Hemograms and serial hemogram-derived ratios in survivors and non-survivors of COVID-19 in Campinas, Brazil

Alagbe, Adekunle Emmanuel; Pedroso, Gisele Audrei; Oliveira, Beatriz Benedetti de; Costa, Everardo Andrade da; Maia, Gisélia Aparecida Freire; Piellusch, Bruna Facanali; Jorge, Susan E.; Costa, Fernando Ferreira; Módena, José Luiz Proença; Schreiber, Angélica Zaninelli; Sonati, María de Fátima; Santos, Magnun Nueldo Nunes

doi:10.1016/j.htct.2022.11.003

Cited by 5 publications

(11 citation statements)

References 23 publications

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“…The study design was prospective in three studies ( 50 , 67 , 68 ), unclear in one ( 66 ), and retrospective in the remaining 36 ( 21 , 36 – 49 , 51 – 65 , 69 – 74 ). The clinical endpoints included mortality in 19 studies ( 36 , 37 , 39 , 41 , 43 , 45 , 48 , 49 , 51 , 52 , 55 , 56 , 58 , 60 , 61 , 65 , 66 , 68 , 73 ), and measures of severe disease as follows: disease severity based on existing guidelines in eight ( 42 , 44 , 63 , 64 , 67 , 70 , 72 , 74 ), transfer to the intensive care unit (ICU) in eight ( 38 , 40 , 45 , 50 , 53 , 62 , 68 , 69 ), invasive mechanical ventilation in two ( 46 , 52 ), disease progression in two ( 57 , 71 ), prolonged hospital stay in one ( 21 ), intubation in one ( 37 ), deep vein thrombosis in one ( 54 ), acute pulmonary embolism in one ( 54 ), and acute limb ischemia in one ( 39 ). All studies reported the SII on hospital admission.…”

Section: Resultsmentioning

confidence: 99%

“…Thirty-nine studies (with 45 patient groups) reported the SII in 19,352 patients (mean age 61 years, 55% males) with a non-severe disease/survivor status and 5,524 patients (mean age 69 years, 60% males) with a severe disease/non-survivor status. Twenty-three studies were conducted in Asia ( 36 , 38 , 40 – 42 , 48 – 51 , 57 , 59 , 62 – 68 , 70 – 74 ), eleven in Europe ( 21 , 39 , 43 , 44 , 47 , 55 , 56 , 58 , 60 , 61 , 69 ), four in America ( 37 , 45 , 46 , 52 ), and one in Africa ( 53 ) ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…The risk of bias was low in 29 studies ( 21 , 36 , 37 , 39 – 41 , 43 – 45 , 47 , 49 , 51 – 53 , 55 – 61 , 64 , 65 , 67 , 69 , 71 – 74 ) and high in the remaining ten ( 38 , 42 , 46 , 48 , 50 , 62 , 63 , 66 , 68 , 70 ) ( Supplementary Table 3 ).…”

Section: Resultsmentioning

confidence: 99%

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Systemic inflammation index, disease severity, and mortality in patients with COVID-19: a systematic review and meta-analysis

Mangoni

Zinellu

2023

Front. Immunol.

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IntroductionAn excessive systemic pro-inflammatory state increases the risk of severe disease and mortality in patients with coronavirus disease 2019 (COVID-19). However, there is uncertainty regarding whether specific biomarkers of inflammation can enhance risk stratification in this group. We conducted a systematic review and meta-analysis to investigate an emerging biomarker of systemic inflammation derived from routine hematological parameters, the systemic inflammation index (SII), in COVID-19 patients with different disease severity and survival status.MethodsA systematic literature search was conducted in PubMed, Web of Science, and Scopus, between the 1st of December 2019 and the 15th of March 2023. Risk of bias and certainty of evidence were assessed using the Joanna Briggs Institute Critical Appraisal Checklist and the Grades of Recommendation, Assessment, Development and Evaluation, respectively (PROSPERO registration number: CRD42023420517).ResultsIn 39 studies, patients with a severe disease or non-survivor status had significantly higher SII values on admission compared to patients with a non-severe disease or survivor status (standard mean difference (SMD)=0.91, 95% CI 0.75 to 1.06, p<0.001; moderate certainty of evidence). The SII was also significantly associated with the risk of severe disease or death in 10 studies reporting odds ratios (1.007, 95% CI 1.001 to 1.014, p=0.032; very low certainty of evidence) and in six studies reporting hazard ratios (1.99, 95% CI 1.01 to 3.92, p=0.047; very low certainty of evidence). Pooled sensitivity, specificity, and area under the curve for severe disease or mortality were 0.71 (95% CI 0.67 to 0.75), 0.71 (95% CI 0.64 to 0.77), and 0.77 (95% CI 0.73 to 0.80), respectively. In meta-regression, significant correlations were observed between the SMD and albumin, lactate dehydrogenase, creatinine, and D-dimer.DiscussionOur systematic review and meta-analysis has shown that the SII on admission is significantly associated with severe disease and mortality in patients with COVID-19. Therefore, this inflammatory biomarker derived from routine haematological parameters can be helpful for early risk stratification in this group.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO, identifier CRD42023420517.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Systemic inflammation index, disease severity, and mortality in patients with COVID-19: a systematic review and meta-analysis

Mangoni

Zinellu

2023

Front. Immunol.

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“… 46 , 47 NLR, MLR, PLR and SII have also been proposed as biomarkers to assess the severity, morbidity, mortality and prognosis of psychiatric and non-psychiatric illnesses. 48 Likewise, it has been reported that NLR and other inflammatory markers decrease after a few weeks compared to acute COVID-19 levels 49 , 50 Although SII, NLR and PLR are suggested to predict the risk of severe COVID-19 and mortality, the inflammatory indices could decrease over time in COVID-19 survivors. 30 , 49 , 51 According to this, individuals with post-COVID condition have shown a relationship between the severity of deterioration and age, where younger patients show impairment in some cognitive domain more frequently than older ones.…”

Section: Discussionmentioning

confidence: 99%

“… 48 Likewise, it has been reported that NLR and other inflammatory markers decrease after a few weeks compared to acute COVID-19 levels 49 , 50 Although SII, NLR and PLR are suggested to predict the risk of severe COVID-19 and mortality, the inflammatory indices could decrease over time in COVID-19 survivors. 30 , 49 , 51 According to this, individuals with post-COVID condition have shown a relationship between the severity of deterioration and age, where younger patients show impairment in some cognitive domain more frequently than older ones. 15 , 52 Surprisingly though, young people were considered to have better expectations, because a younger age induces a better prognosis in dementia and acquired brain damage.…”

Section: Discussionmentioning

confidence: 99%

Aftereffects in Epigenetic Age Related to Cognitive Decline and Inflammatory Markers in Healthcare Personnel with Post-COVID-19: A Cross-Sectional Study

Nolasco-Rosales,

Alonso-García,

Hernández-Martínez

et al. 2023

IJGM

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Purpose Epigenetic age and inflammatory markers have been proposed as indicators of severity and mortality in patients with COVID-19. Furthermore, they have been associated with the occurrence of neurological symptoms, psychiatric manifestations, and cognitive impairment. Therefore, we aimed to explore the possible associations between epigenetic age, neuropsychiatric manifestations and inflammatory markers (neutrophil-lymphocyte ratio [NLR], platelet-lymphocyte ratio [PLR], monocyte-lymphocyte ratio [MLR], and systemic immune-inflammation index [SII]) in healthcare personnel with post-COVID condition. Patients and Methods We applied the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) tests to 51 Mexican healthcare workers with post-COVID-19 condition; we also estimated their epigenetic age using the PhenoAge calculator. Results The participants had a post-COVID condition that lasted a median of 14 months (range: 1–20). High NLR (>1.73) had association with mild cognitive impairment by MMSE (p=0.013). Likewise, high MLR (>0.24) were associated with language domain in MOCA (p=0.046). Low PLR (<103.9) was also related to delayed recall in MOCA (p=0.040). Regarding comorbidities, hypertension was associated with SII (p=0.007), overweight with PLR (p=0.047) and alcoholism was associated with MLR (p=0.043). Interestingly, we observed associations of low PLR (<103.9) and low SII (<1.35) levels with increased duration of post-COVID condition (p=0.027, p=0.031). Likewise, increases in PhenoAge were associated with high levels of SII (OR=1.11, p=0.049), PLR (OR=1.12, p=0.035) and MLR (OR=1.12, p=0.030). Conclusion We observed neurocognitive changes related to inflammatory markers and increases in epigenetic age in healthcare personnel with post-COVID-19 condition. Future research is required to assess mental and physical health in individuals with post-COVID-19 symptoms.

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Pre-Contrast Hemogram-Derived Indices as Predictors for Contrast-Induced Acute Kidney Injury After Percutaneous Coronary Intervention

Alnahal¹,

Mahmoud²,

Amin³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Percutaneous coronary intervention (PCI) may be complicated by contrast-induced acute kidney injury (CI-AKI). The current study aimed to evaluate the pre-contrast hemogram-derived indices as early predictors for CI-AKI after PCI. Methods: A case-control study involved 54 patients who underwent PCI, divided into Group I (27 patients with no CI-AKI), and Group II (27 patients with CI-AKI). After the history taking, examination and routine laboratory investigations, the pre-contrast hemogram-derived indices were calculated; neutrophil / lymphocyte ratio (NLR), platelet / lymphocyte ratio (PLR), neutrophil / platelet ratio (NPR), monocyte / lymphocyte ratio (MLR), eosinophil / lymphocyte ratio (ELR), and systemic immune-inflammation (SII) index (platelet count × (neutrophil count / lymphocyte count). Results: There were significantly higher pre-contrast leucocytes, neutrophils, NLR (p˂0.001) (HS), MLR, PLR, NPR, ELR, and SII in group II than in group I (p˂0.05). The ROC analysis showed a significant predictive value for pre-contrast NLR (92.8% sensitivity & 51.3% specificity), NPR (42.8% & 86.4%), and SII (53.5% & 81.1%), MLR (85.7% & 43.2%), and ELR (50% & 78.3%). The odds ratios (OR) for pre-contrast hemogram-induced indices as predictors for CI-AKI, with confidence interval (CI) 95% were as follows; NLR OR (2.12), CI (0.71-6.31); PLR OR (2.11), CI (0.71-6.26); SII OR (2.96), CI (0.96-9.11); MLR OR (2.89), CI (0.95-8.72); ELR OR (3.4), CI (1.11-10.4); NPR OR (2.5), CI (0.82-7.53); RDW OR (2.12), CI (0.71-6.31). Conclusion: Hemogram-derived indices including pre-contrast SII, NLR, NPR, and MLR may be useful early predictors for CI-AKI after PCI.

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Hemograms and serial hemogram-derived ratios in survivors and non-survivors of COVID-19 in Campinas, Brazil

Cited by 5 publications

References 23 publications

Systemic inflammation index, disease severity, and mortality in patients with COVID-19: a systematic review and meta-analysis

Systemic inflammation index, disease severity, and mortality in patients with COVID-19: a systematic review and meta-analysis

Aftereffects in Epigenetic Age Related to Cognitive Decline and Inflammatory Markers in Healthcare Personnel with Post-COVID-19: A Cross-Sectional Study

Pre-Contrast Hemogram-Derived Indices as Predictors for Contrast-Induced Acute Kidney Injury After Percutaneous Coronary Intervention

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