Can procalcitonin be a diagnostic marker for catheter-related blood stream infection in children?

Özsürekçi, Yasemin; Arıkan, Kamile; Bayhan, Cihangül; Karadağ‐Öncel, Eda; Aycan, Ahmet Emre; Gurbuz, Venhar; Hasçelik, Gülşen; Ceyhan, Mehmet

doi:10.1016/j.jped.2015.11.004

Cited by 21 publications

(9 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was shown that moderately elevated PCT (1–2.5 ng/mL) could be found in CAP with positive blood culture for Streptococcus pneumoniae mainly in bacterial superinfection after an initial viral episode, possibly reflecting transitory immune impairment ( 33 ). Further, PCT has been shown to strongly correlate with sepsis and septic shock in neutropenic ( 35 , 36 ) and immune-competent patients ( 32 , 37 ). PCT is particularly good in differentiating bacterial from viral meningitis in children ( 38 ) and seems to be useful to rule-in pyelonephritis, but studies on urinary tract infections display a high heterogeneity, which is why PCT cannot be recommended for antibiotic management of urinary tract infections at this point.…”

Section: Procalcitoninmentioning

confidence: 99%

Procalcitonin for Diagnostics and Treatment Decisions in Pediatric Lower Respiratory Tract Infections

et al. 2017

View full text Add to dashboard Cite

Mortality and morbidity remain high in pediatric lower respiratory tract infections (LRTIs) despite progress in research and implementation of global diagnostic and treatment strategies in the last decade. Still, 120 million annual episodes of pneumonia affect children younger than 5 years each year leading to 1.3 million fatalities with the major burden of disease carried by low- and middle-income countries (95%). The definition of pneumonia is still challenging. Traditional diagnostic measures (i.e., chest radiographs, C-reactive protein) are unable to distinguish viral and from bacterial etiology. As a result, common antibiotic overuse contributes to growing antibiotic resistance. We present an overview of current evidence from observational and randomized controlled trials on a procalcitonin (PCT)-based diagnosis of pediatric LRTIs and discuss the need for an adequate PCT threshold for antibiotic treatment decision-making.

show abstract

Section: Procalcitoninmentioning

confidence: 99%

Procalcitonin for Diagnostics and Treatment Decisions in Pediatric Lower Respiratory Tract Infections

et al. 2017

View full text Add to dashboard Cite

show abstract

“… 7 There are multiple studies about its superiority to C-reactive protein (CRP) as an infection biomarker. Its utility has been demonstrated in invasive infections, 8 nosocomial infection (NI), 9 – 12 and after cardiopulmonary bypass. 13 , 14 …”

Section: Introductionmentioning

confidence: 99%

Kinetics of Procalcitonin in Pediatric Patients on Extracorporeal Membrane Oxygenation

et al. 2018

View full text Add to dashboard Cite

Objectives:To assess the kinetics of procalcitonin (PCT) and C-reactive protein (CRP) in pediatric patients who required extracorporeal membrane oxygenation (ECMO) and to analyze its relationship with morbidity and mortality.Patients and methods:Prospective observational study including pediatric patients who required ECMO. Both PCT and CRP were sequentially drawn before ECMO (P0) and until 72 hours after ECMO.Results:A total of 40 patients were recruited. Two cohorts were established based on the value of the P0 PCT (>10 ng/mL). Comparing the kinetics of PCT and CRP in these cohorts, the described curves were the expected for each clinical situation. The cutoff for P0 PCT to predict multiple organ dysfunction syndrome was 2.55 ng/mL (sensibility 83%, specificity 100%). Both PCT and CRP did not predict risk of neurologic sequelae or mortality in any group.Conclusions:Procalcitonin does not seem to be modified by ECMO and could be a good biomarker of evolution.

show abstract

“…High PCT should serve to warn about nosocomial infection in those patients without other causes of higher PCT such as cardiopulmonary arrest and some kinds of surgeries, especially with PCT levels up to 2 ng/mL. 66 It is also useful for diagnosis of catheter-related-infection in those patients in whom other infections are also under study 75 (Table 4).…”

Section: • • Nosocomial Infectionsmentioning

confidence: 99%

Is Procalcitonin Useful in Pediatric Critical Care Patients?

2018

View full text Add to dashboard Cite

show abstract

Can procalcitonin be a diagnostic marker for catheter-related blood stream infection in children?

Abstract: The authors suggest that PCT could be a helpful rapid diagnostic marker in children with suspected CRBSIs.

Cited by 21 publications

References 24 publications

Procalcitonin for Diagnostics and Treatment Decisions in Pediatric Lower Respiratory Tract Infections

Procalcitonin for Diagnostics and Treatment Decisions in Pediatric Lower Respiratory Tract Infections

Kinetics of Procalcitonin in Pediatric Patients on Extracorporeal Membrane Oxygenation

Is Procalcitonin Useful in Pediatric Critical Care Patients?

Contact Info

Product

Resources

About