Biventricular diastolic function assessed by Doppler echocardiogram in children vertically infected with human immunodeficiency virus

Silva, Mauricio L.; Nassar, Sílvia Modesto; Silva, André P.; Ponce, Leandro; Pires, Maria Marlene de Souza

doi:10.1016/j.jped.2014.01.004

Cited by 3 publications

(5 citation statements)

References 25 publications

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“…This conflicting finding may be due to the timing of the study. In the pre HAART era it was so [ 29 ] but now it is showing a different pattern [ 28 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…This may lead to variation in result. Drug treatment with HAART is reported to have varying effect, ranging from cardio protection to cardiotoxicity [ 29 , 31 ]. Some drugs used in HAART such as zidovudine (AZT) and abacavir (ABC) have been noted to have cardiotoxicity effect.…”

Section: Discussionmentioning

confidence: 99%

“…This was also observed in this index study, as cases on this regimen showed higher prevalence of LVH as shown in Table 1 . The links between HAART and LVH have been reported [ 29 , 30 ]. The authors reported LV dysfunction in HIV-infected patients on HAART, especially AZT [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…The links between HAART and LVH have been reported [ 29 , 30 ]. The authors reported LV dysfunction in HIV-infected patients on HAART, especially AZT [ 29 , 30 ]. Other workers [ 8 , 31 ], had reported that AZT has no effect on cardiac muscles.…”

Section: Discussionmentioning

confidence: 99%

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Left ventricular hypertrophy in African children infected with HIV/AIDS: a case control study

Arodiwe¹,

Eke²,

Arodiwe³

2023

Pan Afr Med J

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Introduction left ventricular hypertrophy (LVH) measured by echocardiography seen in human immunodeficiency virus/acquired immunodeficiency disease (HIV/AIDS) affects the morbidity and mortality. The hemodynamic and metabolic changes in (HIV/AIDS) affect the heart adversely causing hypertrophic remodeling with left ventricular hypertrophy. The aim of this study was to determine the prevalence and risk factors associated with LVH in African children with HIV/AIDS. Methods an analytical case-control study was conducted using echocardiography to assess cardiac function. Descriptive statistics was used to determine percentages and univariate analysis to find association between dependent variable and independent variables. Independent variables that had an association in a univariate were included in the multivariate model to determine strength of association. Results the mean age of the study population was 7.8 ± 2.07 years for controls and 8.3 ± 3.04 years for cases respectively. They were made up of 51.2% (n= 86) males and 48.8% (n = 82) females (M: F=1.05: 1). We studied eighty-four (n= 84) cases, and LVH was seen in 67.7% (n= 56) of the patients. Mean left ventricular mass index (g/m 2 ) was significantly higher in the cases (90.37± 35.50) than controls (89.37 ± 14.25, p= 0.04.) Relative wall thickness (mm) was within normal in the control, 0.35 ± 0.06 and high in the cases, 0.67 ± 0.17, p= 0.01. Eccentric hypertrophy was the most common type seen in 36.9% (n= 31) of the patients. Multiple linear regression analysis, revealed that the presence of LVH was associated with 0.212 (95% CI: 0.001 - 0.014; p= 0.001) lower Body mass index (BMI) for age and 0.396 (95% CI; 0.002 - 0.066; p= 0.03) lower CD4+ cell count as predictors of LVH. Conclusion the prevalence of LVH was high. Lower body mass index (BMI) and CD4+cells count predicted LVH. This supports the recommendation by the National Heart, Lung and Blood Institute (NHLBI) working group on research priorities for cardiovascular complications in HIV/AIDS, for baseline and periodic echocardiography in the management of children with HIV/AIDS.

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“…This conflicting finding may be due to the timing of the study. In the pre HAART era it was so [ 29 ] but now it is showing a different pattern [ 28 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Left ventricular hypertrophy in African children infected with HIV/AIDS: a case control study

Arodiwe¹,

Eke²,

Arodiwe³

2023

Pan Afr Med J

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“…Left or right ventricular diastolic dysfunction, predominantly of restrictive pattern (high E/A ratio), has been found in around 40% and 25% of clinically stable HIV infected children, respectively. 29 Its relation with HIV treatment status has not been clearly demonstrated, but ART may play a role as HIV-exposed but uninfected infants who have been exposed to prophylactic ART have lower early diastolic annular velocity than controls. 30 …”

Section: Ventricular Functionmentioning

confidence: 99%

Cardiovascular manifestations of HIV infection in children

Idris

Grobbee

Burgner

et al. 2014

Eur J Prev Cardiolog

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HIV infection in children may greatly impact the cardiovascular system, including effects on the heart, which tend to manifest early in childhood, and on the vasculature. The underlying mechanisms, essential for targeted prevention, are poorly understood. Current evidence largely stems from research in adults. However, as modes of infection, immune maturity, growth and development, and treatment are markedly different in children, specific pediatric research, accounting for the complex interplay of normal growth and development, HIV infection and treatment, is clearly warranted.

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Left Ventricular Function, Epicardial Adipose Tissue, and Carotid Intima-Media Thickness in Children and Adolescents With Vertical HIV Infection

Marsico

Vecchio

Paolillo

et al. 2019

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Background: Life expectancy of HIV patients has increased considerably as a result of antiretroviral therapy (ART), and cardiovascular (CV) disease has emerged as an important late concern. People with HIV infection could have an impaired systolic function; however data on diastolic function and markers of CV risk, such as epicardial adipose tissue (EAT) and intima-media thickness (IMT), are lacking. Aim of this study is to evaluate left ventricular function, EAT, and IMT in children and adolescents with vertically acquired HIV infection. Methods: We enrolled 29 subjects on ART (13, 45% men; median age of 13.0, and interquartile range 9–18), and 29 age-matched controls. All patients and controls underwent echocardiographic evaluation, with study of the systolic and diastolic function and measurement of the EAT, and a carotid ultrasound study for IMT measurement. Results: Comparing HIV-infected patients to healthy controls, we found a statistically significant increase of EAT and IMT (mean ± SD) (EAT: 3.16 ± 1.05 vs 1.24 ± 0.61 mm; P < 0.0001. IMT: 0.77 ± 0.15 vs 0.51 ± 0.11 mm; P < 0.0001), and a significant reduction of ejection fraction, evaluated with the biplane Simpson method (mean ± SD) (58.5% ± 6.66% vs 66% ± 4.24%; P = 0.029). These results are not related with age, gender, degree of lipodystrophy, dyslipidemia, hyperinsulinism, and ART duration or the use of single antiretroviral classes. Conclusions: Vertically infected HIV children and adolescents show an increased thickness of EAT and IMT, expression of potentially increased CV risk. They also show an impaired systolic function.

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Biventricular diastolic function assessed by Doppler echocardiogram in children vertically infected with human immunodeficiency virus

Abstract: diastolic dysfunction occurred, individually or simultaneously, with no association with immune status; decreased myocardial compliance was predominant in the left ventricle, and abnormal relaxation in the right ventricle.

Cited by 3 publications

References 25 publications

Left ventricular hypertrophy in African children infected with HIV/AIDS: a case control study

Left ventricular hypertrophy in African children infected with HIV/AIDS: a case control study

Cardiovascular manifestations of HIV infection in children

Left Ventricular Function, Epicardial Adipose Tissue, and Carotid Intima-Media Thickness in Children and Adolescents With Vertical HIV Infection

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