Resveratrol attenuates chronic pulmonary embolism-related endothelial cell injury by modulating oxidative stress, inflammation, and autophagy

Liu, Xiaopeng; Zhou, Haiying; Hu, Zhixiong

doi:10.1016/j.clinsp.2022.100083

Cited by 5 publications

(3 citation statements)

References 43 publications

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“…The echocardiographic findings in our study support right ventricle dilatation in the thrombolytic group. Higher oxygen consumption is caused by shear stress in the ventricular wall, neurohormonal activation, and tachycardia [ 13 ]. Hypoxemia and hypotension may result in mortality [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

The Importance of Frontal QRS-T Angle in Predicting the Effectiveness and Success of Thrombolytic Therapy in Patients With Acute Pulmonary Embolism

Durğun¹,

Karahan²

2023

Cureus

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Objective: The frontal QRS-T angle (fQRS-T) is associated with myocardial ischemia and ventricular arrhythmias. On the other hand, acute pulmonary embolism (APE) is a major risk factor for cardiac adverse events. This research aimed to determine whether the fQRS-T, a marker of ventricular heterogeneity, can be used to predict successful thrombolytic therapy in patients with APE.Methods: This was a retrospective observational study. Patients diagnosed with APE and hospitalized in the intensive care unit between 2020 and 2022 were included in the research. A total of 136 individuals with APEs were enrolled in this research. The patients were divided into two groups: thrombolytic-treated (n=64) and non-treated (moderate to severe risk, n=72). An ECG was conducted for each patient, and echocardiography was performed.Results: The mean age of the thrombolytic group was 58.2±17.6 years, with 35 females (55.1% of the group) and 29 males (44.9%). The non-thrombolytic group had a mean age of 63.1±16.2, with 41 females (56.5%) and 31 males (43.5%). Respiratory rate, heart rate, and fQRS-T were higher in the thrombolytic group, and oxygen saturation ratio and systolic and diastolic blood pressure were higher in the non-thrombolytic group (p=0.006, p<0.001, p=0.021; p<0.001, p=0.015, p<0.001, respectively). In the thrombolytic therapy group, comparing pre-and post-treatment ECG data revealed a statistically significant change in the fQRS-T value (p=0.019). Conclusion:The fQRS-T may provide important clues for the successful treatment of APEs.

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Section: Discussionmentioning

confidence: 99%

The Importance of Frontal QRS-T Angle in Predicting the Effectiveness and Success of Thrombolytic Therapy in Patients With Acute Pulmonary Embolism

Durğun¹,

Karahan²

2023

Cureus

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“…Dietary polyphenols are classified as flavonoids, which comprises the major group of polyphenolic compounds, and non-flavonoid polyphenols [55,71]. Stilbenes, a non-flavonoid polyphenol, contain resveratrol that shows a variety of biological activities, including antioxidant, anti-inflammatory, and anti-tumor properties, and has been shown to improve PH [72]. Several studies have reported that resveratrol in MCT-induced PAH rats suppresses PASMC proliferation and pulmonary vessel muscularization [73,74].…”

Section: Polyphenolsmentioning

confidence: 99%

“…Several studies have reported that resveratrol in MCT-induced PAH rats suppresses PASMC proliferation and pulmonary vessel muscularization [73,74]. The effects of resveratrol have been also studied in a CTEPH model, where it showed a reduction in vascular injury and pulmonary arterial pressure, not only by promoting SOD expression and scavenging ROS, but also inhibiting inflammation and platelet activation [72].…”

Section: Polyphenolsmentioning

confidence: 99%

Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension

et al. 2023

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Pulmonary hypertension (PH) is a progressive disease characterized by elevated artery pressures and pulmonary vascular resistance. Underlying mechanisms comprise endothelial dysfunction, pulmonary artery remodeling and vasoconstriction. Several studies have shown evidence of the critical role of oxidative stress in PH pathophysiology. Alteration of redox homeostasis produces excessive generation of reactive oxygen species, inducing oxidative stress and the subsequent alteration of biological molecules. Exacerbations in oxidative stress production can lead to alterations in nitric oxide signaling pathways, contributing to the proliferation of pulmonary arterial endothelial cells and smooth muscle cells, inducing PH development. Recently, antioxidant therapy has been suggested as a novel therapeutic strategy for PH pathology. However, the favorable outcomes observed in preclinical studies have not been consistently reproduced in clinical practice. Therefore, targeting oxidative stress as a therapeutic intervention for PH is an area that is still being explored. This review summarizes the contribution of oxidative stress to the pathogenesis of the different types of PH and suggests antioxidant therapy as a promising strategy for PH treatment.

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Resveratrol can improve spinal cord injury by activating Nrf2/HO-1 signaling pathway

Tang,

Botchway,

Zhang

et al. 2024

Annals of Anatomy - Anatomischer Anzeiger

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Resveratrol attenuates chronic pulmonary embolism-related endothelial cell injury by modulating oxidative stress, inflammation, and autophagy

Cited by 5 publications

References 43 publications

The Importance of Frontal QRS-T Angle in Predicting the Effectiveness and Success of Thrombolytic Therapy in Patients With Acute Pulmonary Embolism

The Importance of Frontal QRS-T Angle in Predicting the Effectiveness and Success of Thrombolytic Therapy in Patients With Acute Pulmonary Embolism

Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension

Resveratrol can improve spinal cord injury by activating Nrf2/HO-1 signaling pathway

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