Microcephaly and Zika virus

Oliveira, Consuelo Silva de; Vasconcelos, Pedro Fernando da Costa

doi:10.1016/j.jped.2016.02.003

Cited by 51 publications

(40 citation statements)

References 16 publications

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“…Human flavivirus infections are responsible for significant morbidity and mortality worldwide, eliciting a spectrum of manifestations: from asymptomatic infections to mild flu‐like symptoms, or more severe complications such as encephalitis and haemorrhagic fever. Furthermore, congenital developmental deficits, and neurological syndromes have been associated with ZIKV infections, a previously neglected member of the genus (Cao‐Lormeau et al, ; de Oliveira & Da Costa Vasconcelos, ; Fauci & Morens, ; Gould & Solomon, ; Mackenzie, Gubler, & Petersen, ; Oehler et al, ; Ventura, Maia, Bravo‐Filho, Gois, & Belfort, ).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses

Cumberworth

Clark

Kohl

et al. 2017

Cellular Microbiology

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SummaryThe Flavivirus genus (Flaviviridae family) contains a number of important human pathogens, including dengue and Zika viruses, which have the potential to cause severe disease. In order to efficiently establish a productive infection in mammalian cells, flaviviruses have developed key strategies to counteract host immune defences, including the type I interferon response. They employ different mechanisms to control interferon signal transduction and effector pathways, and key research generated over the past couple of decades has uncovered new insights into their abilities to actively decrease interferon antiviral activity. Given the lack of antivirals or prophylactic treatments for many flaviviral infections, it is important to fully understand how these viruses affect cellular processes to influence pathogenesis and disease outcome. This review will discuss the strategies mosquito‐borne flaviviruses have evolved to antagonise type I interferon mediated immune responses.

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Section: Introductionmentioning

confidence: 99%

Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses

Cumberworth

Clark

Kohl

et al. 2017

Cellular Microbiology

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“…All four mothers had clinical signs of ZIKV infection during the first trimester of pregnancy, but not at the time of delivery or miscarriage[46]. Further reports in Brazil have described the presence of ZIKV RNA in fetuses and amniotic fluids[31,47,48]. Even though sporadic vertical transmission in humans has been previously reported in other members of the Flaviviridae family, such DENV[49] or YFV[50], the surprisingly high number of infants born with microcephaly in Brazil during the current outbreak, which could probably be the result of a possible vertical transmission, has urged the WHO to publish some advice for women who are pregnant, or planning to become pregnant, to take extra care to protect themselves from the bites of the mosquitoes that transmits ZIKV ().…”

Section: Transmissionmentioning

confidence: 99%

Neurological manifestations of Zika virus infection

Blázquez

Saiz

2016

WJV

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Zika virus (ZIKV) is a flavivirus (Flaviviridae family) transmitted mainly by Aedes mosquitoes. The virus was restricted to the African continent until its spread to south-east Asia in the 1980’s, the Micronesia in 2007, the French Polynesia in 2013 and, more recently in the Americas in 2015, where, up to date, the World Health Organization (WHO) has estimated about 3-4 million total cases of ZIKV infection. During outbreaks in the French Polynesia and Brazil in 2013 and 2015, respectively, national health authorities reported potential neurological complications of ZIKV disease, chiefly an upsurge in Guillain-Barré syndrome, which coincided with ZIKV outbreaks. On the other hand, the emergence of ZIKV in Brazil has been associated with a striking increase in the number of reported cases of microcephaly in fetus and newborns, twenty times higher than in that reported in previous years. While investigations are currently assessing whether there is an actual association between neurological complications and ZIKV infections, the evidence was enough worrisome for WHO to declare a public health emergency of international concern. Here we present an updated review addressing what is currently known about the possible association between ZIKV infection and the development of severe neurological disorders.

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“…Dentro de los casos clínicos estudiados en el primer trimestre de embarazo, se demostró una serie de alteraciones consistentes en: lesión cerebral fetal grave asociada con transmisión vertical, restricción del crecimiento intrauterino acompañada de calcificaciones cerebrales, anormalidades en el flujo arterial cerebral o de ambas arterias umbilicales, oligohidramnios, anhidramnios e incluso muerte fetal. Aislándose este virus en líquido amniótico, membranas fetales, placenta y tejido cerebral fetal [11,12,28,[35][36][37].…”

Section: Complicacionesunclassified

Virus Zika en Centroamérica y sus complicaciones

et al. 2016

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El virus Zika (ZIKV) es un arbovirus, aislado por primera vez en Zika Uganda, reportándose el primer caso en humanos en 1954, desde entonces se han descrito casos en África, Asia, Oceanía y en América. Centroamérica ha sido afectada, por cambios climáticos, pobreza y mal saneamiento ambiental. Su transmisión es vectorial y puede tener transmisión perinatal, transfusiones sanguíneas o por semen infectado. Clínicamente se diferencian poco de Dengue y Chikungunya. Sus complicaciones son principalmente a nivel neurológico. Los Gobiernos de las regiones afectadas deberán tener políticas de control del vector, mejoría de viviendas y eliminación de basuras.

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Microcephaly and Zika virus

Cited by 51 publications

References 16 publications

Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses

Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses

Neurological manifestations of Zika virus infection

Virus Zika en Centroamérica y sus complicaciones

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