Effects of physical exercise for children and adolescents undergoing hematopoietic stem cell transplantation: a systematic review and meta-analysis

Lago, Aline Simone Dias do; Zaffarani, Caroline; Mendonça, Juliana Fernandes Barreto; Moran, Cristiane Aparecida; Costa, Dirceu; Gomes, Évelim Leal de Freitas Dantas

doi:10.1016/j.htct.2020.07.013

Cited by 8 publications

(11 citation statements)

References 16 publications

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“…In our sample the mobility patterns and EP adherence increased in the final phase of hospitalisation, when children/adolescents felt better and were able to leave their rooms. The lower adherence to RCI from the EG subjects could be related to the fact that they found it easier to get involved in the supervised part of the EP programme, as reported by some reviews (Lago et al, 2020; Rossi et al, 2016) that highlight how supervised EP have more benefits than unsupervised ones.…”

Section: Discussionmentioning

confidence: 96%

Rehabilitation in children and adolescents undergoing stem cell transplantation: A pilot study focused on motor performance

Rossi

Zucchetti

Esposito

et al. 2022

European J Cancer Care

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Objectives The aim of this pilot trial is evaluating the preliminary effectiveness of two in‐hospital interventions in the maintenance of motor performance in children/adolescents undergoing hematopoietic stem cell transplantation (HSCT). Secondary objectives investigated the interventions' feasibility, impact on fatigue and to what degree the subjects' maintained their ankle dorsiflexion range of movement (ROM), functional mobility, muscle strength and flexibility. Methods This trial included 5‐ to 18‐year‐old participants, affected by oncological and non‐oncological diseases during hospitalisation for autologous/allogenic HSCT. The subjects were assigned to an exercise group (EG), or a counselling group based on a cluster model based on inpatient timeframe. The EG subjects performed strengthening, stretching and aerobic exercises for 30 min/5 days a week. Both groups followed rehabilitation counselling indications (RCI), 7 days a week. Results Forty‐nine participants were enrolled (median age = 12.9 years) (EG n = 36). In both groups the participants maintained their baseline motor performance and ankle ROM, and the children/adolescents and parents reduced their levels of fatigue. However, the interventions were not effective in maintaining strength. Conclusion In maintaining the subjects' motor performance, the RCI results are significant because they pave the way for the application in clinical practice contexts where there are poor rehabilitation resources. Clinical Trials registration NCT03842735.

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Section: Discussionmentioning

confidence: 96%

Rehabilitation in children and adolescents undergoing stem cell transplantation: A pilot study focused on motor performance

Rossi

Zucchetti

Esposito

et al. 2022

European J Cancer Care

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“…While there is a growing number of publications describing positive effects of exercise modalities in adult HSCT patients, [5][6][7][8][9][10] few publications describe the impact of exercise training on pediatric HSCT patients. 11 The results of these studies are, however, promising. San Juan et al showed beneficial effects on functional performance, muscle strength, and QoL scores in eight children (aged 8-16 years) undergoing a supervised exercise program that included resistance and aerobic exercises for 3 weeks after HSCT.…”

Section: Introductionmentioning

confidence: 97%

“…A potentially important intervention—one that can impact both physical and psychological consequences of HSCT—focuses on exercise programs. While there is a growing number of publications describing positive effects of exercise modalities in adult HSCT patients, 5–10 few publications describe the impact of exercise training on pediatric HSCT patients 11 . The results of these studies are, however, promising.…”

Section: Introductionmentioning

confidence: 99%

Effects of an exercise program during pediatric stem cell transplantation: A randomized controlled trial

Smith

Farhat

Fern‐Buneo

et al. 2022

Pediatric Blood & Cancer

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Background: During pediatric hematopoietic stem cell transplant (HSCT), there is significant reduction in physical activity, leading to loss of strength and function, along with decline in quality of life (QoL). This study evaluates the effects of a supervised exercise program on functional ability, mobility, strength, and QoL during and following pediatric HSCT.Methods: Patients ages 4-21 years presenting for HSCT were randomized to either an intervention group, who underwent exercise routines three times weekly and once weekly on discharge for 6 weeks supervised by a physical therapist, or the control group, which was treated per standard of care. Forty subjects were recruited for the study, 20 in each arm. Physical therapy and QoL assessments were conducted at three time points: pre-HSCT (baseline), on the day of hospital discharge, and 6 weeks after discharge.Results: Exercise capacity and endurance using Six-Minute Walk test (p = .023) and strength using manual muscle testing (p = .005) were improved in the exercise group, compared to the control group. There was evidence that some QoL outcomes (measured using the Patient Reported Outcomes Measurement Information System) were improved 6 weeks post discharge, with observed decreases in anxiety (p = .0009) and fatigue (p = .037). Conclusion:Supervised exercise program during pediatric HSCT has positive effects on endurance, functional mobility, and muscle strength, and may also result in improvements in some aspects of QoL. This trial was registered at www.clinicaltrials.gov as NCT04663503.

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“…A recent systematic review and meta-analysis showed that years after treatment had ended, childhood HSCT survivors have an impaired CRF compared to non-HSCT controls (with a similar, albeit less clear trend for muscle strength and physical performance) [ 97 ]. There is also meta-analytical evidence that exercise is a safe strategy that can potentially preserve functional mobility, CRF and HRQoL in children and adolescents undergoing HSCT [ 98 , 99 ]. Therefore, there seems to be no reason to avoid physical exercise during childhood HSCT [ 100 ].…”

Section: Exercise During/after Childhood Hematopoietic Stem Cell Transplantationmentioning

confidence: 99%

Exercise and Childhood Cancer—A Historical Review

Morales

Velázquez-Díaz

Castillo‐García³

et al. 2021

Cancers

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Childhood cancer survivors are at risk of developing important adverse effects, many of which persist for years after the end of treatment. The implementation of interventions aiming at attenuating tumor/treatment-associated adverse effects is therefore a major issue in pediatric oncology, and there is growing evidence that physical exercise could help in this regard. The present review aims to summarize the main milestones achieved in pediatric exercise oncology. For this purpose, we conducted a systematic review of relevant studies written in English in the electronic database PubMed (from inception to 14 August 2021). This review traces the field of pediatric exercise oncology throughout recent history based on three fundamental pillars: (i) exercise during childhood cancer treatment; (ii) exercise during/after hematopoietic stem cell transplantation; and (iii) exercise after childhood cancer treatment. Accumulating evidence––although still preliminary in many cases––supports the safety and potential benefits of regular exercise (with no major contraindications in general) in the childhood cancer continuum, even during the most aggressive phases of treatment. Exercise can indeed represent an effective coadjuvant therapy for attenuating cancer-related adverse effects.

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Effects of physical exercise for children and adolescents undergoing hematopoietic stem cell transplantation: a systematic review and meta-analysis

Cited by 8 publications

References 16 publications

Rehabilitation in children and adolescents undergoing stem cell transplantation: A pilot study focused on motor performance

Rehabilitation in children and adolescents undergoing stem cell transplantation: A pilot study focused on motor performance

Effects of an exercise program during pediatric stem cell transplantation: A randomized controlled trial

Exercise and Childhood Cancer—A Historical Review

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