Pregnancy in a 31-year-old woman with chronic lymphocytic leukemia: a case report and review of the literature

Murray, Nigel P; Orrego, Shenda; López, Marco Antonio; Minzer, Simona

doi:10.1016/j.htct.2020.01.008

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…Reviewing the literature on the topic, it is mainly based on anecdotal case reports [3,[5][6][7][8][9]. Few of them also report details on therapy given during pregnancy such as leukapheresis [6] and chemotherapy [5].…”

Section: Introductionmentioning

confidence: 99%

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Pregnancy Course of 10 Women Diagnosed with Chronic Lymphocytic Leukemia

Tadmor¹,

Melamed²,

Alapi³

et al. 2023

Acta Haematol

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Pregnancies following diagnosis of chronic lymphocytic leukemia (CLL) are rare events, mainly because the disease is typically diagnosed in the elderly. Literature on the topic is based only on case reports, and limited data are available on the influence of pregnancy on CLL course. In this retrospective study, we aimed to summarize the clinical and laboratory course of 10 women with CLL who became pregnant. None of the patients had significant changes in blood count during or after pregnancy or had complications such as infection, autoimmune phenomenon, or preeclampsia. Four out of 10 pregnancies were terminated with an early miscarriage. Following labor, 1 patient started anti-CLL treatment due to preexisting anemia, but none of the women required therapy during CLL progression during the first 2 years of follow-up. We conclude that based on our serial, pregnancy does not negatively impact on CLL course.

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Section: Introductionmentioning

confidence: 99%

“…CLL is the most frequent leukemia in the Western world, yet it is a disease of the elderly with a median age at diagnosis of 72 years old and is more frequent in males [1, 2]. Only 2% are women below 40 years old [3, 4], and this explains the rarity of pregnancy cases.…”

Section: Introductionmentioning

confidence: 99%

Pregnancy Course of 10 Women Diagnosed with Chronic Lymphocytic Leukemia

Tadmor¹,

Melamed²,

Alapi³

et al. 2023

Acta Haematol

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“…The most common reason of induced abortion among pregnancy induced malignancies is hematologic disease (21%) [3]. Although it is the most common adult leukemia, B-cell chronic lymphocytic leukemia (CLL) has been reported in pregnancy in less than 10 cases [4][5][6][7][8][9][10][11][12][13]. The median age of CLL is 70 years and approximately 2% of patients are aged <45 years [14,15].…”

Section: Introductionmentioning

confidence: 99%

Chronic lymphocytic leukemia diagnosed during pregnancy - case report and review of literature

2022

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Introduction. B-cell chronic lymphocytic leukemia (CLL) can be easily overlooked in pregnancy, particularly in cases with inadequate antenatal care. We report a case of pregnant woman diagnosed with CLL and evaluate this patient to cases in the literature. Case report. An asymptomatic 35-year-old woman presented with slightly elevated absolute lymphocyte count at antenatal monitoring in her second pregnancy. Further hematological investigations disclosed CLL with monoallelic deletion of chromosome 13q14. She was monitored during throughout the pregnancy, being asymptomatic and without treatment, and delivered a healthy child at term with no complications. After almost four years of follow up patient is without any signs of disease progression and her absolute lymphocyte counts remained on predelivery levels. This is the first published case of CLL diagnosed during pregnancy in Serbia. Rare similar cases published so far have been discussed, especially in terms of disease course, long-term prognosis and available therapeutic modalities. Conclusion. Due to the fact that nowadays many women are delaying childbearing in middle age it can be expected that cancer diagnose could be more often found in pregnant women in the future. In a view of the complex nature of such condition, a multidisciplinary approach for diagnosing and treating of pregnant women is highly recommended.

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Pregnancy in a 31-year-old woman with chronic lymphocytic leukemia: a case report and review of the literature

Cited by 2 publications

References 6 publications

Pregnancy Course of 10 Women Diagnosed with Chronic Lymphocytic Leukemia

Pregnancy Course of 10 Women Diagnosed with Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia diagnosed during pregnancy - case report and review of literature

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