Reversible cerebral vasoconstriction syndrome after intrathecal cytarabine

Reversible cerebral vasoconstriction syndrome: literature review

“…The largest studies suggest that 50–80% of patients will have a secondary cause for RCVS [ 1 , 10 , 19 , 35 , 41 , 44 ]. The main precipitating factors described are: postpartum state [ 7 , 10 , 13 , 14 , 16 , 25 , 31 , 35 , 39 , 45 – 47 ], drugs with vasoactive properties [ 10 , 12 – 14 , 36 , 39 , 47 , 48 ], such as cocaine, marijuana, and heroin [ 33 , 39 ], catecholamine-secreting tumors [ 35 , 49 – 51 ], autoimmune disorders, such as systemic vasculitis, systemic lupus erythematous, antiphospholipid syndrome [ 13 ], blood transfusions, ginseng [ 5 , 6 ], sexual intercourse, temperature differences (baths too hot or too cold), air travel [ 39 , 48 ], Corona Virus Disease 2019 (COVID-19) infection [ 36 , 52 – 54 ] and medications [ 6 , 29 , 39 , 48 ].…”

“…Reversible Cerebral Vasoconstriction Syndrome, also known as Call-Fleming Syndrome, postpartum angiopathy, migrainous vasospasm, and benign central nervous system angiopathy [10,24,25], is a syndrome characterized by thunderclap headache with severe and transient vasoconstriction of medium-sized vessels of the circle of Willis or extracranial circulation [1,3,12,26]. It commonly manifests with severe headache with or without the presence of ischemia or other acute neurological symptoms [1,2,7,12,13,[19][20][21][27][28][29][30][31][32].…”