Pyoderma gangrenosum and erythema elevatum diutinum associated with a high-risk myelodysplastic syndrome: case report

Vide, Júlia; Brás, G.; Guimarães, José E.; Mota, Alberto

doi:10.1016/j.htct.2017.11.005

Cited by 3 publications

(3 citation statements)

References 10 publications

(13 reference statements)

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“…As described in our case, Caucanas et al reported the development of three different entities of ND in one patient (EED, PG, and SS) [5]. PG can be associated with EED without other underlying pathologies [6], or with IgA monoclonal gammopathy [7] or myelodysplastic syndrome [8].…”

Section: Discussionsupporting

confidence: 63%

Associated Pyoderma Gangrenosum, Erythema Elevatum Diutinum, and Chronic Recurrent Annular Dermatosis: The Neutrophilic Disease Spectrum

Alj¹,

Eljazouly²,

Chahboun³

et al. 2022

Cureus

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Neutrophilic dermatoses (ND) refer to a group of skin diseases characterized histologically by a cutaneous infiltrate of mature polymorphonuclear cells without an identifiable cause. Previously described as autonomous, these clinically distinct entities are included in the spectrum of neutrophilic disease due to the existence of overlapping forms, as described in our observation. Erythema elevatum diutinum (EED) is a rare dermatosis characterized by reddish-violaceous to browning papulonodular and plaques and belongs to the spectrum of cutaneous leukocytoclastic vasculitis. Chronic recurrent annular neutrophilic dermatosis (CRAND) is an exceptional neutrophilic dermatosis characterized by chronic annular lesions and the absence of generalized signs or hematological abnormalities. Histological features are similar to those seen in Sweet's syndrome.A 55-year-old woman with a history of pyoderma gangrenosum (PG) presented successively with two rare forms of ND, namely, EED and CRAND. There were no clinical or paraclinical arguments for any underlying systemic disease. Treatment with azathioprine 100 mg/day and topical steroids led to a total regression of lesions after a nine-month follow-up.Our observation is important because it reports two rare entities, CRAND and EED. Their occurrence in a single patient with a history of PG illustrates the concept of "neutrophilic disease" reported in the 1990s.

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Section: Discussionsupporting

confidence: 63%

Associated Pyoderma Gangrenosum, Erythema Elevatum Diutinum, and Chronic Recurrent Annular Dermatosis: The Neutrophilic Disease Spectrum

Alj¹,

Eljazouly²,

Chahboun³

et al. 2022

Cureus

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“…Few cased of EED with PG have been reported, [1][2][3] and this case is the second case in Japan. As EED and PG are both neutrophilic dermatoses of the same spectrum, 1 cases of EEDs complicated by PG may not be surprising.…”

Section: Discussionmentioning

confidence: 77%

“…1 Given the increased risk of non-melanoma skin cancer in chronic lymphocytic leukaemia patients, combined dermatology and haematology clinics have been established to better manage these patients. 3 We aim to determine the features of metastatic squamous cell carcinoma in chronic lymphocytic leukaemia from six patients at a combined dermatology-haematology clinic in Australia.…”

Section: Introductionmentioning

confidence: 99%

A case of erythema elevatum diutinum with pyoderma gangrenosum

et al. 2023

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Neutrophilic and eosinophilic dermatoses associated with hematological malignancy

Maronese,

Derlino,

Moltrasio

et al. 2024

Front. Med.

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Cutaneous manifestations of hematologic malignancy represent both a clinical challenge for the treating physician and a pathophysiological model for advancing the knowledge on individual neoplasms. Indeed, a growing body of evidence supports the concept of recurrent molecular defects associating with specific clinical features, as best exemplified by VEXAS. Herein neutrophilic and eosinophilic dermatoses of potential interest for both hematologists and dermatologists will be reviewed, including subcorneal pustular dermatosis-type IgA pemphigus, neutrophilic eccrine hidradenitis, Sweet’s syndrome as well as myelodysplasia cutis and VEXAS, pyoderma gangrenosum, eosinophilic annular erythema, eosinophilic dermatosis of hematological malignancy, Wells syndrome and cutaneous involvement in hypereosinophilic syndromes. Possible management approaches are discussed for each, emphasizing scenarios that require treatment of the underlying condition to achieve remission at the skin level.

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Pyoderma gangrenosum and erythema elevatum diutinum associated with a high-risk myelodysplastic syndrome: case report

Cited by 3 publications

References 10 publications

Associated Pyoderma Gangrenosum, Erythema Elevatum Diutinum, and Chronic Recurrent Annular Dermatosis: The Neutrophilic Disease Spectrum

Associated Pyoderma Gangrenosum, Erythema Elevatum Diutinum, and Chronic Recurrent Annular Dermatosis: The Neutrophilic Disease Spectrum

A case of erythema elevatum diutinum with pyoderma gangrenosum

Neutrophilic and eosinophilic dermatoses associated with hematological malignancy

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