Arterial stiffness and atrial fibrillation: A review

Lage, João Gabriel Batista; Bortolotto, Alexandre L.; Scanavacca, Maurício; Bortolotto, Luiz Aparecido; Darrieux, Francisco

doi:10.1016/j.clinsp.2022.100014

Cited by 8 publications

(6 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous research has found that stroke patients have higher arterial stiffness and arterial stiffness can significantly predict stroke (5). The main determinants of PWV are age, blood pressure, diabetes status and race, while smoking, lipid levels and gender do not significantly affect PWV (9,13). In our study, age and blood pressure values were higher in the group 2, and cfPWV was also higher.…”

Section: Discussionmentioning

confidence: 99%

“…Various studies have found a connection among arterial stiffness and AF. Arterial stiffness has been shown to have adverse effects on both atrial diameters and strain (9). These factors are also predictive factors for AF and therefore stroke.…”

Section: Discussionmentioning

confidence: 99%

“…According to research, there is a link between arterial stiffness and atrial fibrillation (AF), which causes stroke (9). The CHA 2 DS 2 -VASc scoring system is used to assess stroke risk and initiate anticoagulation in individuals with AF (10).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Relationship between Arterial Stiffness and CHA2DS2-VASc Score in AF-related Stroke Patients

et al. 2023

View full text Add to dashboard Cite

Objective: Arterial stiffness (AS) is related with both AF and stroke. The purpose of this study is to examine the association between AS and CHA2DS2-VASc score in patients with AF-related stroke. Materials and Methods: Thirty stroke patients with non-valvular paroxysmal AF participated in this study. Calculations of the patients' CHA2DS2-VASc scores were made. The Carotid-femoral pulse wave velocity (CF-PWV) measured with the SphygmoCor system was used as an indicator of arterial stiffness. It was determined whether or not there was a statistical connection between the CHA2DS2-VASc score and arterial stiffness. Results: Depending on their CHA2DS2-VASc values before to their stroke, the patients were divided into groups (group 1: score=0-1, group 2=score≥2.) The two groups' characteristics were comparable, with the exception of age and systolic blood pressure. Patients with high CHA2DS2-VASc scores ( group 2) demonstrated significantly greater CF-PWV values than those with low scores (group 1).In correlation analysis, the CHA2DS2-VASc score and the CF-PWV showed positive correlation. Conclusion: The CHA2DS2-VASc score and CF-PWV were substantially and linearly associated. Calculation of CHA2DS2-VASc and monitoring of arterial stiffness in stroke-prone individuals may be stimulus for taking preventive measures from stroke in these patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between Arterial Stiffness and CHA2DS2-VASc Score in AF-related Stroke Patients

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Additionally, autonomic nervous system dysregulation may lead to arterial stiffness [42], a common pathophysiological change attributed to hypertension and aging. While arterial stiffness has been independently associated with OH [43] and AF [44], it may also potentially increase the risk of cardiac arrest [45]. It has been proposed that the development of OH is secondary to autonomic nervous system dysregulation [17], and the development of AF occurs further downstream in the CVD continuum [17,46].…”

Section: Discussionmentioning

confidence: 99%

Atrial Fibrillation as a Prognostic Indicator in Patients With Orthostatic Hypotension: Nationwide Inpatient Sample Analysis

et al. 2022

View full text Add to dashboard Cite

Background: Orthostatic hypotension and atrial fibrillation have common etiology and a bidirectional relationship with several cardiovascular conditions. Despite both conditions being highly prevalent in hospitalized patients, prior research has primarily evaluated adverse outcomes due to orthostatic hypotension and atrial fibrillation independent of each other. In this study, we aim to assess if the presence of atrial fibrillation exacerbates in-hospital outcomes of patients with orthostatic hypotension.Methods: Adult patients hospitalized in 2019 with a primary diagnosis of orthostatic hypotension with or without pre-existing atrial fibrillation were identified using the International Classification of Diseases, Tenth Revision (ICD-10) code. The primary outcome of interest was in-patient mortality and cardiac arrest. Secondary outcomes of interest were the length of stay and total hospital charges. Adjusted and unadjusted analysis was performed on appropriate variables of interest.Results: Among 10,630 hospitalizations with orthostatic hypotension, 2,987 (median (interquartile range (IQR)) age: 78.5 (68.5 -88.5) years; 1,197 women (40.1%)) comprised the atrial fibrillation cohort. Mean Charlson comorbidity index was noted to be significantly higher in orthostatic hypotension and atrial fibrillation patients (mean (standard deviation (SD)): 3.1 (2.1) vs. 2.5 (2.1), P < 0.001).Compared to orthostatic hypotension patients without atrial fibrillation, the prevalence of congestive heart failure (1,263 (42.3%) vs. 1,367 (17.9%)), coronary artery disease (1,432 (47.9%) vs. 2,481 (32.5%)), history of percutaneous coronary intervention or graft (443 (14.83%) vs. 860 (11.3%)), chronic obstructive pulmonary disease (644 (21.6%) vs. 1,131 (14.8%)) , chronic kidney disease (1,182 (39.6%) vs. 2,216 (29.0%)), and hyperlipidemia (1,828 (61.2%) vs. 4,087 (53.5%); all P < 0.05), were significantly higher in orthostatic hypotension patients with atrial fibrillation. Following multivariable analysis of orthostatic hypotension patients, atrial fibrillation was associated with 5.0 times greater odds for cardiac arrest (adjusted odds ratio (aOR) = 5.0 (95% confidence interval (CI): 1.4 -18.2), P = 0.014), without increased risk of in-hospital mortality (aOR = 2.1 (95% CI: 0.9 -5.0), P = 0.090).Conclusions: Atrial fibrillation is an independent predictor for cardiac arrest but not in-hospital mortality in patients with orthostatic hypotension. The short-and long-term prognostic value of atrial fibrillation in orthostatic hypotension patients must be confirmed in future prospective trials to improve patient outcomes.

show abstract

“…Arterial stiffness, which is considered to be one of the earliest pathophysiological processes in the progression of atherosclerosis-related metabolic diseases, is a prominent manifestation of vascular aging, and it has become an independent risk factor for atherosclerosis ( 2 ), coronary heart disease ( 3 ), diabetes ( 4 ), stroke ( 5 ), and other CVDs ( 6 , 7 ). Increased arterial stiffness or decreased vascular elasticity can impair arterial function, leading to increased systolic blood pressure, left ventricular hypertrophy, and reduced ventricular diastolic function ( 8 , 9 ), and thus increases the risk of arteriosclerosis and coronary artery disease ( 10 , 11 ).…”

Section: Introductionmentioning

confidence: 99%

The effect of aerobic exercise on pulse wave velocity in middle-aged and elderly people: A systematic review and meta-analysis of randomized controlled trials

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

A growing body of research examines the effect of aerobic exercise on pulse wave velocity (PWV) in middle-aged and elderly people, while findings of available studies were conflicting. The aim of this study was to explore the effect of aerobic exercise on PWV in middle-aged and elderly people. Searches were performed in PubMed, Web of Science, and EBSCO databases. Cochrane risk assessment tool was used to evaluate the methodological quality of the included literature. We included studies that satisfied the following criteria: (1) eligible studies should be randomized controlled trials (RCTs); (2) eligible studies should include both an intervention and a control group; (3) eligible studies should use the middle-aged or elderly people as subjects; and (4) eligible studies should use PWV as the outcome measure. From 972 search records initially identified, 11 studies with a total of 12 exercise groups (n = 245) and 11 control groups (n = 239) were eligible for meta-analysis. There was a significant effect of aerobic exercise on reducing PWV in middle-aged and elderly people [weighted mean difference (WMD), –0.75 (95% CI, –1.21 to –0.28), p = 0.002]. Specifically, a higher intensity [vigorous-intensity, –0.74 (–1.34 to –0.14), p = 0.02; moderate-intensity, –0.68 (–1.49 to 0.12), p = 0.10], a younger age [45 years ≤ age < 60 years, –0.57 (–0.78 to –0.37), p < 0.00001; age ≥ 60 years, –0.91 (–2.10 to 0.27), p = 0.13], a better health status [healthy, –1.19 (–2.06 to –0.31), p = 0.008; diseased, –0.32 (–0.64 to –0.01), p = 0.04], and a lower basal body mass index (BMI) [BMI < 25, –1.19 (–2.06 to –0.31), p = 0.008; 25 ≤ BMI < 30, –0.52 (–0.92 to –0.12), p = 0.01; BMI ≥ 30, –0.09 (–0.93 to 0.76), p = 0.84] were associatedwith larger reductions in PWV. Aerobic exercise, especially vigorous-intensity aerobic exercise, contributed to reducing PWV in middle-aged and elderly people. The effect of aerobic exercise on improving PWV was associated with characteristics of the participants. Specifically, a younger age, a better health status, and a lower basal BMI contributed to more significant reductions in PWV.Systematic review registration[https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022337103], identifier [CRD42022337103].

show abstract

Arterial stiffness and atrial fibrillation: A review

Cited by 8 publications

References 68 publications

Relationship between Arterial Stiffness and CHA2DS2-VASc Score in AF-related Stroke Patients

Relationship between Arterial Stiffness and CHA2DS2-VASc Score in AF-related Stroke Patients

Atrial Fibrillation as a Prognostic Indicator in Patients With Orthostatic Hypotension: Nationwide Inpatient Sample Analysis

The effect of aerobic exercise on pulse wave velocity in middle-aged and elderly people: A systematic review and meta-analysis of randomized controlled trials

Contact Info

Product

Resources

About