2022
DOI: 10.1016/j.clinsp.2022.100123
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High expression of prolyl 4-hydroxylase subunit alpha-2 in lung adenocarcinoma indicates poor prognosis

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Cited by 3 publications
(6 citation statements)
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“…Except for cellular tumor antigen p53 (TP53), the other 11 proteins have been shown to be upregulated in different types of cancer (Table S6). Six of these proteins are involved in the folding, aggregation, or turnover of proteins [hypoxia up-regulated protein 1 (HYOU1), heat shock 70 kDa protein 1A or 1B (HSPA1A or 1B), protein disulfide-isomerase (P4HB), prolyl 4-hydroxylase subunit alpha-2 (P4HA2), serpin H1 (SERPINH1), ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1)]. Two are involved in l -serine biosynthesis [phosphoserine aminotransferase (PSAT1), phosphoserine phosphatase (PSPH)].…”
Section: Resultsmentioning
confidence: 99%
“…Except for cellular tumor antigen p53 (TP53), the other 11 proteins have been shown to be upregulated in different types of cancer (Table S6). Six of these proteins are involved in the folding, aggregation, or turnover of proteins [hypoxia up-regulated protein 1 (HYOU1), heat shock 70 kDa protein 1A or 1B (HSPA1A or 1B), protein disulfide-isomerase (P4HB), prolyl 4-hydroxylase subunit alpha-2 (P4HA2), serpin H1 (SERPINH1), ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1)]. Two are involved in l -serine biosynthesis [phosphoserine aminotransferase (PSAT1), phosphoserine phosphatase (PSPH)].…”
Section: Resultsmentioning
confidence: 99%
“…Complete deletion of P4ha2 had a higher effect on the reduced deposition of collagen I in the ECM implicating perturbed ECM remodeling [54,55]. ECM remodeling has emerged as an important mechanism during the progression of tissue metastasis [55][56][57]. Elevated levels of P4ha2 are associated with poor prognosis and progression of metastasis in many cancerous tissues of the human body [56,57].…”
Section: Discussionmentioning
confidence: 99%
“…ECM remodeling has emerged as an important mechanism during the progression of tissue metastasis [55][56][57]. Elevated levels of P4ha2 are associated with poor prognosis and progression of metastasis in many cancerous tissues of the human body [56,57]. It has even been reported that inhibition/deletion of P4ha2 attenuates the metastasis progression and reduces the deposition of collagen molecules in ECM [54,55].…”
Section: Discussionmentioning
confidence: 99%
“…Numerous intricate processes are involved in the manufacture and deposition of collagen, and many post-transcription modification proteins control these activities [ 6 ]. Prolyl 4-hydroxylase subunit Alpha-2 (P4HA2), a crucial enzyme in collagen manufacture, is made up of two alpha and two beta subunits, which are identical to each other [ 7 ]. According to reports, P4HA2 causes extracellular matrix remodeling when the oxygen level is low [ 8 ].…”
Section: Introductionmentioning
confidence: 99%
“…According to Cao et al [ 10 ], P4HA2 functions as an oncogenic agent by inducing EMT in cervical cancer cells, thereby enhancing their motility, invasion, and proliferation. Accumulating evidence has confirmed that P4HA2 overexpression in multiple cancers, including lung adenocarcinoma, prostate cancer, glioma, and cervical cancer, has a correlation to patient prognosis [ 7 , 11 ]. Kisoda et al [ 12 ].…”
Section: Introductionmentioning
confidence: 99%