Clinical utility of early amplitude integrated EEG in monitoring term newborns at risk of neurological injury

Toso, Paulina; González, Álvaro; Pérez, María Eugenia; Kattan, Javier; Fabres, Jorge; Tapia, José Luís; González, Hernán S.

doi:10.1016/j.jped.2013.07.004

Cited by 19 publications

(14 citation statements)

References 30 publications

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“…In addition, we found that the incidence of death in the neonatal period in the severely abnormal aEEG group (18/78, 23.1%) was significantly higher than in non‐severely abnormal aEEG group (4/153, 2.6%), which confirms that the severity of aEEG is associated with mortality . In short, early aEEG could predict not only short‐term outcomes but also long‐term outcomes in high‐risk infants …”

Section: Discussionsupporting

confidence: 91%

“…43 In short, early aEEG could predict not only short-term outcomes but also long-term outcomes in high-risk infants. 44,45 Of the 59 severely abnormal aEEG infants among the 84 infants in the adverse neurological outcome group, 43 (43/59 = 72.9%) infants had severely abnormal amplitude without SWC. In terms of death, CP, epilepsy, and retarded mental or psychomotor developmental, we also found an absence of SWC on aEEG recordings in the majority of infants.…”

Section: Discussionmentioning

confidence: 97%

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Prognostic value of amplitude‐integrated EEG in neonates with high risk of neurological sequelae

Xiao

Kang

Shi

et al. 2020

Ann Clin Transl Neurol

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Objective To determine the efficacy and the prognostic value of amplitude‐integrated electroencephalography (aEEG) in term and near‐term neonates with high risk of neurological sequelae. Methods Infants of ≥35 weeks of gestation diagnosed with neonatal encephalopathy or with high risk of brain injury were included. All eligible infants underwent aEEG within 6 h after clinical assessment. The infants were followed up 12 months to evaluate neurological development. Results A total of 250 infants were eligible, of which 85 had normal aEEG, 81 had mildly abnormal aEEG, and 84 had severely abnormal aEEG. Of these infants, 168 were diagnosed with different neonatal encephalopathies, 27 with congenital or metabolic diseases, and 55 with high risk of brain injury. In all, 22 infants died, 19 were lost to follow‐up, and 209 completed the follow‐up at 12 months, of which 62 were diagnosed with a neurological disability. Statistical analysis showed that severely abnormal aEEG predicted adverse neurological outcome with a sensitivity of 70.2%, a specificity of 87.1%, a positive predictive value of 75.6%, and a negative predictive value of 83.7%. Interpretation aEEG can predict adverse outcomes in high‐risk neonates and is a useful method for monitoring neonates with high risk of adverse neurological outcomes.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 97%

Prognostic value of amplitude‐integrated EEG in neonates with high risk of neurological sequelae

Xiao

Kang

Shi

et al. 2020

Ann Clin Transl Neurol

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“… 6 In this field, continuous brain monitoring through aEEG has been used in neonates to assess real-time brain function and for long periods, allowing a better classification of the encephalopathy severity, early detection of subclinical seizures and the monitoring of treatment response. 27 Abnormalities found in the aEEG early in life have strong predictive values of abnormal results at one year of age. 28 …”

Section: Discussionmentioning

confidence: 99%

“…6 Nesse campo, o monitoramento cerebral contínuo por aEEG tem sido aplicado em neonatos para avaliar a função cerebral em tempo real e por longos períodos, o que possibilita uma melhor classificação da gravidade de encefalopatia, a detecção de convulsões subclínicas precoces e o monitoramento da resposta ao tratamento. 27 Anormalidades encontradas no aEEG no início da vida têm fortes índices preditivos de resultados anormais com um ano. 28 …”

Section: Discussionunclassified

Espectroscopia de luz próxima ao infravermelho como ferramenta auxiliar no estudo do desenvolvimento infantil

Oliveira

Machado

Miranda

et al. 2015

Revista Paulista de Pediatria

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OBJECTIVE: To investigate the applicability of Near-Infrared Spectroscopy (NIRS) for cortical hemodynamic assessment tool as an aid in the study of child development. DATA SOURCE: Search was conducted in the PubMed and Lilacs databases using the following keywords: ''psychomotor performance/child development/growth and development/neurodevelopment/spectroscopy/near-infrared'' and their equivalents in Portuguese and Spanish. The review was performed according to criteria established by Cochrane and search was limited to 2003 to 2013. English, Portuguese and Spanish were included in the search. DATA SYNTHESIS: Of the 484 articles, 19 were selected: 17 cross-sectional and two longitudinal studies, published in non-Brazilian journals. The analyzed articles were grouped in functional and non-functional studies of child development. Functional studies addressed the object processing, social skills development, language and cognitive development. Non-functional studies discussed the relationship between cerebral oxygen saturation and neurological outcomes, and the comparison between the cortical hemodynamic response of preterm and term newborns. CONCLUSIONS: NIRS has become an increasingly feasible alternative and a potentially useful technique for studying functional activity of the infant brain.

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“…The initiation of hypothermia to babies with HIE who have moderate to severe abnormal aEEG patterns within the first 6 hours after birth positively affects the neurological outcomes. In a study which comparedcooled infants with non-cooled infants the positive predictive value of aEEG was low (64-75%) within 6 hoursafter birth; but it reached to 80% in both groups within 24-36 hours after birth [34] . In another study, it was reported that possibility of severe neurological damage was high (>80%) in patients having severe suppression in aEEG in the first 48 hours of life [35] .…”

Section: Effects Of Hypothermia On Aeeg Tracesmentioning

confidence: 94%

Cerebral Function Monitoring In Neonatal Intensive Care Units

Orman

Hakan

Aydın

2018

International Journal of Neurology Research

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hypothermia and for predict of their long-term neurological prognosis. The early aEEG traces of preterm infants also predict of their neurodevelopmental outcome. Current evidences demonstrated that aEEG is useful for define cerebral background activity, detect seizures, monitor treatment effects and predict neurodevelopmental outcomes of newborns. The main advantages of this device are its simplicity for both application and interpretation on one hand and the possibility of continuous long-term monitoring with real time assessment of clinical events on the other. CONCLUSION: aEEG is a safe and reliable method for the bedside monitoring of neonatal cerebral function and it can also provide information about long-term neurological prognosis.

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Clinical utility of early amplitude integrated EEG in monitoring term newborns at risk of neurological injury

Cited by 19 publications

References 30 publications

Prognostic value of amplitude‐integrated EEG in neonates with high risk of neurological sequelae

Prognostic value of amplitude‐integrated EEG in neonates with high risk of neurological sequelae

Espectroscopia de luz próxima ao infravermelho como ferramenta auxiliar no estudo do desenvolvimento infantil

Cerebral Function Monitoring In Neonatal Intensive Care Units

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