Red blood cell alloantibodies and autoantibodies: different presentation, same physiopathology

Dinardo, Carla Luana

doi:10.1016/j.htct.2017.09.002

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…Transfusion-related alloimmunization was found to depends mainly on the dose (the extent of transfusions and the absolute number of antigens per RBC) and immunogenicity of the antigen 41 as the blood group antigen dose per RBC may vary from only a few to more than a million antigens per RBC 42 . However, the ability of developing red blood cell alloantibodies found to be restricted to a specific group of blood recipients, whose genetics and inflammation milieu favor the antigen presentation and augment the Th2 response 43 . Various patient-related factors may also influence the response to these antigens 16 ; therefore, these variables should be explored in attempt to prevent this complex phenomenon.…”

Section: Discussionmentioning

confidence: 99%

A study of red blood cell alloimmunization and autoimmunization among 200 multitransfused Egyptian β thalassemia patients

El‐Beshlawy

Salama

El-Masry

et al. 2020

Sci Rep

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The development of hemolytic erythrocyte alloantibodies and autoantibodies complicates transfusion therapy in thalassemia patients. These antibodies ultimately increase the need for blood and intensify transfusion complications. There is a scanty data on the frequency of RBC alloimmunization and autoimmunization in Egyptian β thalassemia patients as pretransfusion antibody screening is not routinely performed. We studied the frequency of alloimmunization and autoimmunization among 200 multiply transfused β thalassemia patients and investigated the factors that possibly affect antibody formation. Of the 200 patients in our study, 94 were males and 106 females, with the age range of 2–37 years. Alloantibodies were detected in 36 (18%) of the patients, while autoantibodies were detected in 33 (16.5%). The dominant alloantibodies were directed against Kell (33%) and Rh (24.4%) groups. Alloimmunization had a significant relationship with treatment duration and the frequency of transfusion (P = 0.007, 0.001, respectively). The presence of autoantibodies was significantly related to age (P = 0.001), total number of transfused units (P = 0.000) and splenectomy (P = 0.000). The high prevalence of alloimmunization in the study population disclosed the need for providing phenotypically matched cells for selective antigens especially for Kell and Rh subgroups to reduce risk of alloimmunization and increase the efficiency of blood transfusion.

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Section: Discussionmentioning

confidence: 99%

A study of red blood cell alloimmunization and autoimmunization among 200 multitransfused Egyptian β thalassemia patients

El‐Beshlawy

Salama

El-Masry

et al. 2020

Sci Rep

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Skewed intracellular cytokine production of iNKT cells toward Th2-related responses in alloimmunized thalassemia patients

et al. 2021

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Phenotyping of Rh and Kell blood group antigen in thalassemia and its impact on alloimmunization in a tertiary care hospital

Gupta,

Kumar

2024

JLP

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Objectives: Alloimmunization to red cell antigens is a dreaded complication in multitransfused patients, leading to difficulty in obtaining compatible red blood cell units and development of delayed hemolytic transfusion reactions. The objective of this study was to assess the impact of partial matched phenotype blood (for RhD, C, c, E, e, and Kell antigens) on alloimmunization in thalassemics versus non-phenotype matched blood (ABO & RhD). Materials and Methods: This cross-sectional study was conducted over a period of two years where 250 patients with thalassemias were enrolled. They were divided into two groups, patients in Group I (n = 180) who received partial matched phenotype blood since initiation of transfusion therapy and those in Group II (n = 70) subjects who received usual matched blood. Statistical analysis: All statistical calculations were done using statistical package for the social sciences (SPSS) 21 version. Data were described in terms of range, median (interquartile range [IQR]), frequencies, etc. Results: The median (IQR) age of the study population was 12 (7–18) years (range 6 months–36 years). The most common Rh antibodies were anti-D (2.85%), anti-E (2.85%), anti-C (1.42%), and anti-c (1.42%), and Kell antibodies were (7.1%). It was seen that chances of developing autoantibodies (37% vs. 5%), alloantibodies 11 (15.7% vs. 0%), and transfusion reactions 25 (35.7% vs. 3.3%) were more in Group II subjects as compared to Group I. A significant difference was seen with febrile non-hemolytic transfusion reactions in between two groups 0.001 (95% confidence interval 2.98–65.73). Conclusions: Patients with thalassemia should be typed for RhD (C, c, E, and e) and Kell antigen before initiation of transfusion, which will help in reducing the rate of alloimmunization, autoimmunization, and frequency of transfusion and will improve the overall survival rate in thalassemia.

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Red blood cell alloantibodies and autoantibodies: different presentation, same physiopathology

Cited by 3 publications

References 5 publications

A study of red blood cell alloimmunization and autoimmunization among 200 multitransfused Egyptian β thalassemia patients

A study of red blood cell alloimmunization and autoimmunization among 200 multitransfused Egyptian β thalassemia patients

Skewed intracellular cytokine production of iNKT cells toward Th2-related responses in alloimmunized thalassemia patients

Phenotyping of Rh and Kell blood group antigen in thalassemia and its impact on alloimmunization in a tertiary care hospital

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