Maternal consumption of caffeine and second-hand tobacco smoke as risk factors for the development of oral clefts

Andrade, Rodrigo Soares de; Oliveira, Fabrício Emanuel Soares de; Martelli, Daniella Reis Barbosa; Barros, Letízia Monteiro de; Júnior, Hercílio Martelli

doi:10.1016/j.clinsp.2023.100266

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…Given the common nature of coffee consumption among pregnant women, even a slight increase in the risk of malformations warrants caution [ 20 ]. In a systematic review of studies on OFC and caffeine, high intake was associated with a slight elevation in risk [ 21 ]. While the exact mechanism by which coffee consumption increases the risk of oral cleft remains unclear, it is believed that the effect on homocysteine levels contributes to the heightened risk of CL/P [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Distribution of maternal risk factors for orofacial cleft in infants in Indonesia: a multicenter prospective study

Tajrin,

Ruslin,

Rasul

et al. 2024

Arch Craniofac Surg

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Background: The pathogenesis of orofacial cleft (OFC) is multifactorial, involving both genetic and non-genetic factors, the latter of which play a key role in the development of these anomalies. This paper addresses the incidence of OFC in Indonesia, with a focus on identifying and examining the distribution of contributory factors, including parental medical history, pregnancy history, and environmental influences.Methods: The study was conducted through the collection of primary data. An interdisciplinary research team from Indonesia administered a standardized questionnaire to parents who had children with OFC and who had provided informed consent. The case group comprised 133 children born with cleft lip and/or palate, and the control was 133 noncleft children born full-term. The risk factors associated with OFC anomalies were analyzed using the chi-square test and logistic regression. All statistical analyses were performed using SPSS version 25. A p-value of 0.05 or less was considered to indicate statistical significance.Results: The study comprised 138 children, of whom 82 were boys (59.4%) and 56 were girls (40.6%). Among them, 45 patients (32.6%) presented with both cleft lip and cleft palate, 25 individuals (18.1%) had a cleft palate only, and 28 patients (20.3%) had a cleft lip only. OFC was found to be significantly associated with a maternal family history of congenital birth defects (p< 0.05), complications during the first trimester (p< 0.05), consumption of local fish (p< 0.05), caffeine intake (p< 0.05), prolonged medication use (p< 0.05), immunization history (p< 0.05), passive smoking (p< 0.05), and X-ray exposure during pregnancy (p< 0.05).Conclusion: The findings indicate close relationships between the incidence of OFC and maternal medical history, prenatal factors, and environmental influences.

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Section: Discussionmentioning

confidence: 99%

Distribution of maternal risk factors for orofacial cleft in infants in Indonesia: a multicenter prospective study

Tajrin,

Ruslin,

Rasul

et al. 2024

Arch Craniofac Surg

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“…Peran nutrisi seperti asam folat dan vitamin sangat dibutuhkan sejak merencanakan kehamilan hingga awal kehamilan sebagai bentuk pencegahan cacat bawaan pada janin (Regina Altoé et al, 2020). Asam folat dan vitamin B12 pada awal kehailan berperan pada proses fusi dan perkembangan maxilla sehingga kuranganya asupan asam folat meningkatkan terjadinya cacat sumbing pada janin (de Andrade et al, 2023;Munger et al, 2021). Pemenuhan konsumsi asam folat dan vitamin dengan suplemen multivitamin dapat menjadi pilihan untuk memenuhi kebutuhan vitamin, tetapi harus diperhatika dengan baik kadar yang diperlukan hariaannya agar tidak berlebih.…”

Section: Hasil Dan Pembahasanunclassified

“…Selain itu, gaya hidup selama kehamilan seperti merokok dan mengkonsumsi kafein juga dapat meingkatkan resiko terjadinya cacat sumbing pada janin (de Andrade et al, 2023). Rokok memiliki kandungna carbon monoksida dan polycyclic aromatic hydrocarbons yang menyebabkan hipoksia pada janin serta mengganggu mekanisme metabolism janin yang dapat meningkatkan resiko cacat bawaan pada janin (Alswairki et al, 2019;Auslander et al, 2020).…”

Section: Hasil Dan Pembahasanunclassified

Faktor Resiko Ibu terhadap Kelahiran Anak dengan Labiopalatognatoschizis (Cacat Sumbing): Literature Review

Adriyansyah,

Nurhidayati

2024

jsi

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Labiopalatognatoschizis atau cacat sumbing merupakan kelanan bawaan yang paling umum terjadi di area orofasial. Berbagai faktor risiko dapat menjadi pemicu terjadinya cacat sumbing khususnya genetik dan lingkungan yang berkaitan dengan ibu hamil. Artikel ini bertujuan untuk meninjau kembali faktor resiko yang dapat mempengaruhi kondisi sumbing pada janin terutama dari faktor resikor ibu untuk mencegah terjadinya kelahiran dengan cacat sumbing. Pencarian literatur dengan kata kunci yang sesuai dilakukan pada database PubMed. Sebanyak empat artikel memenuhi kriteria eligibilitas yang akan dilanjutkan peninjauan lebih lanjut. Tinjauan terhadap empat artikel ini menunjukan bahwa faktor resiko yang dapat meningkatkan kemungkinan terjadinya cacat sumbing adalah, konsumsi multivitamin yang berlebihan pada awal kehamilan, Ibu yang merokok aktif atau pasif, serta ibu yang memiliki riwayat masalah metabolism seperti obesitas, diabetes, dan hipertensi pada masa kehamilan memiliki resiko yang lebih tinggi untuk melahirkan anak dengan cacat sumbing. Penelitian lebih lanjut dibutuhkan untuk meninjau lebih luas lagi terkait faktor resiko terjadinya cacat sumbing pada janin.

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A comprehensive consolidation of data on the relationship between IRF6 polymorphisms and non-syndromic cleft lip/palate susceptibility: From 79 case-control studies

Golshan-Tafti,

Dastgheib,

Bahrami

et al. 2024

Journal of Stomatology, Oral and Maxillofacial Surgery

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Maternal consumption of caffeine and second-hand tobacco smoke as risk factors for the development of oral clefts

Cited by 3 publications

References 33 publications

Distribution of maternal risk factors for orofacial cleft in infants in Indonesia: a multicenter prospective study

Distribution of maternal risk factors for orofacial cleft in infants in Indonesia: a multicenter prospective study

Faktor Resiko Ibu terhadap Kelahiran Anak dengan Labiopalatognatoschizis (Cacat Sumbing): Literature Review

A comprehensive consolidation of data on the relationship between IRF6 polymorphisms and non-syndromic cleft lip/palate susceptibility: From 79 case-control studies

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