The influence of antineoplastic treatment on the weight of survivors of childhood cancer

Teixeira, Julia Ferrari Carneiro; Maia-Lemos, Priscila Dos Santos; Cypriano, Mônica; Pisani, Luciana Pellegrini

doi:10.1016/j.jped.2016.04.003

Cited by 14 publications

(21 citation statements)

References 47 publications

(38 reference statements)

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“…Similar results were reported by Brown et al (2016), who found that a high BMI at diagnosis was associated with a high BMI at end of therapy. Also consistent with our findings, other studies reported a 12 times higher risk of obesity after therapy when they were obese at the start of therapy (Teixeira et al, 2016). In contrast, a study by Lindemulder et al (2015) showed no increased risk of overweight/obesity in survivors of standard risk ALL, compared to noncancer peers.…”

Section: Discussionsupporting

confidence: 93%

“…Likewise, other findings suggest that 48.5% of ALL survivors were prehypertensive, 22% were hypertensive, and 38.2% were overweight or obese, with more females than males being overweight/obese (Veringa et al, 2012). Finally, Inaba et al (2012) also reported females had higher body fat and lower lean body mass after bone marrow transplantation, and Teixeira et al (2016) found females receiving radiation have higher obesity rates. Conversely, Brown et al (2016) found higher obesity rates in male cancer survivors in an ethnically diverse population, and Miller et al (2010) found male survivors had higher body fat compared to sibling controls.…”

Section: Discussionmentioning

confidence: 95%

“…Research suggests that the childhood cancer survivor population is particularly at risk for obesity. Some studies have identified types of therapy (e.g., radiation, chemotherapy/type, steroid treatment) as significant predictors of obesity (Teixeira, Maia-Lemos, Cypriano, & Pisani, 2016), while others implicate lifestyle factors (i.e., high energy intake and low energy expenditure, parent permissiveness on diet and activity) as predictors (Zhang & Parsons, 2015).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Predictors of Overweight and Obesity in Childhood Cancer Survivors

Gance‐Cleveland

Arbet

Stiller

et al. 2020

J Pediatr Oncol Nurs

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Purpose: The purpose of this study was to explore the potential risk factors for overweight/obesity in survivors of childhood cancer. Design: A retrospective chart review of childhood cancer survivors ( N = 321) seen in a cancer survivor clinic was conducted to determine the strongest risks of overweight/obesity. Risk factors were as follows: age, race, gender, cancer diagnosis, body mass index at diagnosis, and treatment. Multivariate logistic regression was used to identify risks of overweight/obesity while simultaneously adjusting for other patient factors. Findings: Data suggested that female cancer survivors, Hispanics, those with higher body mass index at diagnosis, and those with longer duration of treatment had greater odds of being overweight/obese. Conclusions: Many of the risk factors for overweight/obesity in childhood cancer survivors are consistent with the general population, and length of cancer treatment is unique to this population. Implications for Nursing: Findings from this study will inform care for childhood cancer survivors to improve long-term cardiovascular health.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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Predictors of Overweight and Obesity in Childhood Cancer Survivors

Gance‐Cleveland

Arbet

Stiller

et al. 2020

J Pediatr Oncol Nurs

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“…Based on the BMI/A measures, Nakhaei-Moghadam et al [16] found a prevalence of 29.2% overweight and 16.7% obesity, and no association between patients' weight gain and type of treatment, gender and age. According to other studies the prevalence of obesity after antineoplastic treatment of ALL in childhood varies from 16% to 56% approximately, and may be related to cranial radiation, treatment with corticosteroids, physical inactivity and increased calories intake [8,21]. Our study found a higher patients' eutrophy prevalence in M3, corroborating the data from other investigations, where the patients who survived leukemias were eutrophic utilizing the same parameters as BMI/A [17].…”

Section: Discussionsupporting

confidence: 90%

“…Advances in antineoplastic treatments and in the care of children with cancer resulted in a significant increase in cancer cure rates [4]. This longer survival is accompanied by an increase in the chances of development of various late effects, such as premature mortality, osteoporosis, growth deficit, coronary artery disease, hypertension, secondary malignant neoplasms, psychosocial effects, metabolic disorders such as overweight, glucose intolerance, insulin resistance, and diabetes, due to chemotherapy and the use of high doses of corticosteroids [5][6][7][8]. Obesity in patients who survive childhood cancer may develop due to the oncological treatment itself, because of the reduction of physical activity, family-related factors, unhealthy nutrition, hormone changes and prolonged exposure to the use of corticosteroids [6,9].…”

Section: Introductionmentioning

confidence: 99%

Changes in nutritional status in adolescents surviving leukemia and lymphoma

et al. 2020

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Objective To examine the changes in the nutritional status of adolescents aged 10-19 years after a minimum 12 months interval following oncological treatment for leukemias and lymphomas. Methods Longitudinal design quantitative study conducted at Hospital de Clínicas, Porto Alegre. Adolescents aged 10-19 years after a minimum 12 months interval following oncological treatment for leukemias and lymphomas were included. The measures of weight, height, brachial circumference, triceps skinfold thickness, arm muscle circumference and abdominal circumference were collected. Results The sample comprised 50 adolescents who had survived leukemias and lymphomas. In the follow up 38% of the patients were classified as overweight according to the body mass index for their age. There was a significant increase in body mass index for age between the beginning and the end of treatment and follow up (p=0.013) in female individuals, compared to males. The results indicate a reduction in the Z-score means of height for age, with significant differences between the beginning of treatment and follow up (p=0.016); and end of treatment and follow up (p=0.006) in patients of both genders Conclusion The anthropometric indicators show an important frequency of excess weight and increased tricipital skinfold, as well as a significant increase of the body mass index for age and also a growth deficit among the survivors.

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Body composition of patients with neuroblastoma using computed tomography

IJpma

Lequin

Nievelstein

et al. 2021

Pediatric Blood & Cancer

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Background: Computed tomography (CT) is often used to investigate muscle and fat mass in adult patients with cancer. However, this method has rarely been used in the pediatric cancer population. The present retrospective study aimed to investigate changes in body composition using CT during treatment in children with neuroblastoma.Procedure: CT images of 29 patients with high-risk neuroblastoma were retrospectively analyzed at diagnosis and longitudinally during treatment. The cross-sectional area of skeletal muscle, intermuscular adipose tissue (IMAT), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) and skeletal muscle density at the level of the third lumbar vertebra were examined. To correct for height, cross-sectional areas were divided by height in meters squared. A linear mixed model was estimated to investigate changes in body composition over time.Results: A small increase in skeletal muscle (p = .029), skeletal muscle density (p = .002), and IMAT (p < .001) was found. Furthermore, a rapid increase in VAT (p < .001) and SAT (p = .001) was seen early during treatment with the highest volumes after six cycles of chemotherapy.Conclusions: CT scans obtained during standard care provide insight into the direction and timing of changes in skeletal muscle and different types of adipose tissue in childhood cancer patients. Future research is needed regarding the consequences of the rapid increase of VAT and SAT early during treatment.

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The influence of antineoplastic treatment on the weight of survivors of childhood cancer

Cited by 14 publications

References 47 publications

Predictors of Overweight and Obesity in Childhood Cancer Survivors

Predictors of Overweight and Obesity in Childhood Cancer Survivors

Changes in nutritional status in adolescents surviving leukemia and lymphoma

Body composition of patients with neuroblastoma using computed tomography

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