Outpatient haploidentical hematopoietic stem cell transplant using post-transplant cyclophosphamide and incidence of hemorrhagic cystitis

Outpatient allogeneic hematopoietic stem-cell transplantation: a review

“…For infection prophylaxis, oral levofloxacin (500 mg/day), acyclovir (400 mg/day), and itraconazole (100 mg/day) or voriconazole (200 mg PO BID) are administered to all patients from the onset of neutropenia until engraftment. 11 Cytomegalovirus (CMV) viral load is determined at day 14 and day 30 post-transplant and thereafter on a clinical basis according to each patient’s risk factors, including the development of GVHD, corticosteroid use, and prior reactivation, among others. No other viruses are monitored routinely.…”

“…In the case of haploidentical grafts with PT-Cy, the occurrence of cytokine release syndrome (CRS), as defined by Lee et al , 44 is a common indication, plus hemorrhagic cystitis; CMV viremia is more frequent in contrast to MSD with calcineurin inhibitor/methotrexate prophylaxis GVHD. 11 …”

“…Other potential complications to have in mind comprise a higher risk of graft failure compared to MSD HSCT, hemorrhagic cystitis, and cytomegalovirus reactivation. 11 , 12 …”

“…They observed durable remissions for hematologic malignancies, particularly for heavily pretreated lymphomas. 10 In our center, we recently reported different outcomes of patients who underwent allo- and haplo-HSCT using MAC or RIC conditioning regimens on an outpatient basis achieving different outcomes of TRM, NRM, and hospitalization requirements 11 , 12 , 35 , 37 ( Table 1 ).…”

“…Other potential complications to have in mind comprise a higher risk of graft failure compared to MSD HSCT, hemorrhagic cystitis, and cytomegalovirus reactivation. 11,12 Nevertheless, outpatient haplo-HSCT is feasible. At least partial outpatient care may be considered in most patients, including ambulatory conditioning with admission at day + 2 or + 3 when CRS appears and an early discharge.…”