Expression of ezrin protein and phosphorylated ezrin in pelvic endometriotic lesions

Peloggia, Alessandra; Andres, Marina Paula; Abrão, Maurício Simões

doi:10.1016/j.clinsp.2022.100074

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…The periodic alteration of the endometrium is vital for initiating and sustaining a successful pregnancy. Cellular and tissue remodeling is necessary for all these activities, and ezrin is needed to rearrange the cytoskeleton and cell-cell attachment in the endometrium ( Peloggia et al, 2022 ). It was observed that the expression of ezrin was significantly enhanced during the secretory phase, and during the implantation window, ezrin was detected to enter the glandular lumens ( Guo et al, 2021 ).…”

Section: The Biological Function Of Ezrin In the Female Reproductive ...mentioning

confidence: 99%

“…Ezrin can interact with thrombomodulin (TM), a membrane protein critical for the formation of the placenta. Ezrin-Thrombomodulin, a complex protein, facilitates the connection of actin filaments of the cytoskeleton to the cell surface, thus enabling the expression and arrangement of pinopodes ( Peloggia et al, 2022 ). During implantation, estrogens and progesterone trigger the binding of TM to ezrin, as well as the phosphorylation and activation of ezrin.…”

Section: The Biological Function Of Ezrin In the Female Reproductive ...mentioning

confidence: 99%

“…In some biological processes of female reproduction, such as endometrial hyperplasia and embryo implantation, tumor-like biological properties exist ( Li et al, 2022 ). Recent studies have shown that the expression and localization of ezrin have been altered in tissues related to endometriosis ( Peloggia et al, 2022 ), recurrent miscarriage ( Zhang et al, 2022a ), gestational trophoblastic disease ( Tameishi et al, 2021 ), and polycystic ovary syndrome (PCOS) ( Demacopulo and Kreimann, 2019 ), sparking our interest. This review provides a summary of recent studies on the modalities of ezrin regulation and its involvement in the biological processes of female reproductive system physiopathology.…”

Section: Introductionmentioning

confidence: 99%

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Ezrin expression in female reproductive tissues: A review of regulation and pathophysiological implications

Shi²,

Xu³

et al. 2023

Front. Cell Dev. Biol.

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Ezrin, a plasma membrane-microfilament linker, is a cytoskeletal organizer involved in many cellular activities by binding to the membrane protein-ezrin-cytoskeletal protein complex and regulating downstream signal transduction. Increasing evidence demonstrates that ezrin plays an important role in regulating cell polarity, proliferation and invasion. In this study, we analyzed the effects of ezrin on oocytes, follicle development, embryo development and embryo implantation. We reviewed the recent studies on the modalities of ezrin regulation and its involvement in the biological processes of female reproductive physiology and summarized the current research advances in ezrin inhibitors. These studies will provide new strategies and insights for the treatment of diseases.

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Section: The Biological Function Of Ezrin In the Female Reproductive ...mentioning

confidence: 99%

Section: The Biological Function Of Ezrin In the Female Reproductive ...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ezrin expression in female reproductive tissues: A review of regulation and pathophysiological implications

Shi²,

Xu³

et al. 2023

Front. Cell Dev. Biol.

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Ezrin's role in gastric cancer progression: Implications for immune microenvironment modulation and therapeutic potential

Zhu,

Zhang,

Chen

et al. 2024

Heliyon

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Ectopic pregnancy: search for biomarker in salivary proteome

Priya Aarthy,

Sen,

Srinivasan

et al. 2023

Sci Rep

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Ectopic pregnancy (EP) is associated with high maternal morbidity and mortality. Ultrasonography is the only dependable diagnostic tool for confirming an ectopic pregnancy. In view of inadequate early detection methods, women suffer from a high-life risk due to the severity of EP. Early detection of EP using pathological/molecular markers will possibly improve clinical diagnosis and patient management. Salivary proteins contain potential biomarkers for diagnosing and detecting various physiological and/or pathological conditions. Therefore, the present investigation was designed to explore the salivary proteome with special reference to EP. Gel-based protein separation was performed on saliva, followed by identification of proteins using Liquid Chromatography-Tandem Mass Spectrometry (LC–MS/MS). Totally, 326 proteins were identified in the salivary samples, among which 101 were found to be specific for ruptured ectopic pregnancy (EPR). Reactome analysis revealed innate immune system, neutrophil degranulation, cell surface interactions at the vascular wall, and FCERI-mediated NF-kB activation as the major pathways to which the salivary proteins identified during EPR are associated. Glutathione-S-transferase omega-1 (GSTO1) is specific for EPR and has been reported as a candidate biomarker in the serum of EPR patients. Therefore, saliva would be a potential source of diagnostic non-invasive protein biomarker(s) for EP. Intensive investigation on the salivary proteins specific to EP can potentially lead to setting up of a panel of candidate biomarkers and developing a non-invasive protein-based diagnostic kit.

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Expression of ezrin protein and phosphorylated ezrin in pelvic endometriotic lesions

Cited by 5 publications

References 21 publications

Ezrin expression in female reproductive tissues: A review of regulation and pathophysiological implications

Ezrin expression in female reproductive tissues: A review of regulation and pathophysiological implications

Ezrin's role in gastric cancer progression: Implications for immune microenvironment modulation and therapeutic potential

Ectopic pregnancy: search for biomarker in salivary proteome

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