Oral Ibuprofen and the Patent Ductus Arteriosus: A New Approach to an Old Problem

Kluckow, Martin

doi:10.1016/j.jped.2013.02.002

Cited by 1 publication

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with term infants, the smooth muscle of ductus arteriosus in premature infants is relatively dysplastic, with a larger inner diameter, thinner wall and a lower sensitivity to oxygen partial pressure ( 10 ). In addition, the study of ( 11 ) has shown that gestational age and body mass are closely related to the occurrence of PDA.…”

Section: Discussionmentioning

confidence: 99%

Echocardiographic parameters predicting spontaneous closure of ductus arteriosus in preterm infants

Yang

Tian

et al. 2023

Front. Pediatr.

View full text Add to dashboard Cite

ObjectiveTo evaluate the value of echocardiographic parameters in predicting early spontaneous closure of ductus arteriosus in premature infants.Methods222 premature infants admitted to the neonatal ward of our hospital were selected, and patent ductus arteriosus was detected by echocardiography 48 h after birth. On the 7th day, whether the ductus arteriosus was closed naturally in this cohort was observed. The infants whose ductus arteriosus were not closed were identified as the PDA group (n = 109), and the other infants were included in the control group (n = 113). The echocardiographic parameters of the two groups of premature infants at 48 h after birth were single-factor statistically and Pearson correlation analyzed, and the parameters with statistically significant differences in single-factor analyzed were selected for multivariate logistic stepwise regression analysis.ResultsThe ductus arteriosus shunt velocity and the pressure difference between the descending aorta and the pulmonary artery (ΔPs) in the PDA group were lower than those in the control group (P < 0.05). The pulmonary artery pressure (PASP) in the PDA group was higher than that in the control group (P < 0.05). According to the multivariate logistic stepwise regression analysis, only the maximum shunt velocity of ductus arteriosus was correlated with early spontaneous closure of ductus arteriosus in 48 h first echocardiographic parameters (P = 0.049). The receiver operating characteristic (ROC) curve indicates the optimal critical point of echocardiographic ductus arteriosus shunt velocity in premature infants 48 h after birth was 1.165 m/s.ConclusionEchocardiographic parameters are of great value in predicting the early spontaneous closure of ductus arteriosus in premature infants. In particular, the ductus arteriosus shunt velocity is correlated with the early spontaneous closure of ductus arteriosus.

show abstract

Section: Discussionmentioning

confidence: 99%