Efficacy, safety, and potential industry bias in using deoxycholic acid for submental fat reduction ‒ A systematic review and meta-analysis of randomized clinical trials

Inocêncio, Gabriel Santiago Giuglio; Meneses-Santos, Daniela; Costa, Marcelo Dias Moreira de Assis; Vieira, Walbert A.; de Almeida, Vinicius Lima; Rodrigues, Renata Prata Cunha Bernardes; Rode, Sigmar de Mello; Paranhos, Luiz Renato

doi:10.1016/j.clinsp.2023.100220

Clinics

2023

DOI: 10.1016/j.clinsp.2023.100220

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Efficacy, safety, and potential industry bias in using deoxycholic acid for submental fat reduction ‒ A systematic review and meta-analysis of randomized clinical trials

Gabriel Santiago Giuglio Inocêncio,

Daniela Meneses-Santos,

Marcelo Dias Moreira de Assis Costa

et al.

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2024

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Cited by 2 publications

References 35 publications

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A novel approach for deoxycholic acid administration to treat submental fullness: A case report assessed by 3D stereophotogrammetry

Rogerio,

Rabelo,

Roschel

et al. 2024

Journal of Oral Biology and Craniofacial Research

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A novel approach for deoxycholic acid administration to treat submental fullness: A case report assessed by 3D stereophotogrammetry

Rogerio,

Rabelo,

Roschel

et al. 2024

Journal of Oral Biology and Craniofacial Research

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Characterization of individual bile acids in vivo utilizing a novel low bile acid mouse model

Taylor,

Yang,

Henry

et al. 2024

Toxicological Sciences

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Bile acids (BAs) are signaling molecules synthesized in the liver initially by CYP7A1 and CYP27A1 in the classical and alternative pathways, respectively. BAs are essential for cholesterol clearance, intestinal absorption of lipids, and endogenous modulators of farnesoid x receptor (FXR). FXR is critical in maintaining BA homeostasis and gut-liver crosstalk. Complex reactions in vivo and the lack of suitable animal models impede our understanding of the functions of individual BAs. In this study, we characterized the in vivo effects of three-day feeding of cholic acid (CA), deoxycholic acid (DCA), or ursodeoxycholic acid (UDCA) at physiological/non-hepatotoxic concentrations in a novel low-BA mouse model (Cyp7a1 -/-/Cyp27a1 -/-, DKO). Liver injury, BA levels and composition and BA signaling by the FXR-fibroblast growth factor 15 (FGF15) axis were determined. Overall, higher basal inflammation and altered lipid metabolism in DKO mice might be associated with low BAs. CA, DCA and UDCA feeding activated FXR signals with tissue specificity. Dietary CA and DCA similarly altered tissue BA profiles to be less hydrophobic, while UDCA promoted a more hydrophobic tissue BA pool with the profiles shifted towards non-12α-OH BAs and secondary BAs. However, UDCA did not offer any overt protective effects as expected. These findings allow us to determine the precise effects of individual BAs in vivo on BA-FXR signaling and overall BA homeostasis in liver physiology and pathologies.

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Efficacy, safety, and potential industry bias in using deoxycholic acid for submental fat reduction ‒ A systematic review and meta-analysis of randomized clinical trials

Cited by 2 publications

References 35 publications

A novel approach for deoxycholic acid administration to treat submental fullness: A case report assessed by 3D stereophotogrammetry

A novel approach for deoxycholic acid administration to treat submental fullness: A case report assessed by 3D stereophotogrammetry

Characterization of individual bile acids in vivo utilizing a novel low bile acid mouse model

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