Assembled microneedle arrays enhance the transport of compounds varying over a large range of molecular weight across human dermatomed skin

Verbaan, FJ; Bal, Suzanne M.; Berg, Dirk–Jan van den; W, Groenink; Verpoorten, H; Lüttge, Regina; Bouwstra, J.A.

doi:10.1016/j.jconrel.2006.11.009

Cited by 184 publications

(99 citation statements)

References 31 publications

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“…Gomaa et al [53] highlighted an earlier study by Chilcott's group [62] which suggested that TEWL cannot be used to predict transdermal delivery of drugs [63]. No correlation between TEWL and skin integrity was found, however this may be due to the use of different experimental protocols.…”

Section: Transepidermal Water Loss (Tewl) Monitoringmentioning

confidence: 99%

Microneedle characterisation: the need for universal acceptance criteria and GMP specifications when moving towards commercialisation

Lutton

Moore

Larrañeta

et al. 2015

Drug Deliv. and Transl. Res.

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Section: Transepidermal Water Loss (Tewl) Monitoringmentioning

confidence: 99%

Microneedle characterisation: the need for universal acceptance criteria and GMP specifications when moving towards commercialisation

Lutton

Moore

Larrañeta

et al. 2015

Drug Deliv. and Transl. Res.

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“…Verbaan and coworkers found that the inherent elasticity of the epidermis typically resists puncture; as a consequence, the penetration depth is generally markedly less than the height of the actual microneedle [24]. They highlighted the disparity between the needle capability and potential puncture dynamics with needles with lengths of 300, 550, 700, and 900 microns.…”

Section: Resultsmentioning

confidence: 99%

“…They highlighted the disparity between the needle capability and potential puncture dynamics with needles with lengths of 300, 550, 700, and 900 microns. The 300 micron needles repeatedly failed to overcome the elastic deformation of the skin barrier and adequately puncture human skin [24]. The dimensions of the needle highlighted in Figure 2B are 800 microns long and, on the basis of Verbaan's work, sufficiently large that, to unprotected skin, would indeed constitute a puncture hazard [24].…”

Section: Resultsmentioning

confidence: 99%

“…The 300 micron needles repeatedly failed to overcome the elastic deformation of the skin barrier and adequately puncture human skin [24]. The dimensions of the needle highlighted in Figure 2B are 800 microns long and, on the basis of Verbaan's work, sufficiently large that, to unprotected skin, would indeed constitute a puncture hazard [24]. There will be some clear variations from one person to another, and age-related changes in skin will also influence the elasticity of the skin [25,26].…”

Section: Resultsmentioning

confidence: 99%

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Microneedle Manufacture: Assessing Hazards and Control Measures

Martin

McConville

Anderson

et al. 2017

Safety

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Transdermal microneedles have captured the attention of researchers in relation to a variety of applications, and silicone-based moulds required to produce these systems are now widely available and can be readily manufactured on the lab bench. There is however some concern over the potential for accidental needlestick injuries and, as with any sharp hazard, the potential for blood-borne pathogen transmission must be considered. This follows from recent governmental concerns over the use of microneedle systems in dermabrasion. Despite the piercing nature of the microneedle patch sharing many similarities with conventional hypodermic needles, there are notable factors that mitigate the risk of contamination. A range of microneedle systems has been prepared using micromoulding techniques, and their puncture capability assessed. A critical assessment of the potential for accidental puncture and the control measures needed to ensure safe utilisation of the patch systems is presented.

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“…The Schematic diagram of solid and hollow microneedles. (2005) d. Teo et al (2005) e. Xie et al (2005) f. Wu et al (2007) g. Khumpuang et al (2007) h. Verbaan et al (2007) Optimization Function, g (-)…”

Section: Acknowledgmentmentioning

confidence: 99%

Optimization of square microneedle arrays for increasing drug permeability in skin

Al-Qallaf

Das

2008

Chemical Engineering Science

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Microneedles array is a new transdermal drug delivery technique designed to create holes in 15 the epidermis and penetrate the stratum corneum, thus avoiding the high resistance of this barrier. Microneedles have been shown to increase the skin permeability of drugs with no or little pain. However, the skin permeability of epidermis while using microneedle arrays has yet to be fully studied. In some cases, microneedle and microneedle array designs which were developed based on certain criteria (e.g., material of the microneedles) have to 20 be related to other criteria (e.g., drug permeability in skin, skin thickness, etc). Therefore, in order to determine the optimum design of the microneedle arrays, the effect of different factors (e.g., number of the microneedle, surface area of the patch, etc) along with skin permeability by using microneedles should be determined accurately. In this work, an optimization framework for transdermal delivery of high molecular weight drug from 25 microneedle is presented. The outputs of this framework have allowed us to identify the optimum design of various microneedles. Data from this optimization algorithm is then used to predict skin permeability of high molecular weight injected into the skin from a microneedle system. The effect of the optimized micro-needles on blood drug concentration has been determined. The outcome of this study is useful to propose an optimum design 30 based on different measurement (e.g., variation of skin thickness) for transdermal delivery of drugs.

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Assembled microneedle arrays enhance the transport of compounds varying over a large range of molecular weight across human dermatomed skin

Cited by 184 publications

References 31 publications

Microneedle characterisation: the need for universal acceptance criteria and GMP specifications when moving towards commercialisation

Microneedle characterisation: the need for universal acceptance criteria and GMP specifications when moving towards commercialisation

Microneedle Manufacture: Assessing Hazards and Control Measures

Optimization of square microneedle arrays for increasing drug permeability in skin

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