Evaluation of RET-He values as an early indicator of iron deficiency anemia in pregnant women

Bó, Suzane Dal; Fragoso, Ana Luiza Rodrigues; Farias, Mariela Granero; Hubner, Dariana Pimentel Gomes; Castro, Simone Martins de

doi:10.1016/j.htct.2021.05.006

Cited by 5 publications

(5 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering the risks incurred by iron deficiency anaemia to both the mother and the developing baby, early detection of iron deficiency in pregnant subjects is important. Several studies have shown improvements in the screening of anaemia and the monitoring of effects of iron supplementation in case of IDE during pregnancy, by using parameters indicating the haemoglobin content of mature and immature RBCs 15,19,23,33,34 …”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown that parameters reflecting the haemoglobin content of RBCs and reticulocytes are excellent markers for diagnosing iron deficiency during pregnancy 19,33,34 . Although the reference intervals and diagnostic thresholds are method dependent, corresponding markers on other haematology analyzers have shown similar trends during pregnancy 7,15,20 …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of iron supplementation on microcytic and hypochromic red blood cells during the third trimester of pregnancy

Schoorl

2022

Int J Lab Hematology

View full text Add to dashboard Cite

Introduction: Mild anaemia often occurs in the third trimester of pregnancy. Particularly in the Hb range between 101-110 g/L it is difficult to determine whether the decreased haemoglobin concentration is physiological or pathological and whether supplementation is required.The aim of this study was to gain insight into the added value of measuring the percentages of microcytic RBCs (%MicroR) and hypochromic RBCs (%Hypo-He) for monitoring effects of iron supplementation in case of suspected iron-deficient erythropoiesis (IDE) in the third trimester of pregnancy.Methods: After assessing haematological parameters and zinc protoporphyrin/heme ratio as marker for IDE, subjects were classified into a group with symptoms of IDE (n = 39) or without IDE (n = 106). The subjects with IDE (n = 39) were treated with iron supplementation. After 4 weeks effects of treatment were evaluated.Results: In the group of pregnant women with IDE results of %MicroR and % Hypo-He were increased (p = <.001), compared to the group without haematological symptoms of IDE, whereas RET-He, RBC-He and delta-He were decreased (p = <.001).A significant positive correlation to increased values of %MicroR (r = .75, p = <.001) and %Hypo-He (r = .77, p = <.001) with ZPP was established. However, in the ZPP interval 75-100 μmol/mol heme a slight overlap was demonstrated between subjects with and without symptoms of IDE.After iron supplementation, %Hypo-He decreased (p = .002) while %MicroR remained stable. RET-He, delta-He and RDW-SD increased (p = <.001). Conclusion:The added value of %MicroR and %Hypo-He as a single marker for IDE is poor. However, combined interpretation of %MicroR, %Hypo-He, Ret-He and delta-He has added value in monitoring erythropoiesis during pregnancy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of iron supplementation on microcytic and hypochromic red blood cells during the third trimester of pregnancy

Schoorl

2022

Int J Lab Hematology

View full text Add to dashboard Cite

show abstract

“…La mediana de los valores de Ret-He en la población estudiada fue 32.9 (30.4-36.1) pg, estos resultados son comparables a lo mencionado por Tiwari et al [2] , Bó et al [27] y Torino et al [28] que reportan medianas en controles sanos de 30.78 (20.5-42) en hemoglobina, siendo la mediana del grupo que presentaba anemia la que presentaba valores menores en comparación a los otros 2 grupos, estos resultados concuerdan con Karagülle et al [29] que realizó un estudio mostrando una media del contenido de hemoglobina reticulocitaria (CHr) de 24.95±3.92 en mujeres con anemia con DH (de hemoglobina <12 g/dl y ferritina sérica <20 ng/mL), mientras que Bart et al [30] indica que los niveles de CHr están disminuidos tanto en hombres como mujeres con valores disminuidos de hemoglobina, ferritina y VCM; de la misma forma pero utilizando a la Ret-He Sawadogo et al [31] mostró una disminución de este marcador a medida que disminuyen los índices eritrocitarios. La disminución de la hemoglobina y ferritina reflejarían una diminución del hierro utilizado en la eritropoyesis, disminuyendo los índices eritrocitarios y afectando a la hemoglobina reticulocitaria por lo que podría tener un valor adicional para valorar estado del hierro.…”

Section: Característicaunclassified

Relación del equivalente de hemoglobina reticulocitaria (Ret-He) con diferentes categorías según la concentración de hemoglobina en candidatos a donar sangre

Aro,

Paredes,

Cornejo

et al. 2023

Acta Med Peru

View full text Add to dashboard Cite

Objetivo: determinar la relación entre el Ret-He con diferentes categorías según la concentración de hemoglobina en candidatos a donar sangre. Materiales y Métodos: Se realizó un estudio transversal a partir de la revisión de 227 historias clínicas de candidatos a donar sangre durante el mes de diciembre del 2021 en el Servicio de Banco de Sangre y Hemoterapia del Hospital Cayetano Heredia. Se categorizó en 3 grupos según los niveles de hemoglobina: Grupo 1: ≥12,5 g/dl (mujeres) - ≥13,5 g/dl (varones). Grupo 2: 12 g/dl ≥ mujeres <12.5 g/dl y 13 g/dl ≥ varones<13.5 g/dl. Grupo 3: <12 g/dl (mujeres) - <13 g/dl (varones). Se tomaron datos de hematocrito, hemoglobina, VCM, HCM, CHCM y Ret-He). Para el análisis bivariado se utilizó el análisis de varianza (ANOVA) y se consideró un nivel de significancia del 5%. Resultados: La mediana de Ret-He fue mayor en el grupo 1 que en el grupo 2 (33.5 frente a 32.5; p=0.002) y en el grupo 3 (33.5 frente a 27.8; p<0.001). Se encontró relación estadísticamente significativa entre los grupos estudiados y Ret-He (p<0.001), además de una correlación positiva moderada fuerte entre Ret-He y los índices eritrocitarios. Conclusiones: Se encontró una asociación significativa entre los grupos basados en categorías de hemoglobina y la Ret-He en candidatos a donar sangre.

show abstract

“…The reference intervals for Ret-He have already been determined in different patient populations, ranging from 29.8 pg to 38.2 pg. (27) The proposed 31.2 pg cut-off value of Ret-He was used to differentiate IDA from non-IDA patients. (28) In Thailand, the differences in Ret-He among school-aged children were evaluated, and the Ret-He cut-off ≤27.0 pg was suggested to identify IDA in a thalassemia-prevalent area.…”

Section: Journal Of Southeast Asian Medical Research E0126mentioning

confidence: 99%

Diagnosis of Iron Deficiency Anemia in Thai Female Adolescents Using Reticulocyte Hemoglobin Equivalent

Thimthong

Photia

Traivaree

et al. 2022

J Southeast Asian Med Res

View full text Add to dashboard Cite

Background: Female adolescents aged 10 to 19 years are at remarkable risk of iron deficiency anemia (IDA). Reticulocyte hemoglobin equivalent (Ret-He) is an initial indicator of iron incorporation in red blood cells (RBCs) hemoglobin and reflects the iron functional availability in the RBCs. Objective: This study aimed to assess the diagnostic performance of Ret-He to identify IDA and determine a specific cut-off value for Thai female adolescents. Methods: Blood samples of 191 Thai female adolescents, ages ranging from 12 to 18 years, were included. Patients underwent complete blood count, reticulocyte count, Ret-He, serum iron (SI), total iron-binding capacity (TIBC), and transferrin saturation (TSAT). The correlation of Ret-He with other parameters and the diagnostic performance to identify IDA were evaluated. Results: Among 191 patients, 89 and 102 were defined as IDA and non-IDA groups. Ret-He value in the IDA group was significantly lower than that in the non-IDA group (p<0.001). Strong positive correlations were observed between Ret-He and RBC indices and SI and TSAT (p<0.001). A Ret-He value of ≤27.0 pg could distinguish IDA from non-IDA with a sensitivity of 91.2% and a specificity of 100.0% (area under the curve, AUC of 0.99, 95% CI: 0.98-0.99; p<0.001). Conclusion: This study confirmed that Ret-He is a cost-effective parameter representing an advantage over other traditional iron markers. A specific Ret-He cut-off value of ≤27.0 pg is suitable for distinguishing IDA from non-IDA with excellent diagnostic performance among Thai female adolescents.

show abstract

Evaluation of RET-He values as an early indicator of iron deficiency anemia in pregnant women

Cited by 5 publications

References 21 publications

Effects of iron supplementation on microcytic and hypochromic red blood cells during the third trimester of pregnancy

Effects of iron supplementation on microcytic and hypochromic red blood cells during the third trimester of pregnancy

Relación del equivalente de hemoglobina reticulocitaria (Ret-He) con diferentes categorías según la concentración de hemoglobina en candidatos a donar sangre

Diagnosis of Iron Deficiency Anemia in Thai Female Adolescents Using Reticulocyte Hemoglobin Equivalent

Contact Info

Product

Resources

About