Abstract:ObjectivesTo determine the frequency of folic acid deficiency in consecutive serum folate determinations and to determine whether there was a significant decrease in serum folate deficiency after folate was added to wheat flour.MethodsA retrospective descriptive observational study was performed of consecutive folate measurements at the Hospital Privado Universitario, Cordoba, Argentina.ResultsTwo cohorts were analyzed: 1197 folate measurements between 2001 and 2008 (before supplementation) and 3335 folate mea… Show more
“…The prevalence of folate deficiency (<3.0 ng/mL) was reported to be low at 0.056% to 1.73% [28,29] in Western countries since folic acid fortification began in 1998. In a population of individuals aged 50 years or more, 2.2–2.3% had a deficiency in folic acid (<3.0 ng/mL) [28].…”
Section: Discussionmentioning
confidence: 99%
“…The prevalence of folate deficiency (<3.0 ng/mL) was reported to be low at 0.056% to 1.73% [28,29] in Western countries since folic acid fortification began in 1998. In a population of individuals aged 50 years or more, 2.2–2.3% had a deficiency in folic acid (<3.0 ng/mL) [28]. In healthy Korean adults, about 13.3% of men and 3.2% of women showed a folate deficiency (<3.0 ng/mL) [30] but there has been a lack of research in elderly populations.…”
Objective This study aimed to examine the association between normal-but-low folate levels and cognitive function in the elderly population using a prospective cohort study. Methods We analyzed 3,910 participants whose serum folate levels were within the normal reference range (1.5-16.9 ng/mL) at baseline evaluation in the population-based prospective cohort study named the "Korean Longitudinal Study on Cognitive Aging and Dementia. " The association between baseline folate quartile categories and baseline cognitive disorders [mild cognitive impairment (MCI) or dementia] was examined using binary logistic regression analysis adjusting for confounding variables. The risks of incident MCI and dementia associated with the decline of serum folate level during a 4-year follow-up period were examined using multinomial logistic regression analysis. Results The lowest quartile group of serum folate (≥1.5, ≤5.9 ng/mL) showed a higher risk of cognitive disorders than did the highest quartile group at baseline evaluation (odds ratio 1.314, p=0.012). Over the 4 years of follow-up, the risk of incident dementia was 2.364 times higher among subjects whose serum folate levels declined from the 2nd-4th quartile group to the 1st quartile than among those for whom it did not (p=0.031).
“…The prevalence of folate deficiency (<3.0 ng/mL) was reported to be low at 0.056% to 1.73% [28,29] in Western countries since folic acid fortification began in 1998. In a population of individuals aged 50 years or more, 2.2–2.3% had a deficiency in folic acid (<3.0 ng/mL) [28].…”
Section: Discussionmentioning
confidence: 99%
“…The prevalence of folate deficiency (<3.0 ng/mL) was reported to be low at 0.056% to 1.73% [28,29] in Western countries since folic acid fortification began in 1998. In a population of individuals aged 50 years or more, 2.2–2.3% had a deficiency in folic acid (<3.0 ng/mL) [28]. In healthy Korean adults, about 13.3% of men and 3.2% of women showed a folate deficiency (<3.0 ng/mL) [30] but there has been a lack of research in elderly populations.…”
Objective This study aimed to examine the association between normal-but-low folate levels and cognitive function in the elderly population using a prospective cohort study. Methods We analyzed 3,910 participants whose serum folate levels were within the normal reference range (1.5-16.9 ng/mL) at baseline evaluation in the population-based prospective cohort study named the "Korean Longitudinal Study on Cognitive Aging and Dementia. " The association between baseline folate quartile categories and baseline cognitive disorders [mild cognitive impairment (MCI) or dementia] was examined using binary logistic regression analysis adjusting for confounding variables. The risks of incident MCI and dementia associated with the decline of serum folate level during a 4-year follow-up period were examined using multinomial logistic regression analysis. Results The lowest quartile group of serum folate (≥1.5, ≤5.9 ng/mL) showed a higher risk of cognitive disorders than did the highest quartile group at baseline evaluation (odds ratio 1.314, p=0.012). Over the 4 years of follow-up, the risk of incident dementia was 2.364 times higher among subjects whose serum folate levels declined from the 2nd-4th quartile group to the 1st quartile than among those for whom it did not (p=0.031).
“…In the current issue of Hematology, Transfusion and Cell Therapy , Godoy and Tabares 3 provide interesting retrospective data on the epidemiology of FD in a tertiary care hospital in Argentina, before and after folic acid wheat flour supplementation was implemented. Their main findings support that FD, as defined by a serum folate lower than 3 ng/mL (6.7 nmol/L), became a very rare condition after FFF, with a yearly incidence of 1.7%.…”
mentioning
confidence: 99%
“… Figure 1 Prevalence of FD in different populations, as determined by serum folate levels, before and after mandatory FFF programs around the world. Data represent the studies with the largest populations in each country (Argentina, 3 Australia, 11 Brazil, 12 , 13 Cameroon, 14 Canada, 15 Chile, 16 Iran, 17 Tanzania, 10 and the United States of America 18 ). …”
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