Intra-abdominal desmoid tumors in familial adenomatous polyposis: How much do clinical and surgical variables interfere with their development?

Campos, Fábio Guilherme; Bustamante-Lopez, Leonardo Alfonso; Mendonça, Roberta Laís da Silva; Kanno, Danillo Toshio

doi:10.1016/j.clinsp.2022.100144

Cited by 1 publication

(1 citation statement)

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“…This was recapitulated in a study by Campos et al who demonstrated no association between extent of resection (TPC vs. TAC) and approach (laparoscopic vs. open) with risk of DT formation. 42 Importantly, a metaanalysis of publications between 1989 and 2019 by Xie et al with 1,072 patients found similar DT incidence after IPAA versus IRA (11.8% vs. 9.5%, odds ratio 0.95, p ¼ 0.85). 38 Ultimately, the extent of operation, approach, and timing of colectomy for FAP patients should be based on neoplastic and other patient factors and not desmoid burden (although the presence of DTs may require a more experienced surgeon or treatment center) (►Table 2).…”

Section: Desmoid Disease and The Need For Proctectomymentioning

confidence: 93%

Surgical Decision-Making in Familial Adenomatous Polyposis

Steinberger,

Westfal,

Wise

2023

Clin Colon Rectal Surg

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Familial adenomatous polyposis (FAP) is an autosomal dominant disorder affecting patients with germline mutations of the adenomatous polyposis coli (APC) tumor suppressor gene. The surgical treatment of colorectal disease in FAP, which has the goal of colorectal cancer prevention, varies based on both patient and disease factors but can include the following: total colectomy with ileorectal anastomosis, proctocolectomy with stapled or hand-sewn ileal pouch-anal anastomosis, or total proctocolectomy with end ileostomy. The operative options and extent of resection, as well as the use of endoscopy and chemoprevention for the management of polyposis, will be discussed in detail in this article. In addition, commonly debated management decisions related to the treatment of patients with FAP, including the timing of prophylactic colorectal resections for patients with FAP and management of the polyp burden in the rectum, will be discussed. Finally, genotype considerations and the impact of desmoid disease on operative decisions in the setting of FAP will also be reviewed.

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Section: Desmoid Disease and The Need For Proctectomymentioning

confidence: 93%