Analysis of neutrophil–lymphocyte ratio as a prognostic element in the response to neoadjuvant therapy in rectal cancer

Polli, Leonardo V.; Pinho, Mauro

doi:10.1016/j.jcol.2015.01.003

Cited by 2 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, Ishihara et al indicated that radiation-induced apoptosis of peripheral blood lymphocytes may be predictive for histological regression of rectal cancer in response to preoperative chemoradiotheapy [6]. However, in a more recent study, Polli and Pinho reported that they could not demonstrated a significant relationship between complete tumor response and peripheral leukocyte parameters [9]. In our study, we have observed a marked reduction in the peripheral lymphocyte count as Ishihara emphasized due to radiationinduced apoptosis after CRT.…”

Section: Discussionsupporting

confidence: 40%

Is there a relation between the changes in circulating lymphocyte counts due to neoadjuvant chemoradiotherapy and intratumoral lymphocytic response and tumor regression grade in locally advanced rectal cancers?

Yaşar¹,

Badak²,

Özen³

et al. 2017

Med-Science

View full text Add to dashboard Cite

There are controversies about the relation between the peripheral lymphocyte levels and response to neoadjuvant therapy. While some authors have reported that a positive correlation between peripheral lymphocyte levels and tumor response, others have suggested the opposite. In the present study, we aimed to investigate the possible relations between the changes in circulating lymphocyte counts due to neoadjuvant chemoradiotherapy (CRT) and intratumoral lymphocytic response (ILR) and tumor regression grade (TRG) in locally advanced rectal cancers. Lymphocyte levels before, during and after CRT as well as before surgery and pathologic findings including ILRs and TRGs were recorded. Lymphocyte levels before CRT were accepted as absolute values. After the changes in the lymphocyte levels during and after CRT and before the surgery were recorded as ratios to the absolute values, the relation between the changes in lymphocyte levels, ILR and TRG were studied by using Pearson and Spearman correlation tests. There was a positive correlation between changes in peripheral lymphocytic levels after neoadjuvant CRT and ILRs. However, there were no other correlations between changes in lymphocytic levels and TRGs and ILRs. The changes in the peripheral lymphocyte counts after CRT may be predictive for ILR. Further studies may provide more information about the relation between peripheral lymphocytes and TILs and tumor response to neoadjuvant CRT.

show abstract

Section: Discussionsupporting

confidence: 40%

Is there a relation between the changes in circulating lymphocyte counts due to neoadjuvant chemoradiotherapy and intratumoral lymphocytic response and tumor regression grade in locally advanced rectal cancers?

Yaşar¹,

Badak²,

Özen³

et al. 2017

Med-Science

View full text Add to dashboard Cite

show abstract

“…The pCR is defined according to both tumor and lymph nodes presenting sensitivity to treatment (14,15). It is even useful in cases without response to discontinuing the treatment or increasing the intensity to achieve response and improvement in prognosis (16)(17)(18)(19)(20). Contributing factors for pCR include CEA level, anal verge distance, peripheral extension, smoking status, lymph node status, grade, size less than 5 cm, and time interval to surgery (21,22).…”

Section: Introductionmentioning

confidence: 99%

Association Between Pathological Complete Response and Tumor Location in Patients with Rectal Cancer After Neoadjuvant Chemoradiotherapy, a Prospective Cohort Study

Novin¹,

Saneii²,

Noori³

et al. 2021

Int J Cancer Manag

View full text Add to dashboard Cite

Background: Colorectal cancers are the third common malignancies after lung and breast neoplasms. Some contributing factors for pathological complete response (pCR) to neoadjuvant therapy of rectal cancer have been defined. Despite various studies in this era, there are few studies on the location of tumors. Objectives: Regarding the high prevalence of colorectal cancer in Iran and the importance of neoadjuvant chemoradiation for survival and morbidity, this study was carried out to determine the association between pathologic complete response and tumor location in patients with rectal cancer after neoadjuvant chemoradiotherapy. Methods: In this prospective cohort, 100 cases with rectal adenocarcinoma from 2017 to 2019 were enrolled. Distance between anal verge and tumor was measured by clinical examination, colonoscopy, endo-sonography, and MRI. Tumors were defined as distal (less than 5 cm from the anal verge) and none distal (more than 5 cm from the anal verge). Another subdivision was inferior (0 - 4.99 cm), middle (5 - 9.99 cm), and superior (10 - 15 cm). The pathological response was compared across the groups. Results: In this study, the pCR was seen in 30%. In univariate analysis body mass index (BMI), grade, N-stage, and distance from anal verge were related to pCR. In cases with BMI over 25 kg/m2 and in tumors with low to medium grade N0/N1, and distance less than 5 cm from the anal verge (low lying tumors) the pCR to neoadjuvant treatment was higher. In multivariate analysis tumor grade, N stage, and distance from anal verge were still related to pCR. Conclusions: According to the obtained results in this study, there may be some association between rectal tumor location and pathologic complete response.

show abstract

Analysis of neutrophil–lymphocyte ratio as a prognostic element in the response to neoadjuvant therapy in rectal cancer

Cited by 2 publications

References 8 publications

Is there a relation between the changes in circulating lymphocyte counts due to neoadjuvant chemoradiotherapy and intratumoral lymphocytic response and tumor regression grade in locally advanced rectal cancers?

Is there a relation between the changes in circulating lymphocyte counts due to neoadjuvant chemoradiotherapy and intratumoral lymphocytic response and tumor regression grade in locally advanced rectal cancers?

Association Between Pathological Complete Response and Tumor Location in Patients with Rectal Cancer After Neoadjuvant Chemoradiotherapy, a Prospective Cohort Study

Contact Info

Product

Resources

About