Novel nanosystems for the treatment of ocular inflammation: Current paradigms and future research directions

Lalu, Lida; Tambe, Vishakha; Pradhan, Deepak; Nayak, Kritika; Bagchi, Suchandra; Maheshwari, Rahul; Kalia, Kiran; Tekade, Rakesh K.

doi:10.1016/j.jconrel.2017.07.035

Cited by 105 publications

(35 citation statements)

References 135 publications

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“…The eye irritation score is calculated by dividing the total score for all rabbits by the number of rabbits [1,18]. Irritation was classified according to four grades: practically non-irritating, score 0-3; slightly irritating, score [4][5][6][7][8]; moderately irritating, score [9][10][11][12]; and severely irritating (or corrosive), score 13-16 (IAEC approval for the tests was obtained Ref No; CPCSEA/IAEC/P'ceutics-33/2017-18/132).…”

Section: Ocular Irritancy Testmentioning

confidence: 99%

“…These are binary systems, especially made up monoolein-water and are three-dimensional nanostructure with hydrophobic and hydrophilic domains that can self-order into thermodynamically stable bicontinuous cubic liquid crystalline phases [8]. These are capable of loading and enhancing the penetration of lipophilic, hydrophilic, and amphiphilic drugs [9].…”

Section: Introductionmentioning

confidence: 99%

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Ocular delivery of natamycin based on monoolein/span 80/poloxamer 407 nanocarriers for the effectual treatment of fungal keratitis

Kazi¹,

Dhakne²,

Dehghan³

2020

jrp

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A 3 2 factorial design was used to develop Natamycin cubosome nanoparticles with enhanced corneal permeation, so as to effectively treat ocular fungal keratitis. Probe sonication technique was deployed to disperse the dry lipidic film to obtain colloidal dispersion. The colloidal dispersion was characterized for critical quality attributes such as particle size, poly dispersibility index (PDI), zeta potential and entrapment efficiency. The optimized batch exhibited a particle size of 158.2 nm, zeta potential-40 mV, PDI 0.328 in addition, entrapment efficiency of 99.85%. The in vitro drug release of natamycin from optimized cubosome demonstrated a cumulative %drug release of 84.29% at the end of 8 hours. The optimized cubosomal dispersion exhibited enhanced in vitro antifungal activity against Candida albicans and Aspergillus fumigatus as compared to a pure drug suspension. The optimized formulation was further analyzed for polarized light microscopy (PLM), transmission electron microscopy (TEM) and small angle Xray scattering (SAXS) to state the morphology of formed cubosome nanoparticles and was noted to be Im3m bicontinous cubic mesophasic structure. X-ray diffraction (XRD) studies affirmed the complete encapsulation of natamycin into cubosome vesicles. Ex vivo corneal permeation studies of optimized formulation revealed enhanced corneal permeation in comparison to a pure drug suspension. The ocular irritation studies performed on rabbits indicated the cubosome to be non-irritant. Finally, the developed natamycin cubosome nanoparticles demonstrated sustained drug release and increased corneal penetration. Thus, these cubosome nanocarriers present a propitious delivery system for effective management of ocular fungal keratitis.

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Section: Ocular Irritancy Testmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ocular delivery of natamycin based on monoolein/span 80/poloxamer 407 nanocarriers for the effectual treatment of fungal keratitis

Kazi¹,

Dhakne²,

Dehghan³

2020

jrp

View full text Add to dashboard Cite

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“…Micelle solubilization had been used for stability and bioavailability enhancement of poorly soluble and practically insoluble drugs (Lalu et al., 2017; Mandal et al., 2017; Song et al., 2018). However, the development of micelle eyedrops is severely restricted by nanocarriers (Song et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

Ultra-small micelles based on polyoxyl 15 hydroxystearate for ocular delivery of myricetin: optimization, in vitro, and in vivo evaluation

et al. 2019

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2019) Ultra-small micelles based on polyoxyl 15 hydroxystearate for ocular delivery of myricetin: optimization, invitro, and invivo evaluation, Drug Delivery, 26:1, 158-167, ABSTRACT The aim was to develop a nanocarrier based on polyoxyl 15 hydroxystearate (KolliphorV R HS15, HS15) micelles for the solubility, stability, and ocular delivery of myricetin (Myr). An optimized ratio of HS15 and Myr was prepared to fabricate HS15-Myr micelle ophthalmic solution. Myr-encapsulating HS15 micelles (HS15-Myr micelles) were subjected to physicochemical characterizations. The chemical stability of Myr in HS15 micelles and storage stability of HS15-Myr micelle ophthalmic solutions were evaluated. In vitro parallel artificial membrane permeability assay and antioxidant activity of Myr in HS15 micelles were also measured. In vivo ocular tolerance, corneal permeation, and anti-inflammatory efficacy studies were conducted following ocular topical administration. HS15-Myr micelles were successfully prepared and presented transparent appearance with high encapsulation (96.12 ± 0.31%), ultra-small micelle size (a mean diameter of 12.17 ± 0.73 nm), uniform size distribution (polydispersity index [PDI] ¼ 0.137 ± 0.013), and negative surface charge (À [4.28 ± 0.42] mV). Myr in HS15 micelle solution demonstrated higher aqueous stability than the free Myr solution among the accepted pH range for eyedrops. HS15-Myr micelle ophthalmic solution demonstrated high storage stability at 4 C and 25 C. HS15 micelles could significantly improve in vitro antioxidant activity and faster membrane permeation of Myr. No irritations or corneal damage were revealed in rabbit eyes after ocular administration of HS15-Myr micelle solution.In vivo corneal permeation study demonstrated that HS15-Myr micelles could penetrate the cornea efficiently in mouse eyes. Further, HS15-Myr micelles also demonstrated significant in vivo anti-inflammatory activity. It can be concluded that HS15 micelles are a potential ophthalmic delivery nanocarrier for poorly soluble drugs such as Myr. ARTICLE HISTORY

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“…Nanotechnology-based systems for treating and managing various ocular diseases include more accessible formulations for deeper segments of the eyes, which enable the availability of drugs at required site in a required amount without inversely affecting the eye tissues (Lalu et al 2017). Findings related to topical application of lipid-based systems (MEs, NEs, liposomes and solid lipid NPs), polymeric systems (hydrogels, contact lenses, polymeric NPs and dendrimers) and used physical methods (iontophoresis and sonophoresis) was reviewed by Souza et al (2014).…”

Section: Nanoemulsions For Ocular Drug Deliverymentioning

confidence: 99%

Bio-Based Nanoemulsion Formulations Applicable in Agriculture, Medicine, and Food Industry

Jampílek

Kráľová

Campos

et al. 2019

Nanobiotechnology in Bioformulations

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Nanotechnology providing "a new dimension" accompanied with new properties conferred to many current materials is widely used for production of a new generation of agrochemicals, in medicine it enables improved drug bioavailability, reducing undesirable side effects, minimizing non-specific uptake and specific targeting to certain target cells, while in food industry it has great importance in food protection and biofortification of food with valuable ingredients. In biobased nanoemulsions belonging to lipid nanocarriers plant oils used for oil phase, emulsifiers, biosurfactants, cosurfactants, targeting ligands on the surface of nanoemulsion (e.g., folate) or encapsulated active ingredients are of natural origin. The biocomponents of such nanoemulsions show low toxicity to living organisms, could protect encapsulated compounds for degradation, ensure their sustainable release and reduce the amount of active ingredient necessary for required effect. This chapter presents a comprehensive current overview of recent findings in the field of nanoemulsions and their utilization in agriculture and food industry, with the main emphasis on formulations encapsulating essential oils or plant extracts suitable as effective pesticide preparations as well as medicinal applications of bio-based nanoemulsions, where attention is paid to transdermal nanoemulsion formulations, the use of nanoemulsions in cancer therapy and for pulmonary and ocular drug delivery. Nanoemulsions formulated with natural emulsifiers, biosurfactants and biopolymers are presented and bio-based nanoemulsions of essential oils and their constituents as well as nanoemulsions with encapsulated vitamins, fatty acids and some bioactive compounds are discussed. Applications of nanoemulsions in edible coatings are outlined as well.

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Novel nanosystems for the treatment of ocular inflammation: Current paradigms and future research directions

Cited by 105 publications

References 135 publications

Ocular delivery of natamycin based on monoolein/span 80/poloxamer 407 nanocarriers for the effectual treatment of fungal keratitis

Ocular delivery of natamycin based on monoolein/span 80/poloxamer 407 nanocarriers for the effectual treatment of fungal keratitis

Ultra-small micelles based on polyoxyl 15 hydroxystearate for ocular delivery of myricetin: optimization, in vitro, and in vivo evaluation

Bio-Based Nanoemulsion Formulations Applicable in Agriculture, Medicine, and Food Industry

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