Clinical and epidemiological aspects related to the detection of adenovirus or respiratory syncytial virus in infants hospitalized for acute lower respiratory tract infection

Abstract

PCR can detect persistent/latent forms of ADV, an aspect to be considered when interpreting results. Additional studies with quantitative diagnostic techniques could elucidate the importance of the high frequency observed.

Eight Year Prospective Study of Adenoviruses Infections in Hospitalized Children. Comparison with Other Respiratory Viruses

“…As a result, children are often treated with antibiotics. These data are consistent with the literature [ 13 , 15 , 16 ]. In our series these clinical characteristics were more evident in single infections than in coinfections, but we have not found other groups that compare single and multiple infections.…”

“…In China, Jin et al, found HAdV in 6.3% of the infections in hospitalized and outpatient children [ 13 ]. In Argentina [ 14 ], the proportion increases to 14.3% in hospitalized children, very close to Brazilian hospitalized children [ 15 ] (15.8%). Our proportion is slightly higher (17%), possibly due to the prospective nature of our study, conducted in all hospitalized children, and not only in selected cases.…”

“…Some groups have performed comparisons between HAdV and RSV. In Brasil, Ferone et al [ 15 ] found in hospitalized infants, that children with HAdV infections are older than those with RSV, need antibiotic treatment more frequently and have fewer leukocytes and less C-reactive protein in their blood. Jin et al [ 13 ], in China, describe similar findings, that children with RSV are younger than patients with HAdV, and have lower respiratory tract infections such as bronchiolitis and bronchitis more frequently.…”

Relative frequency, Possible Risk Factors, Viral Codetection Rates, and Seasonality of Respiratory Syncytial Virus Among Children With Lower Respiratory Tract Infection in Northeastern Brazil

“…4,6 In Brazil, RSV is the most common viral pathogen found in episodes of LRTI; other frequent viruses include influenza, rhinovirus, parainfluenza, adenovirus, metapneumovirus, and bocavirus. [7][8][9][10][11][12][13][14][15][16] Some studies conducted in Brazil have suggested a clear seasonal pattern for RSV infections, with predominance from March to July, and a smaller number of cases in the summer months, especially November to February. [14][15][16][17][18][19] Other viruses have been investigated to a lesser extent, but a seasonal pattern was found for different respiratory viruses in Southern and Southeastern Brazil, where the winter is cold and dry.…”

Clinical and Virologic Characteristics May Aid Distinction of Acute Adenovirus Disease from Kawasaki Disease with Incidental Adenovirus Detection

“…H uman adenoviruses are responsible for 7%-8% of all pediatric respiratory illness 1 and can cause prolonged fever, elevated inflammatory markers, 2 and clinical features that mimic Kawasaki disease (KD). 3 Human adenoviruses are classified into 7 subgroups-designated "species" (A-G) based on genomic and biologic criteria.…”