The effect of sperm DNA fragmentation on in vitro fertilization outcomes of unexplained infertility

Wang, Qingxin; Gu, Xiuli; Chen, Yannan; Yu, Minyan; Peng, Lingna; Zhong, Shuping; Wang, Xia; Lv, Jinxing

doi:10.1016/j.clinsp.2023.100261

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…70 In agreement with these results, a recent retrospective study involving 176 couples with unexplained infertility undergoing IVF or ICSI showed that SDF levels >25% were significantly correlated with a decrease in the number of day 3 good-quality embryos ( r = −0.347, p < 0.001). 71 In contrast to these findings, previous systematic reviews that gathered evidence from numerous sources did not establish a clear association. For instance, in a 2011 systematic review evaluating a total of 3,226 IVF and ICSI cycles, SDF was linked to poor embryo quality in less than half of the included studies (11/28), 43 a finding corroborated by Simon et al in 2017.…”

Section: Sperm Dna Fragmentation and Assisted Reproductive Technologymentioning

confidence: 71%

Unraveling the Impact of Sperm DNA Fragmentation on Reproductive Outcomes

Nielsen,

Majzoub,

Esteves

et al. 2023

Semin Reprod Med

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In recent years, there has been a growing interest in identifying subcellular causes of male infertility, and sperm DNA fragmentation (SDF) research has been at the forefront of this focus. DNA damage can occur during spermatogenesis due to faulty chromatin compaction or excessive abortive apoptosis. It can also happen as sperm transit through the genital tract, often induced by oxidative stress. There are several methods for SDF testing, with the sperm chromatin structure assay, terminal deoxynucleotidyl transferase d-UTI nick end labeling (TUNEL) assay, comet assay, and sperm chromatin dispersion test being the most commonly used. Numerous studies strongly support the negative impact of SDF on male fertility potential. DNA damage has been linked to various morphological and functional sperm abnormalities, ultimately affecting natural conception and assisted reproductive technology outcomes. This evidence-based review aims to explore how SDF influences male reproduction and provide insights into available therapeutic options to minimize its detrimental impact.

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Section: Sperm Dna Fragmentation and Assisted Reproductive Technologymentioning

confidence: 71%

Unraveling the Impact of Sperm DNA Fragmentation on Reproductive Outcomes

Nielsen,

Majzoub,

Esteves

et al. 2023

Semin Reprod Med

View full text Add to dashboard Cite

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Integrating artificial intelligence into the modernization of traditional Chinese medicine industry: a review

Zhou,

Shen,

Hou

2024

Front. Pharmacol.

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Traditional Chinese medicine (TCM) is the practical experience and summary of the Chinese nation for thousands of years. It shows great potential in treating various chronic diseases, complex diseases and major infectious diseases, and has gradually attracted the attention of people all over the world. However, due to the complexity of prescription and action mechanism of TCM, the development of TCM industry is still in a relatively conservative stage. With the rise of artificial intelligence technology in various fields, many scholars began to apply artificial intelligence technology to traditional Chinese medicine industry and made remarkable progress. This paper comprehensively summarizes the important role of artificial intelligence in the development of traditional Chinese medicine industry from various aspects, including new drug discovery, data mining, quality standardization and industry technology of traditional Chinese medicine. The limitations of artificial intelligence in these applications are also emphasized, including the lack of pharmacological research, database quality problems and the challenges brought by human-computer interaction. Nevertheless, the development of artificial intelligence has brought new opportunities and innovations to the modernization of traditional Chinese medicine. Integrating artificial intelligence technology into the comprehensive application of Chinese medicine industry is expected to overcome the major problems faced by traditional Chinese medicine industry and further promote the modernization of the whole traditional Chinese medicine industry.

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The effect of sperm DNA fragmentation on in vitro fertilization outcomes of unexplained infertility

Cited by 2 publications

References 27 publications

Unraveling the Impact of Sperm DNA Fragmentation on Reproductive Outcomes

Unraveling the Impact of Sperm DNA Fragmentation on Reproductive Outcomes

Integrating artificial intelligence into the modernization of traditional Chinese medicine industry: a review

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