Myeloproliferative Neoplasm Symptom Assessment Form - Total Symptom Score (MPN-SAF TSS) questionnaire: translation, cultural adaptation and validation to Brazilian Portuguese

Translation, Cultural Adaptation, and Validation into Romanian of the Myeloproliferative Neoplasm Symptom Assessment Form—Total Symptom Score (MPN-SAF TSS or MPN-10) Questionnaire

“…Similarly, correlations between RO-MPN-10 items remained moderate or to a lesser extent weak, except for the fatigue-fever, fever-early satiety, fever-inactivity, and itching-weight loss pairs, for which we did not demonstrate any associations, probably because fever was a symptom reported by approximately 6% of the Romanian MPN cohort. Similarly, convergent validity analyses conducted by other scientists have highlighted moderate correlations between fatigue and inactivity (r = 0.51, p < 0.001 versus r = 0.609, p < 0.001 in our study), early satiety (r = 0.51, p < 0.001 versus r = 0.407, p < 0.001 in our study), concentration problems (r = 0.40, p < 0.001 versus r = 0.515, p < 0.001 in our study), or QoL (r = 0.45, p < 0.001 versus r = −0.528, p < 0.001 in our study), as well as between abdominal discomfort and early satiety (r = 0.59, p < 0.001 versus r = 0.676, p < 0.001 in our study), abdominal discomfort and fatigue (r = 0.53, p < 0.001 versus r = 0.466, p < 0.001 in our study), abdominal discomfort and inactivity (r = 0.49, p < 0.001 versus r = 0.465, p < 0.001 in our study), and weight loss and fever (r = 0.42, p < 0.001 versus r = 0.242, p < 0.001 in our study) [7]. Of note, RO-MPN-10 items correlated negatively with QoL scores because we performed a change in the method of evaluating QoL, as suggested by both patients and physicians in the testing phase of the RO-MPN-10.…”

“…Cronbach’s alpha coefficient was used to assess the internal consistency of RO-MPN-10 and values higher than 0.7 were considered as good in line with previous reports [ 7 ]. Convergent validity was evaluated using Pearson/Spearman correlation coefficients, with correlation coefficients higher than or equal to 0.70 indicating strong associations and values higher than or equal to 0.40 but lower than 0.70 indicating moderate associations [ 7 ]. Exploratory factor analysis was performed to assess construct validity and factors with eigenvalues higher than 1 were retained.…”

“…Inter-group means and differences in incidences were compared using ANOVA and chi-squared tests, respectively. Cronbach's alpha coefficient was used to assess the internal consistency of RO-MPN-10 and values higher than 0.7 were considered as good in line with previous reports [7]. Convergent validity was evaluated using Pearson/Spearman correlation coefficients, with correlation coefficients higher than or equal to 0.70 indicating strong associations and values higher than or equal to 0.40 but lower than 0.70 indicating moderate associations [7].…”

“…The MPN-10 has been translated, culturally adapted, and validated to various languages, e.g., French, German, Italian, Spanish, Portuguese, Dutch, Swedish, etc., and has become a useful tool in evaluating patient-reported outcomes (PROs), including in the setting of randomized clinical trials (RCTs) [ 5 , 6 , 7 , 8 , 9 ]. However, a Romanian version of the MPN-10 has not been yet made available, even though there are no other psychometric instruments available in Romanian to measure symptom burden and QoL in patients diagnosed with MPNs.…”

Expression of CD4⁺T Cells in Myeloproliferative Diseases and the Effect of Ruxolitinib Treatment on Prognosis

“…(1) MPN-10 evaluated using MPN Total Symptom Rating Scale (Guaraná, et al 2022) each symptom has a score of 0-10 for assessment, with 0 being no symptoms and 10 being the most severe, with higher scores indicating more severe symptoms. (2) MF scores range from 0 to 3 points (Krečak et al 2021).…”