The effect and correlation of smoking with platelet indices, neutrophil lymphocyte ratio and platelet lymphocyte ratio

Pujani, Mukta; Chauhan, Varsha; Singh, Kanika; Rastogi, Samarth; Agarwal, Charu; Gera, Kamal

doi:10.1016/j.htct.2020.07.006

Cited by 13 publications

(12 citation statements)

References 10 publications

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“…From another point of the view, it is also shown that stress-related hormones such as catecholamine and cortisol are related to an increase in NLR (32). Considering that nocturnal overactivity of the hypothalamic-pituitary-adrenal system is linked to RLS/WED and related disturbed sleep, it might be a factor that contributes to increased NLR in pregnant women with RLS/WED, but further studies are needed for this conclusion (33), Also, an increase in NLR and PLR was associated with smoking (34), which was suggested to be used as a systemic infl ammatory biomarker to indicate the deleterious effects of smoking. In this term, the mechanisms by which smoking increases the risk of RLS/WED during pregnancy may be explained at least in part by infl ammation.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil‑to‑lymphocyte ratio as a marker of inflammation in restless legs syndrome during pregnancy

Karadeniz¹,

Ser²,

Nalbantoğlu³

et al. 2022

BLL

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PURPOSE: The pregnancy is accepted as an independent risk factor for restless legs syndrome/Willis-Ekbom disease (RLS/WED). The neutrophil-to-lymphocyte ratio (NLR) was recently reported in the pathophysiology of RLS/WED. In this report, we investigated the relationship between the presence of RLS/ WED and the levels of NLR in pregnancy. METHODS: We included 268 pregnant women attending routine prenatal visits; 148 women had RLS/WED, and 120 women without RLS/WED were the control group. A pre-formed questionnaire was administered to all participants regarding demographic characteristics, habitual behaviors, detailed medical history and questions about RLS/WED including disease duration, severity, and family history. Laboratory investigations were performed in all participants regarding the complete blood count, NLR, fasting blood glucose, blood urea nitrogen, creatinine, ferritin, and total iron binding capacity. RESULTS: NLR was signifi cantly higher in pregnant women with RLS/WED as compared to those without it (3.9±0.9 versus 3.5± 1.1, p = 0.039). Smoking was also signifi cantly more common in pregnant women with RLS/WED (p=0.022). NLR signifi cantly increased as the gestational period progressed, even after the adjustments for age, BMI, and smoking (p = 0.035). Higher NLR in pregnant women with RLS/WED was especially prominent in the 3rd trimester, although the difference was not signifi cant. CONCLUSION: These results may suggest that an increased infl ammation demonstrated by the increased NLR, may, in part, play a role in higher prevalence of RLS/WED in pregnancy, especially in late gestational weeks (Tab. 2, Fig. 1, Ref. 34).

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Section: Discussionmentioning

confidence: 99%

Neutrophil‑to‑lymphocyte ratio as a marker of inflammation in restless legs syndrome during pregnancy

Karadeniz¹,

Ser²,

Nalbantoğlu³

et al. 2022

BLL

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“…the same result was reported by Mukta Pujani et al There was no significant difference in the NLR among the smokers and non-smokers (2.61 ± 1.99), (2.48 ± 2.30) respectively. [17].…”

Section: Discussionmentioning

confidence: 99%

Role of cholesterol, lipoproteins, and neutrophilic-lymphocytic ratio in patients with pneumonia

El-Aaty

Elmahallawy

Elmaksoud³

et al. 2022

Egypt J Bronchol

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Background Lipids play numerous functions in lung biology and pathophysiology of infection, in addition to their role in lipid transport, lipoproteins share in innate immunity that is the most important way for the host to defend against microbes. The NLR (neutrophil-lymphocytic ratio) is a good indicator of systemic inflammation and infection. Objective To evaluate the role of cholesterol, lipoproteins, and neutrophilic-lymphocytic ratio in the assessment of patients with pneumonia. Patients and methods This prospective case–control study included 52 subjects; they were categorized into 2 groups. Group A included 42 patients with pneumonia admitted to the Chest Department,Menoufia University, and group B included 10 healthy people during the period from May 2019 to December 2019. History taking, clinical examination, laboratory investigation in the form of CBC and lipid profile, and radiological investigation in the form of CXR and CT chest if needed were done to all subjects of the study. Results The mean cholesterol level in group A was 149.76 ± 42.79 which was statistically significantly lower as compared with group B (165.90 ± 45.50) (p = 0.039). The mean HDL level in group A was 43.16 ± 6.32 which was statistically significantly lower as compared with group B (50.51 ± 9.60) (p = 0.026). No statistically significant difference was found in the triglyceride level, LDL level and VLDL between the subjects in the two studied groups (p = 0.479, 0.792, and 0.606), respectively, but all levels were still within normal levels. Mean NLR in group A was 7.04 ± 7.98 which was statistically significantly higher as compared with group B (3.04 ± 1.6) (p = 0.004). Roc curve of neutrophil–lymphocyte ratio shows that the cutoff point is 1.94 and the N/L ratio had area under curve of 78% with 79.6% sensitivity and 67.8% specificity. Conclusion Serum cholesterol and high-density lipoprotein levels significantly decreased in patients with pneumonia when compared to the control group but were still within normal range. Lipid profile is affected by different variables like smoking index, body mass index, and sex. The neutrophil–lymphocyte at cutoff point is 1.94, and N/L ratio had area under curve of 78% with 79.6% sensitivity and 67.8% specificity. Trial registration TCTR, TCTR20220524001. Registered on 24 May 2022, retrospectively registered.

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“…These results indicated that the preoperative serum of the patients who developed sFS after RCR was sufficient to induce shoulder capsule fibrosis, which was related to its effect on macrophage polarization and fibroblast activation. NLR can be influenced by various factors, such as smoking, gender, aging et al, 44,45 therefore is hard to figure out the exact reason behind its variation among population. Instead, we directly investigated the effect of serum on shoulder capsule in a mouse model.…”

Section: Discussionmentioning

confidence: 99%

“…NLR can be influenced by various factors, such as smoking, gender, aging et al, 44 , 45 therefore is hard to figure out the exact reason behind its variation among population. Instead, we directly investigated the effect of serum on shoulder capsule in a mouse model.…”

Section: Discussionmentioning

confidence: 99%

The Serum from Patients with Secondary Frozen Shoulder Following Rotator Cuff Repair Induces Shoulder Capsule Fibrosis and Promotes Macrophage Polarization and Fibroblast Activation

Sun

Lin

Luo

et al. 2021

JIR

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Disorders with systematic inflammation were prognostic for secondary frozen shoulder (sFS) following rotator cuff repair (RCR); however, how systematic inflammation affects sFS remains unclear. The aim of this study was to observe the effect of pre-operative serum from patients with sFS and the serum from those without on shoulder capsule in mice, and on macrophages and fibroblasts in vitro. Methods: Serum samples of a consecutive cohort of patients for RCR were collected preoperatively. Three months after RCR, patients who developed sFS (Group S) were identified. Serum samples from gender-and age-matched controls without sFS (group NS) were also picked out. Firstly, the effect of serum on shoulder capsule fibrosis was observed histologically and biomechanically in a mouse model of RCR. Secondly, the roles of the serum on macrophage polarization and fibroblast activation were investigated, and the potentially involved signaling pathways were identified. Finally, inflammation and fibrosis-related cytokines in serum were quantified. Results: In our cohort, all patients had free pre-operative shoulder range of motion. Seven patients developed sFS at 3 months after surgery. Seven matched patients without sFS were selected as control. The inter-group difference of basic characteristics was not significant. Compared to the serum of group NS, the serum of group S significantly induced hypercellularity, capsular thickening, and range of motion deficiency in mice shoulders after RCR. Compared to the serum of group NS, samples of group S significantly promoted M2 polarization of THP-1 human macrophages and the activation of human capsule-derived fibroblasts. Meanwhile, Smad3 and p-Smad3 in macrophages and fibroblasts were significantly up-regulated. On the other hand, levels of inflammation and fibrosis-related cytokines were not significantly different between serum in group S and group NS. Conclusion: Although all patients in this cohort had free range of motion pre-operatively, the pre-operative serum from patients with sFS at 3 months after RCR could act as a trigger of shoulder capsule fibrosis post-operatively. This effect may be related to its promotion on macrophage polarization to M2 phenotype and fibroblast activation.

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The effect and correlation of smoking with platelet indices, neutrophil lymphocyte ratio and platelet lymphocyte ratio

Cited by 13 publications

References 10 publications

Neutrophil‑to‑lymphocyte ratio as a marker of inflammation in restless legs syndrome during pregnancy

Neutrophil‑to‑lymphocyte ratio as a marker of inflammation in restless legs syndrome during pregnancy

Role of cholesterol, lipoproteins, and neutrophilic-lymphocytic ratio in patients with pneumonia

The Serum from Patients with Secondary Frozen Shoulder Following Rotator Cuff Repair Induces Shoulder Capsule Fibrosis and Promotes Macrophage Polarization and Fibroblast Activation

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