Disseminated histoplasmosis diagnosed in a bone marrow sample

Mussá, Naseelah Yunus; Ismail, Sameh H.; Carvalho, Dinah

doi:10.1016/j.htct.2020.10.960

Cited by 2 publications

(4 citation statements)

References 3 publications

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“…Disseminated disease is often seen in immunosuppressed patients. Manifestations can include skin involvement with polymorphic plaques, nodules, and erosions, gastrointestinal involvement with hepatosplenomegaly and colonic ulcerations, and bone marrow suppression [3,4].…”

Section: Discussionmentioning

confidence: 99%

“…Coronavirus disease 2019 (COVID-19) pneumonia-associated fungal infections are well documented with risk factors including ICU prolonged length of stay, neutropenia, hematological malignancies treated with chemotherapy, transplantation, and other immunocompromised states like HIV [1,2]. Disseminated histoplasmosis is often seen in immunosuppressed patients, and can present with multisystem involvement including the lungs, skin, gastrointestinal tract, and bone marrow [3][4][5]. Disseminated histoplasmosis in patients with post-COVID-19 pneumonia is rare and is difficult to diagnose [6].…”

Section: Introductionmentioning

confidence: 99%

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Disseminated Histoplasmosis in an Immunocompetent Patient After COVID-19 Pneumonia

Taylor¹,

Ghodasara²,

Ismail³

et al. 2021

Cureus

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Disseminated histoplasmosis can occur in immunocompromised patients such as in HIV disease and patients with medication-induced immunosuppression. Most of these patients present with fever, weight loss, hepatosplenomegaly, lymphadenopathy, and pancytopenia. There are increasing reports of coronavirus disease 2019 (COVID-19) pneumonia associated with fungal infections including aspergillus and mucormycosis. It is not typical for immunocompetent patients to present with disseminated fungal disease. We herein report a case of a 50-year-old immunocompetent male with a recent recovery from COVID-19 pneumonia who presented with fever and pancytopenia. Chest computed tomography (CT) demonstrated new-onset right upper lobe lung mass, subcarinal lymphadenopathy, and splenomegaly. Mediastinal lymph nodes and bone marrow biopsies were performed, and the patient was diagnosed with disseminated histoplasmosis. The association between COVID-19 pneumonia and fungal infections is increasingly reported. Diagnosis requires a high index of suspicion, especially in immunocompetent patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Disseminated Histoplasmosis in an Immunocompetent Patient After COVID-19 Pneumonia

Taylor¹,

Ghodasara²,

Ismail³

et al. 2021

Cureus

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“…Eight cases of immune reconstitution inflammatory syndrome (IRIS) were diagnosed following antiretroviral treatment [26,29,48,57,59], three patients had haemophagocytic syndrome [27,30,59], and one presented with posterior reversible encephalopathy syndrome (PRESS) [54]. Concomitant opportunistic infections and/or neoplasia were observed in 28.3% of the patients at the time of the diagnosis of histoplasmosis (Table 2 [23,50,51,69], two disseminated cryptococcosis [18,52], and one pulmonary coccidioidomycosis [22]. Kaposi's sarcoma was observed in three patients [19,22,34].…”

Section: People Living With Hiv (Plwh)mentioning

confidence: 99%

“…)[18,19,22,23,25,28,30,[32][33][34]37,39,41,44,45,[49][50][51]53,56,58,59,65,69]: ten patients had candidiasis[19,22,25,41,44,45,51,56,58,59], five Pneumocystis jirovecii pneumonia…”

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confidence: 99%

Histoplasmosis Diagnosed in Europe and Israel: A Case Report and Systematic Review of the Literature from 2005 to 2020

Antinori

Giacomelli

Corbellino

et al. 2021

JoF

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Human histoplasmosis is a mycosis caused by two distinct varieties of a dimorphic fungus: Histoplasma capsulatum var. capsulatum and H. capsulatum var. duboisii. In Europe, it is usually imported by migrants and travellers, although there have been some autochthonous cases, especially in Italy; however, most European physicians are unfamiliar with its clinical and pathological picture, particularly among immunocompromised patients without HIV infection. This systematic review of all the cases of histoplasmosis reported in Europe and Israel between 2005 and 2020 identified 728 cases diagnosed in 17 European countries and Israel described in 133 articles. The vast majority were imported (mainly from Central and South America), but there were also seven autochthonous cases (six in Europe and one in Israel). The patients were prevalently males (60.4%), and their ages ranged from 2 to 86 years. The time between leaving an endemic region and the diagnosis of histoplasmosis varied from a few weeks to more than 40 years. Progressive disseminated histoplasmosis was the most frequent clinical picture among people living with HIV infection (89.5%) or a different immunocompromising condition (57.1%), but it was also recorded in 6.2% of immunocompetent patients. Twenty-eight cases were caused by Histoplasma duboisii. Immunocompromised patients without HIV infection had the worst outcomes, with a mortality rate of 32%.

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Disseminated histoplasmosis diagnosed in a bone marrow sample

Cited by 2 publications

References 3 publications

Disseminated Histoplasmosis in an Immunocompetent Patient After COVID-19 Pneumonia

Disseminated Histoplasmosis in an Immunocompetent Patient After COVID-19 Pneumonia

Histoplasmosis Diagnosed in Europe and Israel: A Case Report and Systematic Review of the Literature from 2005 to 2020

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