Comparison of two dose regimens of ibuprofen for the closure of patent ductus arteriosus in preterm newborns

Dornelles, Laura Vargas; Corso, Andrea; Silveira, Rita de Cássia dos Santos; Procianoy, Renato S.

doi:10.1016/j.jped.2015.09.009

Cited by 11 publications

(7 citation statements)

References 22 publications

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“…Thirteen studies were excluded because they were not observational studies while two were excluded as they did not report OR or original data for OR calculation. Five records did not include the outcome of the risk of AKI [19][20][21][22][23] while three studies included population that did not meet the inclusion criteria (less than 50 patients or inaccurate age classification). [24][25][26] Hence these eight studies were excluded from this meta-analysis as well.…”

Section: Resultsmentioning

confidence: 99%

Nonsteroidal anti‐inflammatory drugs associated acute kidney injury in hospitalized children: A systematic review and meta‐analysis

Gong

et al. 2021

Pharmacoepidemiology and Drug

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Introduction: Nonsteroidal anti-inflammatory drugs (NSAIDs) are regarded as nephrotoxins. Children commonly use NSAIDs and are susceptible to nephropathy, but the relationship between acute kidney injury (AKI) and use of NSAIDs is not well examined yet.Objective: To evaluate the relationship between AKI and use of NSAIDs in hospitalized pediatric patients who are susceptible to nephropathy. Methods:We conducted this systematic review and meta-analysis of observational studies by searching PubMed, Embase, and Cochrane Database for articles published up to June 1, 2020. Reports included involved children (age < 18 years) who used NSAIDs for various reasons and were admitted in the hospital. The main outcome measure was whether AKI occurred, and pooled odds ratio (OR) and 95% confidence intervals (CI) were calculated using generic inverse variance methods.Results: Seven studies reporting risk of AKI in the hospitalized pediatric patients receiving NSAIDs were included applying a random-effects model. In the hospitalized pediatric population, the pooled OR of AKI for present NSAID exposure was 1.55 (95%CI 1.26-1.92).Conclusions: NSAID exposure was associated with an approximate 1.6-fold rise in the odds of developing AKI in hospitalized pediatric patients. Avoidance, cautious use of NSAIDs and further evidence are needed. This study was registered with PROSPERO (identifier: CRD42021219779).

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Section: Resultsmentioning

confidence: 99%

Nonsteroidal anti‐inflammatory drugs associated acute kidney injury in hospitalized children: A systematic review and meta‐analysis

Gong

et al. 2021

Pharmacoepidemiology and Drug

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“…To evaluate the clinical PDA score including eight parameters (PP, HR, A/MV, FP, SM, HM, AC, PD) we compared its sensitivity and specificity to predict the presence of an hsPDA as diagnosed by echocardiography. Using logistical regression analysis and ROC ( 29 ) curves, we compared the strength of combining particular items of the score and determined its sensitivity and specificity. More precise, for each day (2–4) we performed logistical regression analyses of all eight clinical parameters (from the initial score) and tested for statistical significance.…”

Section: Resultsmentioning

confidence: 99%

“… (A,B) Sensitivity and specificity of the clinical PDA score. Using multivariate logistic regression analysis (daily) and receiver operating characteristic (ROC) ( 29 ) curves, we compared the power of combinations of particular features and determined the sensitivity and specificity (dependent on the determined cutoff-level). The theoretical optimal cutoff-level was 1.5 points.…”

Section: Resultsmentioning

confidence: 99%

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Development of a Diagnostic Clinical Score for Hemodynamically Significant Patent Ductus Arteriosus

et al. 2017

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There is no consensus about the hemodynamic significance and, therefore, the need to treat a persistent ductus arteriosus in preterm newborns. Since the diagnosis of a hemodynamically significant persistent ductus arteriosus (hsPDA) is made by a summary of non-uniform echo-criteria in combination with the clinical deterioration of the preterm neonate, standardized clinical and ultrasound scoring systems are needed. The objective of this study was the development of a clinical score for the detection and follow-up of hsPDA. In this observational cohort study of 154 preterm neonates (mean gestational age 28.1 weeks), clinical signs for the development of hsPDA were recorded in a standardized score and compared to echocardiography. Analyzing the significance of single score parameters compared to the diagnosis by echocardiography, we developed a short clinical score (calculated sensitivity 84% and specificity 80%). In conclusion, this clinical diagnostic PDA score is non-invasive and quickly to implement. The continuous assessment of defined clinical parameters allows for a more precise diagnosis of hemodynamic significance of PDA and, therefore, should help to detect preterm neonates needing PDA-treatment. The score, therefore, allows a more targeted use of echocardiography in these very fragile preterm neonates.

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“…In regard to the multiple treatment comparisons, only 1 network meta-analysis compared intravenous indomethacin, intravenous ibuprofen, and placebo for hemodynamically significant PDA but did not include evidence for acetaminophen. Oral acetaminophen has recently emerged as a new treatment option as well as higher doses of oral ibuprofen . Use of a network meta-analysis framework has enabled comparisons among currently used PDA treatment modalities, which has increased the statistical power by taking advantage of direct and indirect treatment comparisons.…”

Section: Discussionmentioning

confidence: 99%

Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants

Mitra

Flórez

Tamayo

et al. 2018

JAMA

243

222

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Comparison of two dose regimens of ibuprofen for the closure of patent ductus arteriosus in preterm newborns

Abstract: There was no difference in closure of the ductus arteriosus or occurrence of adverse effects between the two dose regimens.

Cited by 11 publications

References 22 publications

Nonsteroidal anti‐inflammatory drugs associated acute kidney injury in hospitalized children: A systematic review and meta‐analysis

Nonsteroidal anti‐inflammatory drugs associated acute kidney injury in hospitalized children: A systematic review and meta‐analysis

Development of a Diagnostic Clinical Score for Hemodynamically Significant Patent Ductus Arteriosus

Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants

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