Peri-intraventricular hemorrhage and oxidative and inflammatory stress markers in very-low birth weight newborns

Caldas, Jamil Pedro de Siqueira; Braghini, Carolina Ayumi; Mazzola, Taís Nitsch; Vilela, M. M. S.; Marba, Sérgio Tadeu Martins

doi:10.1016/j.jped.2014.09.008

Cited by 10 publications

(9 citation statements)

References 36 publications

(25 reference statements)

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“…These include glutathione [ 53 , 109 ], antioxidant vitamins [ 106 , 110 ], uric acid [ 111 ], ubiquinone-reducing substances [ 54 , 112 ], metallothionein [ 113 ], and thioredoxin system [ 114 , 115 ]. However, methods for the detection of oxidative stress related nonenzymatic antioxidants in the peripheral blood are few; one study on the level of glutathione (GSH) in umbilical cord blood after neonatal periventricular hemorrhage found that cord blood GSH level was not related to intraventricular hemorrhage in low-birthweight neonates [ 116 ]. Uric acid is an antioxidant molecule of the body, but studies have found that although serum uric acid levels are related to ischemic stroke, they have no significant correlation with ICH [ 111 ].…”

Section: Detection Of the Level Of Oxidative Stressmentioning

confidence: 99%

Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy

Duan

Wen

Shen

et al. 2016

Oxidative Medicine and Cellular Longevity

220

169

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Hemorrhagic stroke is a common and severe neurological disorder and is associated with high rates of mortality and morbidity, especially for intracerebral hemorrhage (ICH). Increasing evidence demonstrates that oxidative stress responses participate in the pathophysiological processes of secondary brain injury (SBI) following ICH. The mechanisms involved in interoperable systems include endoplasmic reticulum (ER) stress, neuronal apoptosis and necrosis, inflammation, and autophagy. In this review, we summarized some promising advances in the field of oxidative stress and ICH, including contained animal and human investigations. We also discussed the role of oxidative stress, systemic oxidative stress responses, and some research of potential therapeutic options aimed at reducing oxidative stress to protect the neuronal function after ICH, focusing on the challenges of translation between preclinical and clinical studies, and potential post-ICH antioxidative therapeutic approaches.

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Section: Detection Of the Level Of Oxidative Stressmentioning

confidence: 99%

Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy

Duan

Wen

Shen

et al. 2016

Oxidative Medicine and Cellular Longevity

220

169

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“…In tissue injury process caused by oxidative stress, the lipid, protein and nucleic acid in cellular structure can react with oxygen free radicals, and these oxidized cell components will further cause cell dysfunction [21][22]. MDA, AOPP and 8-OHdG are the oxidation reaction products of lipid, protein and nucleic acid respectively, and can be used to evaluate the extent of the oxidative stress reaction after released into the blood circulation [23].…”

Section: Discussionmentioning

confidence: 99%

Curative effect of surgery combined with nerve growth factor preparation treatment of acute cerebral hemorrhage

Luo¹

2017

JAD

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“…Caldas et al [8] studied IL-6 levels in umbilical cord blood of 125 infants with very low birth weight, while the incidence rate of IVH was assessed through cranial ultrasound scans. No statistically significant associations were found between IL-6 levels and IVH either.…”

Section: Interleukin 6 (Il-6)mentioning

confidence: 99%

“…Association with increased risk of PHH, but not with WMI [27]. No association with increased risk of abnormal neurological outcome (including IVH) [34]IL-6Maternal vein blood serumNo association with increased risk of IVH [26]Umbilical cord bloodNo association with increased risk of IVH [7, 8, 10, 15, 30]Infant’s vein blood serumAssociation with increased risk of IVH, its severity, and higher neonatal morbidity [13]. Association with abnormalities in CUS only in infants born after or in week 28 of gestational age [34]Cerebrospinal fluidAssociation with increased risk of PHH, but not with WMI [27].…”

Section: Tumor Necrosis Factor (Tnf-alpha)mentioning

confidence: 99%

Role of selected cytokines in the etiopathogenesis of intraventricular hemorrhage in preterm newborns

et al. 2016

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Proinflammatory cytokines are essential mediators and indicators of an inflammatory process occurring in the body. Their physiological role is to stimulate the immune response, yet their excessive propagation and interaction with cells outside the immune system may be linked to the risk of organ damage. This is specifically important in the case of immature tissues of fetuses and prematurely born infants. Analysis of the concentrations of specific cytokines in different compartments makes it possible to assess the risk of premature birth, preterm rupture of the membranes, and to determine an existing intrauterine infection. The purpose of this paper is to summarize the existing research concerning the relationships between the concentrations of specific proinflammatory cytokines in different compartments (maternal blood serum, amniotic fluid, umbilical cord blood, arterial and venous blood, and cerebrospinal fluid of the newborn) and the risk of intraventricular hemorrhage (IVH) and the degree of its severity. The paper takes also into account the assessment of the usefulness of cytokines as biomarkers for IVH and its complications (posthemorrhagic hydrocephalus, white matter injury).Keywords Intraventricular hemorrhage . Proinflammatory cytokines . Premature birth Dynamic development of perinatal medicine and neonatology has contributed to increased survival rates among prematurely born infants, leading at the same time to a relative increase in the number of multi-organ complications occurring in these babies. Intracranial, mainly intraventricular hemorrhages (IVHs), resulting from the immaturity of brain structures, represent one of the most common pathologies in premature infants. The incidence of this pathology is inversely proportional to gestational age. There are four degrees of IVH severity, graded I-IV [21]. Bleeding graded I and II is often self-limiting. Higher grade hemorrhages result in higher risk of neurodevelopmental delay; they are also the main cause of cerebral palsy and increased perinatal mortality rates in this group of infants [7,20]. It is estimated that IVH occurs in as much as 20% of infants born before 32nd week of gestation [4].The etiopathogenesis of IVH is complex. Besides gestational age (below 32 weeks) and body weight at birth (less than 1500 g), there are also other IVH risk factors identified, including absence of prenatal steroid therapy in women at risk of premature delivery, early clamping of the umbilical cord (less than 30 s after birth), symptoms of intrauterine infection in the mother and the newborn, and labor and delivery complicated by bleeding or perinatal hypoxia. The group of infants with an elevated IVH risk includes also newborns with intrauterine growth retardation or those who in the first days of their life were treated with crystalloids (bolus 10-15 ml/kg) and/or catecholamins for hypotension and NaHCO 3 for acidosis. IVH risk group includes also newborns with blood clotting disorders, thrombocytopenia, hypoglycemia, pneumothorax, lung bleeding, and...

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Peri-intraventricular hemorrhage and oxidative and inflammatory stress markers in very-low birth weight newborns

Abstract: ROI, GSH, and IL-6 levels were not associated with the occurrence of PIVH in very-low birth weight infants.

Cited by 10 publications

References 36 publications

Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy

Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy

Curative effect of surgery combined with nerve growth factor preparation treatment of acute cerebral hemorrhage

Role of selected cytokines in the etiopathogenesis of intraventricular hemorrhage in preterm newborns

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