Prevalence of myocarditis in pediatric intensive care unit cases presenting with other system involvement

Rady, Hanaa Ibrahim; Zekri, Hanan

doi:10.1016/j.jped.2014.05.011

Cited by 15 publications

(11 citation statements)

References 28 publications

(25 reference statements)

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“… 1 – 3 FM had a very high mortality ranging from 25% to 75% without immediate mechanical circulatory support. 4 In cases of cardiogenic shock or cardiac arrest refractory to usual resuscitative therapies such as vasopressors or intra-aortic balloon pumps (IABPs), left ventricular assist devices have been used as a supportive therapy in FM but are often bulky and invasive. 5 – 7 In contrast, a more readily accessible intervention, extracorporeal membrane oxygenation (ECMO), has been shown to be an effective life-saving strategy in adult patients with FM.…”

Section: Introductionmentioning

confidence: 99%

ECMO as an effective rescue therapeutic for fulminant myocarditis complicated with refractory cardiac arrest

Yang

Chen

et al. 2017

TCRM

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Fulminant myocarditis (FM) is a life-threatening disease in children. With a rapid, progressive course of deterioration, it causes refractory cardiorespiratory failure even with optimal clinical intervention. We present the case of a 9-year-old girl with FM complicated by cardiogenic shock, malignant arrhythmia, and refractory cardiac arrest. She received effective cardiopulmonary resuscitation, therapeutic hypothermia, and other supportive treatments. However, the patient rapidly worsened into pulseless ventricular tachycardia and refractory cardiac arrest. Therefore, we performed extracorporeal membrane oxygenation (ECMO) to establish spontaneous circulation after the failure of standard resuscitation measures. The girl recovered with intact cardiac and neurocognitive functions after continued ECMO treatment for 221 hours. Therefore, ECMO is an effective rescue therapeutics for FM, especially when complicated with refractory cardiac arrest.

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Section: Introductionmentioning

confidence: 99%

ECMO as an effective rescue therapeutic for fulminant myocarditis complicated with refractory cardiac arrest

Yang

Chen

et al. 2017

TCRM

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“…In a similar study done in Cairo University, prevalence was 25.3% [18]. Mean age of presentation of myocarditis patients was 6.1 ± 3.4 years.…”

Section: Discussionmentioning

confidence: 57%

Myocarditis in children presenting with acute febrile illness

et al. 2016

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Objective: Myocarditis is the inflammatory disease of myocardium. The objective of this study was to determine the prevalence of myocarditis in children presenting with acute febrile illness, the frequency of various presenting symptoms, and the accuracy of different investigations in the diagnosis and to know the outcome and etiological agents causing myocarditis. Methods: This prospective observational study was done in 125 children aged 1-15 years presenting with acute febrile illness. Patients were diagnosed as suspicious case of myocarditis on the basis of expanded criteria of myocarditis. Suspicious myocarditis patients were compared with those who did not have myocarditis in terms of clinical feature, investigation and outcome and were also investigated for etiology. Results: 43 patients were diagnosed as suspected myocarditis according to expanded criteria. Mean age was 6.1 ± 3.4 years and male: female ratio was 1.2:1. A significant association was present between patients with myocarditis and following signs and symptoms: chest pain, palpitation, dyspnea, swelling of body, pedal edema, abdominal tenderness, hepatomegaly and crepitations. Following investigations were significantly abnormal in patients with myocarditis: hypokalaemea, billirubin >1.2 mg/dl, mean AST and ALT, CPK-MB and BNP. Conclusions: Children with myocarditis present with symptoms that can be mistaken for other system involvement. When clinical suspicion of myocarditis exists, chest-X ray, cardiac enzymes and echocardiography are sufficient as screening tests. Many common causes of acute onset fever can cause myocaditis. Therefore its diagnosis is necessary for prompt treatment.

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“…Myocarditis was the most common diagnosis in this group; 25/172 patients (14.5%). Patients diagnosed with myocarditis were identified based on the combination of elevated specific cardiac biomarkers in blood, such as Troponin and CK-MB, sinus tachycardia disproportionate to the age of the patient during an electrocardiogram (ECG), and echocardiographic findings of fractional shortening and dilated left ventricle or both ventricles 18 . Histopathological confirmation was also performed in few cases of myocarditis.…”

Section: Discussionmentioning

confidence: 99%

Clinical and biochemical spectrum of metabolic cardiomyopathy in Egyptian children

Seliem¹,

Mehaney²,

Selim³

et al. 2022

Afr H. Sci.

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Background: Inborn errors of metabolism (IEMs) commonly present with pediatric cardiomyopathy. Identification of the underlying cause is necessary as it may lead to improved outcomes. Objectives: We aimed to investigate the diagnostic rate, the clinical, and biochemical spectra of IEMs among Egyptian pediatric patients presenting with cardiomyopathy, and their outcome measures. Methods: We retrospectively analyzed the clinical, biochemical, and radiological data of 1512 children diagnosed with cardiomyopathy at Cairo University Children’s Hospital over a 5-year duration. Results: Two hundred twenty-nine children were clinically suspected as IEMs and underwent metabolic workup. Nineteen different IEMs were confirmed in 57 (24.4%) of the suspected children. Their median age at presentation was 2.6 years and the majority had extra-cardiac manifestations. Hypertrophic cardiomyopathy represented 43/57 (75.4%) of confirmed cases, while dilated cardiomyopathy represented 13/57 (22.8%), and one patient presented with a mixed phenotype. Twenty- six patients (45.6%) survived, while 31 patients (54%) either died or were lost to follow up and assumed deceased. Conclusions: We developed for the first time a database and a diagnostic scheme for metabolic cardiomyopathies in Egyptian children. With the recent introduction of enzyme replacement therapy, many metabolic disorders became treatable, thus establishing an early and accurate diagnosis is extremely important. Keywords: Cardiomyopathy; inborn errors of metabolism; pediatric.

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Prevalence of myocarditis in pediatric intensive care unit cases presenting with other system involvement

Cited by 15 publications

References 28 publications

ECMO as an effective rescue therapeutic for fulminant myocarditis complicated with refractory cardiac arrest

ECMO as an effective rescue therapeutic for fulminant myocarditis complicated with refractory cardiac arrest

Myocarditis in children presenting with acute febrile illness

Clinical and biochemical spectrum of metabolic cardiomyopathy in Egyptian children

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