition for infants, but when not available, the vast majority will tolerate an extensively hydrolysed formula, and rice hydrolysate has also been suggested as a suitable alternative. Only in severe cases, including anaphylaxis, eosinophilic oesophagitis and growth faltering, is an amino acid formula indicated. The early introduction of peanut and egg and avoiding the delay in the introduction of other allergens, when not already allergic, has been highlighted by recent studies. Summary Whilst the elimination of allergens increases the risk of developing poor growth, micronutrient deficiencies and feeding difficulties, optimal, early dietary input, including advice on active introduction of allergens and alternative feeds, ideally from a registered dietitian/nutritionist, may be prevent and improve outcomes.

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Do infants with cow's milk protein allergy have inadequate levels of vitamin D?

Abstract: Lower vitamin D levels were found in infants with CMPA, especially those who were exclusively or predominantly breastfed, making these infants a possible risk group for vitamin D deficiency.

Cited by 19 publications

References 25 publications

Vitamin D Status in Cow’s Milk Protein Allergy

Vitamin D Status in Cow’s Milk Protein Allergy

The Global Rise and the Complexity of Sesame Allergy: Prime Time to Regulate Sesame in the United States of America?

Nutritional Management of Children with Food Allergies

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