Respiratory function in children of asthmatic mothers

Valadares, Marco A.; Gurgel, Ricardo Queiróz; Melo, Enaldo Vieira de; Guimarães, Alzira Maria D'avila Nery; Guedes, Kildane M.A.; Rocha, Neuly A.F.; Almeida, Maria Luíza Dória

doi:10.1016/j.jped.2013.03.007

Cited by 4 publications

(5 citation statements)

References 12 publications

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“…The immunological relationship between mother and foetus has an important role in the development of allergies and asthma in infants. Children born to mothers with moderate‐to‐severe uncontrolled asthma during pregnancy have a higher risk of developing asthma themselves and have more common lung function abnormalities 40‐43 . Here, we had the unique opportunity to evaluate the immunity of the newborn prior to disease onset.…”

Section: Discussionmentioning

confidence: 99%

“…Children born to mothers with moderate‐to‐severe uncontrolled asthma during pregnancy have a higher risk of developing asthma themselves and have more common lung function abnormalities. 40 , 41 , 42 , 43 Here, we had the unique opportunity to evaluate the immunity of the newborn prior to disease onset. Cord blood samples from babies born to asthmatic mothers were collected and immunophenotyped, representing the in utero immune environment.…”

Section: Discussionmentioning

confidence: 99%

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Cord blood group 2 innate lymphoid cells are associated with lung function at 6 weeks of age

et al. 2021

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Objective. Offspring born to mothers with asthma in pregnancy are known to have lower lung function which tracks with age. Human group 2 innate lymphoid cells (ILC2) accumulate in foetal lungs, at 10-fold higher levels compared to adult lungs. However, there are no data on foetal ILC2 numbers and the association with respiratory health outcomes such as lung function in early life. We aimed to investigate cord blood immune cell populations from babies born to mothers with asthma in pregnancy. Methods. Cord blood from babies born to asthmatic mothers was collected, and cells were stained in whole cord blood. Analyses were done using traditional gating approaches and computational methodologies (t-distributed stochastic neighbour embedding and PhenoGraph algorithms). At 6 weeks of age, the time to peak tidal expiratory flow as a percentage of total expiratory flow time (tPTEF/tE%) was determined as well as Lung Clearance Index (LCI), during quiet natural sleep. Results. Of 110 eligible infants (March 2017 to November 2019), 91 were successfully immunophenotyped (82.7%). Lung function was attempted in 61 infants (67.0%), and 43 of those infants (70.5% of attempted) had technically acceptable tPTEF/tE% measurements. Thirty-four infants (55.7% of attempted) had acceptable LCI measurements. Foetal ILC2 numbers with increased expression of chemoattractant receptorhomologous molecule (CRTh2), characterised by two distinct analysis methodologies, were associated with poorer infant lung function at 6 weeks of age." Conclusion. Foetal immune responses may be a surrogate variable for or directly influence lung function outcomes in early life.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cord blood group 2 innate lymphoid cells are associated with lung function at 6 weeks of age

et al. 2021

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“…This will be of interest as our cohort grows to an age where these measures can be evaluated. Children born to mothers with moderate to severe uncontrolled asthma during pregnancy are at increased risk of developing asthma and more commonly have lung function abnormalities [ 4 , 5 ]. However, studies have shown that with better asthma control during pregnancy and fewer exacerbations, there was a better respiratory health outcome for the children [ 86 , 87 ], suggesting that these pathways may be modified through improved maternal asthma management.…”

Section: Discussionmentioning

confidence: 99%

“…Asthma is the most common medical condition during pregnancy, with up to 45% of pregnant women with asthma requiring medical care for it [ 1 , 2 ]. Maternal asthma has been found to increase the risk of adverse neonatal outcomes, including respiratory complications [ 3 , 4 , 5 ], and it has been reported that prenatal exposure to air pollutants such as particulate matter, ozone, and nitrogen oxides increased the risk of transient tachypnea of the newborn, asphyxia, and respiratory distress syndrome [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Environmental Air Pollutants Inhaled during Pregnancy Are Associated with Altered Cord Blood Immune Cell Profiles

Gomes

Karmaus

Murphy

et al. 2021

IJERPH

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Air pollution exposure during pregnancy may be a risk factor for altered immune maturation in the offspring. We investigated the association between ambient air pollutants during pregnancy and cell populations in cord blood from babies born to mothers with asthma enrolled in the Breathing for Life Trial. For each patient (n = 91), daily mean ambient air pollutant levels were extracted during their entire pregnancy for sulfur dioxide (SO2), nitric oxide, nitrogen dioxide, carbon monoxide, ozone, particulate matter <10 μm (PM10) or <2.5 μm (PM2.5), humidity, and temperature. Ninety-one cord blood samples were collected, stained, and assessed using fluorescence-activated cell sorting (FACS). Principal Component (PC) analyses of both air pollutants and cell types with linear regression were employed to define associations. Considering risk factors and correlations between PCs, only one PC from air pollutants and two from cell types were statistically significant. PCs from air pollutants were characterized by higher PM2.5 and lower SO2 levels. PCs from cell types were characterized by high numbers of CD8 T cells, low numbers of CD4 T cells, and by high numbers of plasmacytoid dendritic cells (pDC) and low numbers of myeloid DCs (mDCs). PM2.5 levels during pregnancy were significantly associated with high numbers of pDCs (p = 0.006), and SO2 with high numbers of CD8 T cells (p = 0.002) and low numbers of CD4 T cells (p = 0.011) and mDCs (p = 4.43 × 10−6) in cord blood. These data suggest that ambient SO2 and PM2.5 exposure are associated with shifts in cord blood cell types that are known to play significant roles in inflammatory respiratory disease in childhood.

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“…24 In a recent study by Valadares et al, the aforementioned association was demonstrated by lung function changes in 30.3% of the children whose mothers had been diagnosed with asthma, an obstructive pattern being observed in 14%. 25 Therefore, a family history of asthma, particularly a maternal history of asthma, warrants preventive environmental measures, such as reducing exposure to aeroallergens and combating passive and active smoking. In addition, it assists in establishing a diagnosis of asthma.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with asthma expression in adolescents

et al. 2018

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Objective:To evaluate risk factors associated with asthma symptoms in adolescents in the 13- to 14-year age bracket. Methods:This was a cross-sectional study involving adolescents enrolled in randomly selected public schools in the city of Belo Horizonte, Brazil, and conducted with the use of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and its supplementary module for risk factor assessment. The ISAAC questionnaire was completed by the students themselves, whereas the supplementary questionnaire was completed by their parents or legal guardians. Variables showing p ≤ 0.25 in the univariate analysis were included in the multivariate analysis. Stepwise regression with backward elimination was used for variable selection. Results:We evaluated 375 adolescents, 124 (33.1%) of whom had asthma symptoms. The final multivariate analysis model revealed that asthma symptoms were associated with birth weight < 2,500 g (p < 0.001), day care center or nursery attendance (p < 0.002), maternal history of asthma (p < 0.001), contact with animals during the first year of life (p < 0.027), current contact with animals outside the home (dogs, cats, or farm animals; p < 0.005), and more than 20 cigarettes per day smoked by parents or other household members (p < 0.02). Conclusions:Exposure to animals in and outside the home is associated with asthma symptoms, as is environmental tobacco smoke exposure. Families, health professionals, and administrators of health care facilities should take that into account in order to prevent asthma and reduce asthma morbidity.

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Respiratory function in children of asthmatic mothers

Cited by 4 publications

References 12 publications

Cord blood group 2 innate lymphoid cells are associated with lung function at 6 weeks of age

Cord blood group 2 innate lymphoid cells are associated with lung function at 6 weeks of age

Environmental Air Pollutants Inhaled during Pregnancy Are Associated with Altered Cord Blood Immune Cell Profiles

Factors associated with asthma expression in adolescents

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