Association of coagulation profile with microvascular complications and glycemic control in type 2 diabetes mellitus – a study at a tertiary care center in Delhi

Agarwal, Charu; Bansal, Kashish; Pujani, Mukta; Singh, Kanika; Chauhan, Varsha; Rana, Deepshikha; Lukhmana, Shveta

doi:10.1016/j.htct.2018.05.002

Cited by 15 publications

(14 citation statements)

References 9 publications

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“…The variation in study variables especially age could have led to the differences in activated partial thromboplastin time, prothrombin time and international normalized ratio in this study as compared to others. A study done by Agarwal et al, (11) revealed shortened activated partial thromboplastin time and prothrombin time and hence being inconsistent with findings of this study, the reason could be attributed to age of the participants as participants were aged 35 -70 years while participants in this current study were younger aged 18 -60 years. In addition, the sample size was smaller, 60 diabetics and 30 controls as compared to this study could have resulted to the disparities between this studies, and the race (Indian race vs African race) as well.…”

Section: Discussioncontrasting

confidence: 94%

Evaluation of Prothrombin time and Activated Partial Thromboplastin Time Tests in Diabetes Mellitus Patients at Meru Teaching and Referral Hospital

Wambua¹

2020

jmscr

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Introduction: Diabetes mellitus is a chronic and a progressive disease. The risk of at herothrombotic complication is increased in diabetics. Research has shown a diverse of Diabetes mellitus related abnormalities especially in haemostasis and thrombosis. The main objective of this study was to investigate the Prothrombin time and Activated partial thromboplastin time in Diabetes mellitus patients. Methodology: Descriptive analytical cross-sectional study was employed to recruit 371 participants. Venous blood was collected (4.5 mls) in 3.2% trisodium citrate (0.5 mls) for prothrombin time and activated partial thromboplastin time testing. It was analyzed using coagulation analyzer (Start 4). Capillary blood was used for glucose estimation by glucose oxidase method. Results: There was low degree of correlation between prothrombin time, international normalized ratio and activated partial thromboplastin time of diabetics as compared to the controls (R=4%, p=0.215, R=4%, P=0.221 and R=4%, P=0.445 respectively). There was statistical significant in activated partial thromboplastin time in relation to age (p=0.005) with no statistical significant in prothrombin time (0.839) and international normalized ratio (p=0.880). Conclusion: Prothrombin time and international normalized ratio were not significantly affected by the diabetic state of the study subjects. Activated partial thromboplastin time had a significant difference in age group means revealing hypercoagulable state. Preventive measures should be undertaken in these age groups to ensure complications associated with hypercoagulable state do not occur.

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Section: Discussioncontrasting

confidence: 94%

Evaluation of Prothrombin time and Activated Partial Thromboplastin Time Tests in Diabetes Mellitus Patients at Meru Teaching and Referral Hospital

Wambua¹

2020

jmscr

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“…Mwambungu et al, [31] reported low significant APTT in type 2 diabetes because T2DM patients are more prone to hyper coagulable state with increased thrombotic risk of cardiovascular events. This is in agreement with the work of Ankalayya et al, [32] who reported shortened APTT in type 2 diabetes with thrombotic risks. Ambelu et al, [33] reported low APTT level of 85% in untreated and 2.5% in treated type 2 diabetes.…”

Section: Discussionsupporting

confidence: 93%

“…This agrees with the findings of Pan et al, [34] that reported shortened APTT in T 2 D was associated with diabetic complication such as nephropathy. This is consistent with the study of Agarwal et al, [32] that reported that low APTT occurred with or without diabetic complications. In contrary to this study, Alao et al, [35] reported significant prolonged due to thrombo haemorrhage shift in haemostasis balance.…”

Section: Discussionsupporting

confidence: 93%

Studies on Haemostatic Parameters of Type 2 Diabetics in Owerri, Imo State

C¹,

U²,

C³

et al. 2019

SJMPS

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Type 2 diabetes mellitus is a chronic metabolic disorder which has emerged as a health challenge globally due to its insidious on set, late recognition and complications. The present study was aimed at evaluation of haemostatic parameters in Owerri. Cross Sectional Studies was conducted at Federal Medical Center and Imo State specialist Hospital, Owerri. A total of three hundred subjects which include each one hundred and fifty type 2 diabetics and apparently control subjects between the ages forty and sixty nine years were recruited. Ten millimeters of venous blood as aseptically collected from thesubjects. Platelet count and coagulation assay were used for determination of these parameters .The data was analyzed using statistical package for social science 20.0. Test with a probability value of P<0.05 was considered statistically significant. Results from haemostatic parameters showed higher statistically significant value (P = 0.001) in platelet count (226.68 ± 19.40 vs 205 .86 ± 13.33x10 9 /l), and fibrinogen (370.19) ± 21.55 v 2.63.56 ± 32.31mg/dl) when type 2 diabetics was compared with control subjects. Inversely, there was statistically significantly lower values; (P = 0.031) in prothrombin time (13.47 ± 0.96 v 14.06 ± 0.96s) and (P = 0.001) in activated partial thrombopalstin time (34,39 ± 2.17 v 37.25 ± 1.82).There was statistically significant progressive increase in activated partial thromboplastin time (

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“… 21 Compared to patients without complications with T2DM, patients with microvascular complications such as retinopathy, nephropathy, or neuropathy with T2DM had lower PT and APTT levels and higher FIB levels. 22 …”

Section: Discussionmentioning

confidence: 99%

The Correlation Between Estimated Glucose Disposal Rate and Coagulation Indexes in Type 2 Diabetes Mellitus

Li¹,

Qi²,

Jia³

et al. 2022

DMSO

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Purpose To study the correlation between estimated glucose disposition rate (eGDR) and coagulation parameters in type 2 diabetes patients (T2DM). Materials and Methods A total of 948 patients suffering from T2DM were enrolled for this research. Various blood coagulation parameters including prothrombin time (PT), activated partial thromboplastin time (APTT), and fibrinogen (FIB) were assessed. Body mass index (BMI), hypertension, and the levels of glycated hemoglobin (HbA1c) were used to calculate the patients’ eGDRs. All patients were sorted into two groups: those with high eGDRs (eGDR≥7.5) and those with low eGDRs (eGDR<7.5). The patients were then separated into groups of men and women. The connection between eGDR and coagulation indexes was examined using Spearman correlation, Pearson correlation, and multiple linear regression analysis. Results In comparison to the high-eGDR group, reduced PT and APTT levels with increased FIB levels were observed in the low-eGDR group ( P =0.006, P <0.001, and P = 0.035, respectively). The eGDR showed a positive relation with APTT (r = 0.142, P < 0.001), a negative relation with FIB (r = −0.082, P = 0.012), and no correlation with PT (r =0.064, P =0.050) in the all patients. As well as, the eGDR demonstrated a positive relation with APTT (r = 0.173, P < 0.001), a negative relation with FIB (r = −0.093, P = 0.03), and no relation with PT (r = 0.045, P = 0.300) in the male subgroups. Additionally, this correlation persisted following the adjustment of other factors in multilinear regression analysis. However, the female subgroup demonstrated no correlation among eGDR and PT, APTT or FIB (r = 0.086, P = 0.083, r = 0.097, P = 0.05;r = −0.058, P = 0.240, respectively). Conclusion Our study is the first to prove that eGDR demonstrates a correlation with coagulation indexes in T2DM patients. And, this correlation is gender-specific.

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Association of coagulation profile with microvascular complications and glycemic control in type 2 diabetes mellitus – a study at a tertiary care center in Delhi

Cited by 15 publications

References 9 publications

Evaluation of Prothrombin time and Activated Partial Thromboplastin Time Tests in Diabetes Mellitus Patients at Meru Teaching and Referral Hospital

Evaluation of Prothrombin time and Activated Partial Thromboplastin Time Tests in Diabetes Mellitus Patients at Meru Teaching and Referral Hospital

Studies on Haemostatic Parameters of Type 2 Diabetics in Owerri, Imo State

The Correlation Between Estimated Glucose Disposal Rate and Coagulation Indexes in Type 2 Diabetes Mellitus

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