Prevalence of anti-tissue transglutaminase antibodies in patients with irritable bowel syndrome in Duhok city

Abstract

Background Irritable bowel syndrome (IBS) is a common gastrointestinal disorder; celiac disease is an autoimmune enteropathy that can mimic any functional gastrointestinal disorder. The aim of this study is to estimate the prevalence of celiac disease antibodies (anti Tissue Transglutaminase—tTG) in patients with irritable bowel syndrome. Patients and methods This cross sectional study was conducted on 70 patients with irritable bowel syndrome fulfilling Rome III criteria who visited Azadi Teaching Hospital in Duhok city—Iraq. Patients were classified according to irritable bowel syndrome subtypes into: Diarrhoea Predominant (D-IBS), Constipation Predominant (C-IBS) and Mixed (M-IBS). IgA and IgG anti tTG were used to screen patients for celiac disease. Results A total number of 70 patients (44 females and 26 males) were included; their mean age was 33 years (SD ± 7.64). Five patients (7.1%) were found to have positive both IgA and IgG anti tTG. Three of them have had D-IBS and the other two had C-IBS. No one of the M-IBS patients tested positive. Conclusion The prevalence of anti tTG antibodies in irritable bowel syndrome is high. Patients with D-IBS should be screened for celiac disease.

Impactos da Síndrome do Intestino Irritável associada à ansiedade e depressão na qualidade de vida da população

“…O diagnóstico ainda é baseado apenas na apresentação clínica por ser uma fisiopatologia incompletamente compreendida, no entanto, critérios foram propostos para auxiliar os profissionais da saúde na investigação e são chamados de "critérios de Roma". Nesse método, foram definidos subtipos de constipação: tipo predominante de diarreia, tipo misto e subtipado, ou seja, os hábitos intestinais são avaliados em dois níveis, tendo em consideração a frequência e o aspecto das fezes para que assim um diagnóstico preciso seja feito (Mohammad, B & Al-dohouky, L & Mohammed, A, 2019) (Mendonça et al, 2020) O tratamento da Síndrome do intestino irritável não possui um padrão, pois envolve tanto a abordagem terapêutica, quanto a farmacológica além da mudança de estilo de vida que é imprescindível. Dessa maneira, vale ressaltar que por ser uma doença que possui somatização de várias é de difícil diagnóstico.…”

Screening for Celiac Disease in Patients with Irritable Bowel Syndrome Fulfilling Rome III Criteria

“…25 Recently, Mohammad et al from Iraq detected 5 seropositive patients for CD (7.1%) in a sample of 70 patients with IBS fulfilling the Rome III criteria. 26 This variation in results might be ascribed to different geographical locations, racial differences, study characteristics, sample size, and selection bias.…”

Biomarkers in Irritable Bowel Syndrome: Biological Rationale and Diagnostic Value

“…Patients diagnosed with mixed bowel habits (IBS-M) did not give a positive result. Moreover, in patients with IBS-D, the possibility of celiac disease should be ruled out [23].…”