Epidemiological profile and clinical characteristics of patients with intestinal inflammatory disease

Abstract

According to several epidemiological studies, there is a significant increase in cases of inflammatory disease in developing countries. Objective To describe epidemiological data and clinical features of patients with inflammatory bowel disease in patients enrolled in Campo Grande, MS. Method A retrospective descriptive study with a database analysis of patients who were enrolled and renewed their process in the Exceptional Medications Program of the Health Department from January 2008 to December 2016. Results 423 patients participated in the study, 260 women and 163 men. Of these, 238 patients had Crohn's disease and 185 had ulcerative rectocolitis. The patients’ mean age was 46 years. The most commonly used medication for both diseases was mesalazine and 34.3% of the patients needed to switch their medication during the treatment, most of them with Crohn's disease. In Crohn's patients, the most affected segment was the colon (40.6%) and in patients with ulcerative rectocolitis the entire large intestine was involved (78.8%) was more common. Of the total number of patients, 10.8% of the women and 18.4% of the men needed to use an anti-TNF. Conclusion Most people on treatment for IBD are female, with a mean age of 46 years and suffering from Crohn's disease. The most affected segments were the entire large intestine in URC cases and the colon in Crohn's disease cases. Mesalazine was the most used drug in both diseases. There was more drug replacement in Crohn's disease patients. In Crohn's disease, younger patients used infliximab more frequently.

Review of the epidemiology and burden of ulcerative colitis in Latin America

“…In 11 studies, the greatest proportion of patients had extensive (pancolitis). 10 , 17 , 21 – 24 , 27 – 30 , 33 In a nationwide study in Mexico, which separated UC extension by age group, pancolitis was the most frequent extension of UC in children (64.4%), adult (62.2%) and elderly (57.7%) patients; distal/proctosigmoiditis was the second most frequent extension in children (22.2%), adult (24.8%) and elderly (26.8%) patients; and left-sided colitis was the least frequent extension in children (13.3%), adult (13.0%) and elderly (15.6%) patients. 27 , 28 In line with this, the highest proportion of patients (43%) had pancolitis in a study in Argentina.…”

Reações adversas no tratamento da doença inflamatória intestinal em um Ambulatório de Referência / Adverse reactions in inflammatory bowel disease treatment in a Reference Center

“…Dos resultados analisados, em relação a distribuição dos diagnósticos entre os espectros da DII, houve maior proporção de DC na população estudada, discordando do perfil epidemiológico de pacientes do Espírito Santo e de outros estados do Brasil, onde a prevalência de RCU é maior (63,84%) (3,14) . A amostra estudada foi concordante com perfis epidemiológicos do território brasileiro quanto à prevalência por sexo, maior em mulheres (61,5%) (4,13) .…”

“…A incidência possui um padrão bimodal, atingindo tanto adultos jovens, dos 20 aos 40 anos, quanto idosos a partir dos 55 anos. Acomete predominantemente indivíduos brancos e tem distribuição similar em ambos os sexos, com prevalência aumentada no sexo feminino na DC (4) .…”

Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study

“…[50]One study found a higher prevalence of left-sided colitis, higher mortality, and higher usage of biological agents in Mexican population than in Mexican-American population, supporting the role of environmental factors on clinical characteristics of IBD. [24] The larger case-series in LAC Countries are from 1946 to date are from Argentina [14,51,52], Barbados [13], Brazil [14,[53][54][55][56][57][58][59][60][61][62][63][64][65], Chile [66][67][68], Cuba [69], Peru [70,71], Puerto Rico [72][73][74][75] and Uruguay. [76][77][78] Most CD localizations were ileal-colonic and CD behavior was mostly inflammatory, followed by penetrant or stenotic.…”