Efficacy of Baccharis dracunculifolia in the treatment of diversion colitis in rats

Lima, Arthur Medeiros; Nascimento, Carlos Eduardo Costa; Santos, Carlos Henrique Marques dos; Dourado, Doroty Mesquita; Siqueira, Gabriel Elias Cardoso; Rigo, Giovana Maria; Bernardi, Lauren; Leonel, Paulo Otávio Souza; Matias, Rosemary; Ferreira, Vitor Caldas; Souza, Vítor Cruz Rosa Pires de

doi:10.1016/j.jcol.2019.09.001

Cited by 5 publications

(4 citation statements)

References 20 publications

(18 reference statements)

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“…Rats colostomy patients were treated for 21 days with an intrarectal infusion of B. dracunculifolia extract that reduced inflammation (from 2.7 to 2.1 on a scale ranging from 0 to 3). Still, they did not change vascular congestion in the excluded segment ( Lima et al, 2020 ).…”

Section: Pharmacology and Bioactivitymentioning

confidence: 84%

“…The results demonstrate that biocompatible liposomes improve the B. dracunculifolia extract anti-inflammatory action in vivo (Figueiredo-Rinhel et al, 2019). Lima et al (2020) evaluated the efficacy of the ethanolic extract of B. dracunculifolia leaves in treating diversion colitis, a complication of intestinal transit diversion. Rats colostomy patients were treated for 21 days with an intrarectal infusion of B. dracunculifolia extract that reduced inflammation (from 2.7 to 2.1 on a scale ranging from 0 to 3).…”

Section: Extractmentioning

confidence: 99%

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Ethnomedicinal, phytochemical and pharmacological investigations of Baccharis dracunculifolia DC. (ASTERACEAE)

et al. 2022

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Baccharis dracunculifolia DC (Lamiaceae) (Asteraceae) is found in South America, mainly in Argentina, Brazil, Bolivia, Paraguay and Uruguay. Folk medicine is used as a sedative, hypotensive, bronchodilator, cardiovascular disorders, anti-flu, and also in skin wounds. Considered the main source of green propolis, which increases the pharmacological interest in this species. It is also known as a “benefactor” plant facilitating the development of other plant species around it, being indicated for the recovery of degraded areas. This species has been studied for decades in order to isolate and identify the active principles present in the aerial parts (leaves and flowers) and roots. The present study consists of a review of the scientific literature addressing the ethnobotanical, ethnomedicinal, phytochemical, pharmacological and potential cytotoxic effects of the B. dracunculifolia species. In this survey, we sought to investigate issues related to the botanical and geographic description of the species, the ethnobotanical uses, as well as the phytochemical studies of the essential oil, extracts and green propolis obtained from the aerial parts and roots of B. dracunculifolia. Using high precision analytical tools, numerous compounds have already been isolated and identified from leaves and flowers such as the flavonoids: naringenin, acacetin, dihydrokaempferol, isosakuranetin and kaempferide; phenolic acids: p-coumaric, dihydrocoumaric, ferulic (E)-cinnamic, hydroxycinnamic, gallic, caffeic, and several caffeoylquinic acids derivatives; phenolic acids prenylated: artepillin C, baccharin, drupanin; the glycosides dracuculifosides and the pentacyclic triterpenoids: Baccharis oxide and friedelanol. The predominant class in the essential oil of leaves and flowers are terpenoids comprising oxygenated monoterpenes and sesquiterpenes, highlighting the compounds nerolidol, spathulenol, germacrene D and bicyclogermacrene. These compounds give the species high antimicrobial, antioxidant, antitumor, analgesic, immunomodulatory and antiparasitic potential, making this species a promising herbal medicine. In vitro toxicity assays with B. dracunculifolia extract showed low or no cytotoxicity. However, in vivo analyses with high doses of the aqueous extract resulted in genotoxic effects, which leads us to conclude that the toxicity of this plant is dose-dependent.

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Section: Pharmacology and Bioactivitymentioning

confidence: 84%

Section: Extractmentioning

confidence: 99%

Ethnomedicinal, phytochemical and pharmacological investigations of Baccharis dracunculifolia DC. (ASTERACEAE)

et al. 2022

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“…Otro antecedente de la actividad anti-inflamatoria de B. dracunculifolia ha sido reportado en un modelo de ratas sometidas a colostomía. El extracto administrado con una infusión intrarrectal disminuyó el proceso inflamatorio asociada a la colitis de exclusión 31 .…”

Section: Actividad Anti-inflamatoria En Modelos In Vivounclassified

Immunomodulatory activity of species of the genus Baccharis

Burgos

Alfonso

Ferro

et al. 2022

Rev. parag. reumatol

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Productos de origen natural como aquellos derivados de plantas y microorganismos están reemergiendo como una rica fuente de nuevos compuestos activos para el desarrollo de nuevas drogas terapéuticas 1 . Las plantas medicinales son todas aquellas utilizadas como parte de las tradiciones y costumbres de una comunidad y capaces de aliviar enfermedades, por lo mismo, las mismas desempeñan un rol importante en el ámbito de la salud humana 2 .Diversas enfermedades involucran procesos inflamatorios, tales como enfermedades autoinmunes, Revisión

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“…[3][4][5] However, most of these studies were performed in murine models. [6][7][8] For this reason, we evaluated the effects of three different species of the Baccharis genus (B. trimera, B. punctulata, B. notosergila) on human peripheral blood mononuclear cells (PBMCs). Cells were evaluated for phytohemagglutinin (PHA)-induced proliferation and the production of a relevant cytokine, interferon gamma (IFN-γ), by these cells.…”

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confidence: 99%

Immunomodulatory Effects of Three Species of Baccharis on Human Peripheral Blood Mononuclear Cells

2021

TJNPR

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Baccharis species of the Asteraceae family are widely distributed in South America and are popularly known as "carqueja" or "jaguarete ka'a". The aerial parts of these plants are used in folk medicine not only to treat gastrointestinal and liver diseases, but also inflammatory processes. 1,2 Extracts and compounds with activity on the immune system, or immunomodulators, are of great interest due to the therapeutic potential, mainly in pathologies that involve inflammation. The genus Baccharis has demonstrated diverse biological activities, including immunomodulatory activity. 3 Among the species with reported antiinflammatory activity, B. dracunculifolia and B. trimera are the most studied. [3][4][5] However, most of these studies were performed in murine models. [6][7][8] For this reason, we evaluated the effects of three different species of the Baccharis genus (B. trimera, B. punctulata, B. notosergila) on human peripheral blood mononuclear cells (PBMCs). Cells were evaluated for phytohemagglutinin (PHA)-induced proliferation and the production of a relevant cytokine, interferon gamma (IFN-γ), by these cells. This study reveals new properties of methanolic extracts of B. trimera, B. punctulata and B. notosergila in an in vitro model of human inflammatory response.

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Efficacy of Baccharis dracunculifolia in the treatment of diversion colitis in rats

Cited by 5 publications

References 20 publications

Ethnomedicinal, phytochemical and pharmacological investigations of Baccharis dracunculifolia DC. (ASTERACEAE)

Ethnomedicinal, phytochemical and pharmacological investigations of Baccharis dracunculifolia DC. (ASTERACEAE)

Immunomodulatory activity of species of the genus Baccharis

Immunomodulatory Effects of Three Species of Baccharis on Human Peripheral Blood Mononuclear Cells

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