Role of therapeutic plasma exchange as a desensitization therapy in human leukocyte antigen incompatible renal transplant patients: A single-center experience

Therapeutic plasma exchange and HLA desensitization

“…Chowdry et al's protocol highlights the possibility of safely proceeding with transplants in sensitized patients through meticulous desensitization and monitoring of DSA levels. 3 While the study did not offer a direct cost analysis compared to other therapies, it indicates that such a desensitization protocol might be economically feasible, especially in resource-limited settings. Importantly, the principles established in this research may have broader implications, potentially guiding the development of desensitization strategies across various forms of solid organ transplantation.…”

“…In this issue of HTCT, Dr. Chowdry et al 3 have provided valuable comparative insights. Their study evaluated graft survival rates in 106 patients who underwent a desensitization regimen combining therapeutic plasma exchange with intravenous immunoglobulin against a control group that received HLA-compatible transplants.…”