Very early feeding in stable small for gestational age preterm infants: a randomized clinical trial

Arnon, Shmuel; Sulam, Daniella; Konikoff, Fred M.; Regev, Rivka; Litmanovitz, Ita; Naftali, Timna

doi:10.1016/j.jped.2012.12.004

Cited by 26 publications

(25 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar findings were reported in the study of Leaf et al 6 A meta-analysis also did not detect any statistically significant differences overall death (typical RR 1.06 (95% CI 0.55 to 2.05). 26 On the other hand, others studies showed that delaying enteral feeding could be detrimental. Parenteral nutrition is usually used as an alternative source of nutrients, but side effects are common 12 (Sepsis, Pulmonary embolism, metabolic complication, Cholestatic liver disease etc).…”

Section: Discussionmentioning

confidence: 99%

“…9 This approach has recognized benefits, including enhanced endocrine and exocrine hormonal activity, improved growth of intestinal mucosa, maturation of gut motility, and improved overall clinical outcome, with no proven increase in the relative risk of feeding intolerance or NEC. 25,26,27 Limitations of the study • Single centre study • Small sample size.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparative Study of Early Versus Delayed Enteral Feeding in Development of Necrotizing Enterocolitis for Preterm Small for Date Babies

Biswas¹,

Singha²,

Hoque³

et al. 2018

Bangladesh J Child Health

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparative Study of Early Versus Delayed Enteral Feeding in Development of Necrotizing Enterocolitis for Preterm Small for Date Babies

Biswas¹,

Singha²,

Hoque³

et al. 2018

Bangladesh J Child Health

View full text Add to dashboard Cite

show abstract

“…Enteral feeding should begin with trophic amounts of 20 to 30 mL/kg on day 1 and advanced as rapidly as tolerated, decreasing IV nutrition accordingly, while maintaining nutrient intakes at recommended rates [ 63 ]. Most studies now show that enteral feeding, particularly of maternal colostrum and milk, can start as early as the 1st day of life in relatively stable infants at rates as high as 20 to 30 mL/kg/day and can be advanced up to 30 to 40 mL/kg/day, advancing to full enteral feeding by 7 to 10 days, even in extremely preterm infants [ 64 65 ].…”

Section: Enteral Feedingmentioning

confidence: 99%

Nutritional Support Strategies for the Preterm Infant in the Neonatal Intensive Care Unit

Hay

2018

Pediatr Gastroenterol Hepatol Nutr

View full text Add to dashboard Cite

The goal of nutrition of the preterm infant is to “provide nutrients to approximate the rate of growth and composition of weight gain for a normal fetus of the same postmenstrual age and to maintain normal concentrations of blood and tissue nutrients” (American Academy of Pediatrics 2014). Failure to provide the necessary amounts of all of the essential nutrients to preterm infants has produced not only growth failure, but also increased morbidity and less than optimal neurodevelopment. This continues to be true despite many efforts to increase nutrition of the preterm infants. In contrast, enhanced nutrition of very preterm infants, both intravenous and enteral, beginning right after birth, promotes positive energy and protein balance and improves longer term neurodevelopmental outcomes. The benefits are long lasting too, particularly for prevention of later life chronic diseases.

show abstract

“…There are two methods of feeding preterm babies: enteral or parenteral nutrition. Table 1 highlights the advantages and disadvantages of the two methods of providing nutrition to neonates [2,[7][8][9].…”

Section: Challenges Of Feeding Growth Restricted Premature Babiesmentioning

confidence: 99%

“…Early feeding can also result in shorter duration of hospital stays and establishing of full enteral feeding earlier [7]. Due to the possible increased risk of NEC in premature IUGR babies, the introduction of enteral feeding is often delayed in most centers and it is not uncommon to see associated complications due to prolonged TPN use [4].…”

Section: Current Challenges and Evidence Initiation Of Feedsmentioning

confidence: 99%

Feeding growth restricted premature neonates: a challenging perspective

et al. 2018

View full text Add to dashboard Cite

Nutrition in the postnatal period is essential to achieve optimal growth and maintain biochemical normality. Feeding growth-restricted premature neonates remains a big challenge for pediatricians and neonatologists. The choice of milk is one of the biggest challenges. Breast milk is recommended, although feeding with preterm formulas can ensure a more consistent delivery of optimal levels of nutrients. The timing of introduction of feeds and the rate of advancement of those feeds in preterm infants are both topics of significant controversy. Early feeding is advantageous because it improves the functional adaptation of the gastrointestinal tract and reduces the duration of total parenteral nutrition. A faster rate of advancement will also reduce the duration of need for parenteral nutrition. Despite this, enteral feeding is often delayed and is often slowly increased in high-risk infants because of a possible increased risk of necrotizing enterocolitis (NEC). Growth-restricted neonates are at increased risk of developing NEC due to a combination of antenatal and postnatal disturbances in gut perfusion. If enteral feeding is introduced earlier and advanced more quickly, this may lead to increased risk of NEC, but slower feeds extend the duration of parenteral nutrition and its risks and may have adverse consequences for survival, growth, and development. Premature infants pose a significant nutritional challenge. Overall, we would suggest the preferential use of human breast milk, early minimal enteral feeds, and standardized feeding protocols with cautious advancements of feeds to facilitate gastrointestinal adaptation and reduce the risk of NEC, however further research is needed.

show abstract

Very early feeding in stable small for gestational age preterm infants: a randomized clinical trial

Abstract: Stable SGA preterm infants on a very early feeding regimen achieved full enteral feeding and were discharged home significantly earlier than those on a delayed regimen, with no excess morbidity.

Cited by 26 publications

References 15 publications

Comparative Study of Early Versus Delayed Enteral Feeding in Development of Necrotizing Enterocolitis for Preterm Small for Date Babies

Comparative Study of Early Versus Delayed Enteral Feeding in Development of Necrotizing Enterocolitis for Preterm Small for Date Babies

Nutritional Support Strategies for the Preterm Infant in the Neonatal Intensive Care Unit

Feeding growth restricted premature neonates: a challenging perspective

Contact Info

Product

Resources

About