Incidental thyroid carcinoma: Correlation between FNAB cytology and pathological examination in 1093 cases

Rodrigues, Mariana Gonçalves; Silva, Luiz Fernando Ferraz da; Filho, Vergilius José Furtado de Araújo; Mosca, Letícia de Moraes; Araújo-Neto, Vergilius José Furtado de; Kowalski, Luiz Paulo; Carneiro, Paulo Campos

doi:10.1016/j.clinsp.2022.100022

Cited by 3 publications

(1 citation statement)

References 23 publications

(34 reference statements)

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“…Nonetheless, the evidence-based cancer risk in cytological categories III–IV turned out to be higher as compared to the expected risk rates reported in the BSRTC system (26.5% vs. 5–15% for class III and 31.3% vs. 15–30% for class IV) [ 12 ]. The wrong radiological choice of FNA target was reasonably the main reason for ITCs, probably due to the larger diameters of nodules which underwent FNA (mean size 24 mm vs. 3.7 mm, p < 0.01), prompting the adoption of more efficient US screening algorithms, as previously proposed [ 5 , 13 , 14 , 37 ]. Moreover, we did not find a higher ITC risk in class IV cases compared with class III ones.…”

Section: Discussionmentioning

confidence: 92%

An Indeterminate for Malignancy FNA Report Does Not Increase the Surgical Risk of Incidental Thyroid Carcinoma

Seminati

Mane

Ceola

et al. 2022

Cancers

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Incidental thyroid carcinomas (ITCs) are a fairly frequent finding in daily routine practice, with papillary thyroid microcarcinoma being the most frequent entity. In our work, we isolated incidental cases arising in thyroids removed for other cytologically indeterminate and histologically benign nodules. We retrospectively retrieved cases with available thyroid Fine Needle Aspiration (FNA, 3270 cases), selecting those with an indeterminate cytological diagnosis (Bethesda classes III–IV, 652 cases). Subsequently, we restricted the analysis to surgically treated patients (163 cases) finding an incidental thyroid carcinoma in 22 of them. We found a 13.5% ITC rate, with ITCs representing 46.8% of all cancer histologically diagnosed in this indeterminate setting. Patients received a cytological diagnosis of Bethesda class III and IV in 41% and 59% of cases, respectively. All ITC cases turned out to be papillary thyroid microcarcinomas; 36% of cases were multifocal, with foci bilaterally detected in 50% of cases. We found an overall ITC rate concordant with the literature and with our previous findings. The assignment of an indeterminate category to FNA did not increase the risk of ITCs in our cohort. Rather, a strong statistical significance (p < 0.01) was found comparing the larger size of nodules that underwent FNA and the smaller size of their corresponding ITC nodule.

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Section: Discussionmentioning

confidence: 92%

An Indeterminate for Malignancy FNA Report Does Not Increase the Surgical Risk of Incidental Thyroid Carcinoma

Seminati

Mane

Ceola

et al. 2022

Cancers

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Prediction of cytology–histology discrepancy when Bethesda cytology reports benign results for thyroid nodules in women: with special emphasis on pregnancy

Firat,

Unal

2023

Libyan Journal of Medicine

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Imprinted gene detection effectively improves the diagnostic accuracy for papillary thyroid carcinoma

Chen,

Yin,

Zhang

et al. 2024

BMC Cancer

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Background Papillary thyroid carcinoma (PTC) is the most frequent histological type of thyroid carcinoma. Although an increasing number of diagnostic methods have recently been developed, the diagnosis of a few nodules is still unsatisfactory. Therefore, the present study aimed to develop and validate a comprehensive prediction model to optimize the diagnosis of PTC. Methods A total of 152 thyroid nodules that were evaluated by postoperative pathological examination were included in the development and validation cohorts recruited from two centres between August 2019 and February 2022. Patient data, including general information, cytopathology, imprinted gene detection, and ultrasound features, were obtained to establish a prediction model for PTC. Multivariate logistic regression analysis with a bidirectional elimination approach was performed to identify the predictors and develop the model. Results A comprehensive prediction model with predictors, such as component, microcalcification, imprinted gene detection, and cytopathology, was developed. The area under the curve (AUC), sensitivity, specificity, and accuracy of the developed model were 0.98, 97.0%, 89.5%, and 94.4%, respectively. The prediction model also showed satisfactory performance in both internal and external validations. Moreover, the novel method (imprinted gene detection) was demonstrated to play a role in improving the diagnosis of PTC. Conclusion The present study developed and validated a comprehensive prediction model for PTC, and a visualized nomogram based on the prediction model was provided for clinical application. The prediction model with imprinted gene detection effectively improves the diagnosis of PTCs that are undetermined by the current means.

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Incidental thyroid carcinoma: Correlation between FNAB cytology and pathological examination in 1093 cases

Cited by 3 publications

References 23 publications

An Indeterminate for Malignancy FNA Report Does Not Increase the Surgical Risk of Incidental Thyroid Carcinoma

An Indeterminate for Malignancy FNA Report Does Not Increase the Surgical Risk of Incidental Thyroid Carcinoma

Prediction of cytology–histology discrepancy when Bethesda cytology reports benign results for thyroid nodules in women: with special emphasis on pregnancy

Imprinted gene detection effectively improves the diagnostic accuracy for papillary thyroid carcinoma

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