Protective effects of human milk antimicrobial peptides against bacterial infection

Håkansson, Anders P.

doi:10.1016/j.jped.2014.10.001

Cited by 9 publications

(7 citation statements)

References 21 publications

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“…En "leche materna: efecto protector contra las alergias y factor estimulante del crecimiento", las publicaciones listadas corroboran los numerosos beneficios de la lactancia materna en la prevención de las enfermedades, en las diversas etapas de la vida del niño, especialmente aquellas que se producen de forma concomitante con síntomas alérgicos (16,17) .…”

Section: Discussionunclassified

The early food introduction and the risk of allergies: A review of the literature

Silva¹,

Monteiro²,

Tavares³

et al. 2019

Enf Global

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lactancia materna se considera un recurso fundamental para promover la salud nutricional del niño, con repercusiones a lo largo de la vida. La introducción de alimentos precozmente en la dieta infantil es un factor de riesgo para el desarrollo de enfermedades crónicas, como la alergia a la proteína de la leche de vaca. Esta investigación tiene como objetivo: analizar las publicaciones sobre la baja prevalencia de la lactancia materna, la introducción de la leche precoz en la dieta del bebé y el desarrollo de alergias alimentarias. Se trata de una revisión integrativa de la literatura, la búsqueda fue realizada en las bases de datos Lilacs, Pubmed, Science Direct, Capes y BVS, con descriptores previamente enumerados, entre los años 2008 a 2017. Se utilizaron los criterios de inclusión: artículos en línea disponible en su totalidad y publicados en portugués, inglés y español, obteniendo una muestra de 11 artículos. Se hizo un examen crítico de cada investigación, separándolas en cuatro categorías diferentes de forma que hiciera posible el análisis y respuesta a la pregunta orientadora de este estudio. Ante lo obtenido, se identificó la necesidad de más estudios sobre el tema, a fin de orientar y / o actualizar a los profesionales de salud en el mantenimiento de la lactancia materna en lactantes con restricciones nutricionales.Palabras clave: lactancia materna; nutrición del lactante; hipersensibilidade a la leche. RESUMO:O aleitamento materno é considerado um recurso fundamental para promoção da saúde nutricional da criança, com repercussões ao longo da vida. A introdução de alimentos precocemente à dieta infantil é fator de risco para o desenvolvimento de doenças crônicas, como a alergia à proteína do leite de vaca. Enfermería GlobalNº 54 Abril 2019Página 471 Esta pesquisa tem como objetivo: analisar as publicações acerca da baixa prevalência do aleitamento materno, a introdução do leite precoce na dieta do bebê e o desenvolvimento de alergias alimentares. Trata-se de uma revisão integrativa da literatura, a busca foi realizada nas bases de dados Lilacs, Pubmed, Science Direct, Capes e BVS, com descritores previamente elencados, entre os anos de 2008 a 2017. Foram utilizados os critérios de inclusão: artigos online, disponíveis na íntegra e publicada nos idiomas português, inglês e espanhol, obtendo uma amostra de 11 artigos. Foi feito um exame crítico de cada pesquisa, separando-as em quatro categorias diferentes de forma que tornasse possível a análise e resposta a pergunta norteadora deste estudo. Diante do obtido, identificou-se a necessidade de mais estudos sobre o tema, a fim de nortear e/ ou atualizar os profissionais de saúde na manutenção da amamentação em lactentes com restrições nutricionais.Palavras-chave: aleitamento materno; nutrição do lactente; hipersensibilidade a leite. ABSTRACT:Breastfeeding is considered a vital resource for promoting the child's nutritional health, with repercussions throughout life. The early food introduction to the infant diet is a risk factor for the development of chronic...

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Section: Discussionunclassified

The early food introduction and the risk of allergies: A review of the literature

Silva¹,

Monteiro²,

Tavares³

et al. 2019

Enf Global

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“…For the past 30 years, scientists observed that high levels of secretory immunoglobulin A and oligosaccharides could prevent adherence of harmful microbes to the gut mucosa (Gibbs et al 1977 ; Prentice et al 1985 ). Currently, increasing numbers of studies seek to improve understanding of the importance of breast milk, especially antimicrobial components such as antimicrobial peptides (AMPs), against infections (Hakansson 2015 ; Lepage and Van de Perre 2012 ; Ovali et al 2006 ). Researchers hope to improve the biological activity of formula milk.…”

Section: Discussionmentioning

confidence: 99%

“…Many researchers discovered that a multitude of endogenous peptides had antimicrobial activities. The mechanism of antimicrobial activity against bacteria was mostly via permeabilization of the membrane and DNA binding, which could explain the antimicrobial activity of human milk (Hakansson 2015 ). These peptides could be developed as potential ingredients of health-promoting foods supplied into formula, and even therapeutics (Mohanty et al 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Investigation into the antimicrobial action and mechanism of a novel endogenous peptide β-casein 197 from human milk

Chen

et al. 2017

AMB Expr

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A novel endogenous peptide cleaved from 197–213 AA of β-casein, named β-casein 197, was identified by tandem mass spectrometry. β-casein 197 constituted a significant proportion of the peptide content in preterm milk. This study investigated the antibacterial effects and mechanisms against common pathogenic bacteria. Six bacterial strains were selected for this study: Escherichia coli, Staphylococcus aureus, Yersinia enterocolitica, Listeria monocytogenes, Klebsiella pneumonia and Bacillus subtilis. After synthesis, serial twofold dilutions of β-casein 197 were added to select for sensitive bacteria. The disk diffusion method and analysis of bacterial staining were used to identify antibacterial effect, while DNA-binding, scanning electron microscopy and transmission electron microscopy were used to explore antimicrobial mechanisms. Disk diffusion showed that E. coli, S. aureus and Y. enterocolitica were sensitive to the β-casein 197. In addition, live/dead fluorescent staining also confirmed antibacterial effects. Scanning electron and transmission electron microscopy revealed affected extracellular and intracellular structure for three species of bacteria, while a DNA-binding assay showed that the antimicrobial activity did not occur through DNA binding. This study suggests that β-casein 197 has antimicrobial activity against common pathogenic bacteria in newborns with infection. The peptide induced membrane permeabilization but did not bind to genomic DNA. Based on our findings, β-casein 197 has potential clinical value for preventing infections of premature infants.

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“…They are involved in (a) direct outright killing the microbes, (b) neutralizing the bacteria and viruses and making them ineffective or (c) indirectly by blocking the initial attachment/adherence of the bacteria to mucosal surfaces. Besides this, these molecules also modulate the immune system by activating immune cells against infectious agents and strengthening the innate system against life-threatening infections and those targeting the mucosal lining (gastrointestinal infections, skin infections, respiratory tract infections) [12][13][14]. The combination of immunomodulation and antimicrobial factors help the child to avoid the development of various childhood infections and inflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

Prophylactic and Therapeutic Role of Human Breast Milk Proteins and Bioactive Peptides against Neonatal Bacterial Infections

Kaur¹,

Panaich²,

Virk³

et al. 2020

Infant Feeding - Breast Versus Formula

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Breast milk represents nature’s best mechanism to provide complete nourishment and protection to the newborn. Human breast milk acts as a store house of an array of bioactive factors, which includes antimicrobial proteins and antimicrobial peptides that confer early protection while lowering the incidence of developing various infections and exhibiting immune modulation property to activate the immune cells to fight against the invading pathogens. Among the bioactive peptides, endogenous peptides present in breast milk have opened a new window of research on studying their unique mechanisms of action. This will help in incorporating these peptides in formula milk for meeting special needs where breastfeeding is not possible. The present chapter aims to give a deep insight into the various antimicrobial peptides and the newly reported endogenous peptides in human breast milk with emphasis on their levels and activity in preterm milk as data related to this is lacking and preterm newborns are highly vulnerable to acquire infections. Further, the chapter focuses on highlighting the antibacterial mechanisms adopted by the bioactive peptides for protection against the neonatal bacterial pathogens with special emphasis on the infections caused by resistant bacterial strains in hospital settings (neonatal wards) and their future implications.

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Protective effects of human milk antimicrobial peptides against bacterial infection

Cited by 9 publications

References 21 publications

The early food introduction and the risk of allergies: A review of the literature

The early food introduction and the risk of allergies: A review of the literature

Investigation into the antimicrobial action and mechanism of a novel endogenous peptide β-casein 197 from human milk

Prophylactic and Therapeutic Role of Human Breast Milk Proteins and Bioactive Peptides against Neonatal Bacterial Infections

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