Autism in 2016: the need for answers

Posar, Annio; Visconti, Paola

doi:10.1016/j.jped.2016.09.002

Cited by 50 publications

(30 citation statements)

References 43 publications

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“…Расстройства аутистического спектра (РАС) представляют собой группу дезинтегративных нарушений психического развития, характеризующихся отсутствием способности к социальному взаимодействию, коммуникации, стереотипностью поведения, приводящих к социальной дезадаптации. По современным эпидемиологическим данным, распространенность РАС составляет около 1% в детской популяции [1][2][3]. Соотношение частоты аутистических расстройств у мальчиков и девочек составляет 4:1 [4].…”

Section: © коллектив авторов 2017unclassified

The efficacy of cerebrolysin in the treatment of autism spectrum disorders

Чутко

Yakovenko

Surushkina

et al. 2017

Z. nevrol. psikhiatr. im. S.S. Korsakova

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In children with exogenous (organic) autism, the lower scores of autistic symptom on the CARS and a greater degree of functional immaturity of the cerebral cortex, according to electroencephalographic results, were found compared to children with endogenous autism. After treatment with cerebrolysin, 27 children (62.8%) showed signs of improvement. An improvement was noted in 13 children in with endogenous autism (56.5%) and in 14 children with organic autism (70.0%). CARS scores showed a more pronounced decrease in this indicator in a subgroup of children with organic autism.

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Section: © коллектив авторов 2017unclassified

The efficacy of cerebrolysin in the treatment of autism spectrum disorders

Чутко

Yakovenko

Surushkina

et al. 2017

Z. nevrol. psikhiatr. im. S.S. Korsakova

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“…3 Despite the complex etiopathogenesis of this disease, the current literature has already established that its development is linked to a series of genetic, metabolic and environmental factors that, when connected, become a kind of trigger, sparking the disease. 4,5 Among the factors involved in the genesis of ASD, some nutritional variables have been studied, such as vitamin D deficiency and intestinal dysbiosis. [5][6][7] Although they are not included in the set of behavioral changes characteristic of autism, inadequate manifestations related directly or indirectly to food are also present in 30 to 90% of the cases, the most common being food selectivity and gastrointestinal changes (constipation, diarrhea, pain abdominal disease, inflammatory bowel disease, celiac disease, food intolerance).…”

Section: Introductionmentioning

confidence: 99%

Excess Weight and Gastrointestinal Symptoms in a Group of Autistic Children

Silva

Santos

Silva

2020

Rev. paul. pediatr.

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Objective: To evaluate the nutritional status and gastrointestinal changes in children with autism spectrum disorder (ASD). Methods: Cross-sectional, descriptive analysis of 39 children with ASD aged between three and ten years old, registered in the participating association. Nutritional status was evaluated by body mass index/age and weight/age, according to the guidelines from the World Health Organization. In order to investigate whether gastrointestinal alterations occurred, the interviewees answered a questionnaire about the presence of these symptoms within the last 30 days. In order to evaluate food consumption, a 24-hour recall questionnaire was applied and the food reported were grouped as: gluten sources, casein and ultra-processed sources. For the statistical analysis, Epi-Info software version 7.2 was used. Multivariate logistic regression analysis was performed to evaluate the variables associated with gastrointestinal alterations. Results: There was a high prevalence of overweight children with autism spectrum disorder (64.1%). No child was underweight. Thirty-four children (84.2%) had gastrointestinal symptoms. Consumption of gluten was associated with gastrointestinal symptoms (β=0.38; 95%CI 0.07-0.75; p=0.02). Conclusions: The high prevalence of being overweight should be considered during the follow-up visits of children with ASD. The influence of gluten consumption on the presence of gastrointestinal symptoms was observed in this study, and the causes involved in these alterations need to be further investigated.

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“…In this paper we addressed the hypothesis of a possible connection between narcolepsy and autism spectrum disorder (ASD), whose main clinical features are early-onset impairments of social communication abilities and the presence of repetitive interests and activities (6). In recent decades, the marked increase in ASD prevalence, which has reached 16.8 per 1,000 children aged 8 years according to a multicenter study in the United States 7, highlights the importance also of possible environmental factors such as pollutants in the etiopathogenesis of this disorder, in addition to indisputable genetic factors (8). The finding of a connection between narcolepsy and ASD, so far not adequately investigated, could boost the study of possible etiopathogenetic mechanisms shared between these two apparently so distant disorders.…”

Section: Introductionmentioning

confidence: 99%

Autism Spectrum Disorder and Narcolepsy: A Possible Connection That Deserves to Be Investigated

et al. 2020

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Narcolepsy in childhood-adolescence is characterized by a high occurrence of psychiatric comorbidities. The most frequent psychiatric disorders reported in these patients are attention deficit/hyperactivity disorder, depression, anxiety disorder, and schizophrenia. However, narcolepsy can be associated also with introversion, sorrowfulness, feelings of inferiority, impaired affectivity modulation, emotional lability, irritability, aggressiveness, and poor attention, that have been pooled by some authors under a definition of "narcoleptic personality." Some aspects of this "narcoleptic personality," and in particular introversion, impaired affectivity modulation, irritability, and poor attention, partially overlap with the clinical features of the individuals with autism spectrum disorder, considering also those that are not regarded as core autism symptoms. Till now, in literature the number of cases affected by both narcolepsy and autism spectrum disorder (seven patients) has been clearly too small to demonstrate the presence of a pathogenetic link between these two conditions, but this possible connection has not yet been adequately investigated, despite the presence of several points in common. The finding of a connection between narcolepsy and autism spectrum disorder could boost the study of possible etiopathogenetic mechanisms shared between these two apparently so distant disorders. Basing on the literature data summarized in this paper, in the diagnostic work-up of a child with narcolepsy it is essential to evaluate also the social-communicative behavior using standardized tools in order to detect the real recurrence of clinical features suggesting an autism spectrum disorder. At the same time, it appears necessary to screen in the individuals with autism spectrum disorder for the possible presence of evoking symptoms of narcolepsy.

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Autism in 2016: the need for answers

Cited by 50 publications

References 43 publications

The efficacy of cerebrolysin in the treatment of autism spectrum disorders

The efficacy of cerebrolysin in the treatment of autism spectrum disorders

Excess Weight and Gastrointestinal Symptoms in a Group of Autistic Children

Autism Spectrum Disorder and Narcolepsy: A Possible Connection That Deserves to Be Investigated

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