Clinical and epidemiological evaluation of patients with sporadic colorectal cancer

Fernandes, Gláucia Maria de Mendonça; Leme, Cássia Veridiana Dourado; Ruiz-Cintra, Mariângela Torreglosa; Pavarino, Érika Cristina; Netinho, João Gomes; Goloni-Bertollo, Eny Maria

doi:10.1016/j.jcol.2014.08.001

Cited by 6 publications

(4 citation statements)

References 31 publications

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“…The characteristics of clinical symptoms of CRC may be the occurrence of intestinal obstruction, hemorrhage (hematochezia, enterorrhagia), changes in bowel habits, and systemic effects such as significant weight loss. 9 Classical symptoms of CRC include constipation, blood in the stool, decreased caliber, appetite, weight loss, nausea and / or vomiting. 10,11 Pathogenesis CRCs occur as a result of genetic defects and molecular abnormalities associated with the formation and progression of cell growth.…”

Section: Clinical Symptomsmentioning

confidence: 99%

“…Chemotherapy is the first choice of advanced cancer with palliative goals. 9,10 The standard chemotherapy regimen of either adjuvant or palliative is FOLFOX consisting of 5-fluorouracil, leucovorin and oxaliplatin. Targeted therapy has grown rapidly and can be given in a variety of clinical situations, either as a single drug or a combination with other therapeutic modalities.…”

Section: Managementmentioning

confidence: 99%

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The role of transcatheter arterial chemoinfusion (TACI) in unresectable adenocarcinoma colorectal:a case report

Poedjomartono

Pramiadi

2019

JMedScie

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Colorectal cancer (CRC) is the fourth most common cancer in worldwide. In the last 10 years, the mortality rate of CRC decreased by more than 20% and 5-year survival remains approximately 60% due to the rising developments in diagnostic techniques and optimization of surgical, neoadjuvant and palliative therapies. We reported a case of 80-year-old woman with diarrhea, blood in the stool and weight loss for a year. The patient was diagnosed with colonic polyp eight years ago. In double-contrast barium enema (DCBE) showed filling defects in sigmoid with pedunculated form. Optical colonoscopy demonstrated tumor in sigmoid. Computed tomography (CT) abdomen showed circumferential thickening and luminal narrowing of sigmoid colon with stranding of the serosa and mesenteric fat as well as enlarge pericolic nodes without distant metastasis. Based on American Joint Committee on Cancer criteria the stage was T3N1M0. From histopathological diagnosis, the tumor was well differentiated adenocarcinoma. We concluded as unresectable adenocarcinoma colorectal. Patient received transcatheter arterial chemoinfusion (TACI) with oxaliplatin and bevacizunab in three courses every 2 months. After first TACI, symptoms and patient's performance status improved without systemic side effects. Arteriography imaging showed decrease in tumor staining after third TACI. CT evaluation showed a significant decrease of tumor size, without nodal and distant metastasis.In this case, TACI treatment with oxaliplatin and bevacizumab in unresectable adenocarcinoma colorectaldemonstrated improvement of patient's performance status, partial response, decrease stage and symptoms, without systemic side effects. It is proven that TACI treatment may be an effective palliative therapy for unresectable colorectal cancer. Further studies should be performed to verify these findings.We reported a case of a woman with unresectable adenocarcinoma colorectal showed good results after received TACI treatment.

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Section: Clinical Symptomsmentioning

confidence: 99%

Section: Managementmentioning

confidence: 99%

The role of transcatheter arterial chemoinfusion (TACI) in unresectable adenocarcinoma colorectal:a case report

Poedjomartono

Pramiadi

2019

JMedScie

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“…Karakteristik dari gejala klinis KKR dapat berupa timbulnya obstruksi usus, perdarahan (hematochezia, enterorrhagia), perubahan kebiasaan buang air besar, dan efek sistemik seperti penurunan berat badan yang signifikan. 9 Gejala klasik KKR meliputi konstipasi, darah dalam tinja, penurunan kaliber tinja, kehilangan nafsu makan, penurunan berat badan, mual dan atau muntah. 10,11 Patogenesis KKR terjadi sebagai akibat dari defek genetik dan abnormalitas molekular yang berhubungan dengan pembentukan dan progresifitas pertumbuhan sel.…”

Section: Gejala Klinisunclassified

“…Kemoterapi adalah pilihan pertama pada kanker stadium lanjut dengan tujuan paliatif. 9,10 Regimen standar kemoterapi baik adjuvan maupun paliatif yang dianjurkan adalah FOLFOX yang terdiri dari 5-fluorouracil, leucovorin dan oxaliplatin. Targetedtherapy telah berkembang pesat dan dapat diberikan dalam berbagai situasi klinis, baik sebagai obat tunggal maupun kombinasi dengan modalitas terapi lainnya.…”

Section: Penatalaksanaanunclassified

Pencitraan dan Terapi Transcathether Arterial Chemoinfusion pada Unresectable Adenocarcinoma Colorectal

Pramiadi¹,

Poedjomartono²,

Sudarmanta³

2016

J Rad Idn

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Therapeutic itinerary of colorectal cancer patients treated in the state of Rio Grande do Sul

Foletto

Jackisch

Dotto

et al. 2016

Journal of Coloproctology

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Objectives The objective of the study was to evaluate the therapeutic itinerary of patients treated in a specialized center, including its trajectory in seeking treatment and their clinical and epidemiological characteristics. Methods This is a cross-sectional prospective descriptive study; patients with colorectal cancer aged over 18 years and who signed the consent form were included in the analysis. Tumor characteristics, such as staging and tumor features; epidemiological characteristics such as age, gender, profession and itinerary in the form of the number of clinical visits needed to obtain the diagnosis; the main symptoms; and mean time between diagnosis and onset of treatment were evaluated. Results 34% of patients initially sought primary care (first level of care in the public health system) and 50% were diagnosed in secondary care (second level of care in the public health system); the mean number of visits until obtaining a diagnosis was 2.5 times; and 52% of patients received palliative therapy and 40% had a stage IV diagnosis. Conclusions The mean time between the diagnosis and the onset of treatment is in line with the recommendations of the Ministry of Health of Brazil. However, it was found that the patients are unaware of the symptoms of the disease, since the mean time between the onset of symptoms until the decision to visit the doctor was 177 days – which may have been a determining factor for a diagnosis in an advanced stage of disease.

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Clinical and epidemiological evaluation of patients with sporadic colorectal cancer

Cited by 6 publications

References 31 publications

The role of transcatheter arterial chemoinfusion (TACI) in unresectable adenocarcinoma colorectal:a case report

The role of transcatheter arterial chemoinfusion (TACI) in unresectable adenocarcinoma colorectal:a case report

Pencitraan dan Terapi Transcathether Arterial Chemoinfusion pada Unresectable Adenocarcinoma Colorectal

Therapeutic itinerary of colorectal cancer patients treated in the state of Rio Grande do Sul

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