Circulating endothelial progenitor cells in obese children and adolescents

Pires, António; Martins, Paula; Paiva, Artur; Pereira, Ana Margarida; Marques, Margarida; Castela, Eduardo; Sena, Cristina M.; Seiça, Raquel

doi:10.1016/j.jped.2015.01.011

Cited by 10 publications

(6 citation statements)

References 29 publications

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“…22 Similarly, endothelial progenitor cells, which are bone marrow-derived progenitor cells involved in neovasculogenesis and maintenance of vascular integrity, 43 are increased in obese youth. 44,45 While this suggests early endothelial damage, it also shows that the adaptive response to the haemodynamic consequences of obesity and the endothelial reparative mechanisms are still well intact among obese children, suggesting that early intervention to revert obesity during childhood may revert also their cardiovascular risk. factors that should be considered.…”

Section: Vascular Changesmentioning

confidence: 99%

Risk factors and predictive biomarkers of early cardiovascular disease in obese youth

Maddaloni

Buzzetti

2019

Diabetes Metabolism Res

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Obesity in childhood and adolescence continues to be a major health issue due to significant health implications and to the economic burden that arise from treating this disease and its complications. Current data show that childhood obesity is no longer just a concern for developed countries, but more significantly affecting developing countries. In adult population, cardiovascular disease is the main cause of mortality and morbidity among obese patients. It is therefore believed that risk factors found in adult patients could also be observed in obese youth. These risk factors will then persist and become progressively worse if obese youth remain obese as they reach adulthood. However, risk reduction is achievable through various prevention and management strategies of obesity and obese children who become nonobese in adulthood have a significant reduction in their risk of developing cardiovascular disease.New biomarkers to improve risk assessment in obese youth are an open research field, which will eventually lead to a more targeted approach in prevention and treatment. Nevertheless, there is still a need for continuous research in understanding the roles of these biomarkers and their potential in risk prediction. Cardiovascular risk modification of childhood obesity depends on a more concerted effort among the various parties involved and particularly a global collaboration to stop the rising prevalence of the epidemic in developing countries.

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Section: Vascular Changesmentioning

confidence: 99%

Risk factors and predictive biomarkers of early cardiovascular disease in obese youth

Maddaloni

Buzzetti

2019

Diabetes Metabolism Res

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“…Similarly, endothelial dysfunction has been demonstrated in obese children [ 17 , 18 ]. In these children, compensatory elevation of circulating endothelial progenitor cell counts suggest that in early life, obesity-mediated endothelial dysfunction may still be reversible [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of retinal vascular geometry in obese and non-obese children

et al. 2018

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PurposeChildhood obesity is associated with adult cardiometabolic disease. We postulate that the underlying microvascular dysfunction begins in childhood. We thus aimed to compare retinal vascular parameters between obese and non-obese children.MethodsThis was a cross-sectional study involving 166 children aged 6 to 12 years old in Malaysia. Ocular examination, biometry, retinal photography, blood pressure and body mass index measurement were performed. Participants were divided into two groups; obese and non-obese. Retinal vascular parameters were measured using validated software.ResultsMean age was 9.58 years. Approximately 51.2% were obese. Obese children had significantly narrower retinal arteriolar caliber (F(1,159) = 6.862, p = 0.010), lower arteriovenous ratio (F(1,159) = 17.412, p < 0.001), higher venular fractal dimension (F(1,159) = 4.313, p = 0.039) and higher venular curvature tortuosity (F(1,158) = 5.166, p = 0.024) than non-obese children, after adjustment for age, gender, blood pressure and axial length.ConclusionsObese children have abnormal retinal vascular geometry. These findings suggest that childhood obesity is characterized by early microvascular abnormalities that precede development of overt disease. Further research is warranted to determine if these parameters represent viable biomarkers for risk stratification in obesity.

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“…It has been reported that most metabolically healthy obese individuals do not exhibit a high risk of diabetes development where IR is present (40). In addition, the numbers of angiogenic progenitor mononuclear cells appear to be increased in the MetS patient population (41). In contrast, MetS individuals have shown decreased levels of progenitor mononuclear cells with angiogenic immune phenotypes (42), which independently predict CV and atherosclerotic disease progression (43,44).…”

Section: Discussionmentioning

confidence: 99%

Links between concentrations of serum 25-hydroxyvitamin D3 and the numbers of circulating progenitor mononuclear cells in patients with metabolic syndrome

et al. 2017

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Circulating endothelial progenitor cells in obese children and adolescents

Abstract: Circulating endothelial progenitor cell count is elevated in obese children and adolescents with evidence of endothelial activation, suggesting that, during infancy, endothelial repairing mechanisms are present in the context of endothelial activation.

Cited by 10 publications

References 29 publications

Risk factors and predictive biomarkers of early cardiovascular disease in obese youth

Risk factors and predictive biomarkers of early cardiovascular disease in obese youth

Comparison of retinal vascular geometry in obese and non-obese children

Links between concentrations of serum 25-hydroxyvitamin D3 and the numbers of circulating progenitor mononuclear cells in patients with metabolic syndrome

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