Serial values of hematologic variables and deep venous thrombosis: Red cell distribution width is associated with deep venous thrombosis

Patel, Govind R.; Mahapatra, Manoranjan; Aggarwal, Sadhna; Saxena, Renu

doi:10.1016/j.htct.2022.11.005

Cited by 1 publication

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A high RDW (≥ 14.0%) at admission to ED was significantly associated with the presence of acute DVT, independent of other clinical and laboratory variables, including D-dimer. These findings are consistent with those of previous general population studies or retrospective series, [24][25][26][27][28][29][30] that utilized healthy controls for comparison. RDW was demonstrated to be higher than normal cutoffs in such diverse conditions as cardiac stent thrombosis, 31 heart failure, 32 inflammatory diseases, 33 or acute exacerbation of chronic obstructive pulmonary disease.…”

Section: Discussionsupporting

confidence: 91%

Predictive Value for Increased Red Blood Cell Distribution Width in Unprovoked Acute Venous Thromboembolism at the Emergency Department

Febra,

Spinu,

Ferreira

et al. 2023

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

Acute venous thromboembolism (VTE) is a common worldwide disease admitted to emergency departments (ED), usually presenting as pulmonary embolism or lower limb deep vein thrombosis (DVT). Due to the lack of typical clinical and biomarker diagnostic features of unprovoked VTE, early identification is challenging and has direct consequences on correct treatment delay. Longitudinal, prospective, observational study. Patients admitted to ED with a suspicion of unprovoked acute VTE between October 2020 and January 2021 were included. Clinical and laboratorial variables were compared between VTE positive and negative diagnoses. Red cell distribution width (RDW) cut point was determinate through a receiver operating characteristic analysis. RDW accuracy, sensitivity, and specificity were calculated. Fifty-eight patients were analyzed. And 82.8% of suspected patients with VTE were diagnosed with an acute thrombotic event confirmed by imaging examination. In patients with VTE, RDW at admission in ED was higher than with other diagnosis, respectively, 14.3% (13.2-15.1) and 13.5% (13.0-13.8). Platelet count was the only additional characteristic that revealed difference between the 2 groups (264×109/L for VTE and 209×109/L for non-VTE). Logistic regression models showed good discriminatory values for RDW≥14%, with an area under the curve (AUC) = 0.685 (95% confidence interval, 0.535-0.834). These findings were more pronounced in isolated DVT, with a sensitivity of 76.9%, specificity 100%, and accuracy 85.7%. Our study demonstrated a significant association between an early high RDW and the diagnosis of acute unprovoked DVT. RDW ≥ 14% has an independent predictor of unprovoked VTE in adult patients.

show abstract