Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil

Benseñor, Isabela M.; Goulart, Alessandra Carvalho; Pereira, Alexandre C.; Brunoni, André R.; Alencar, Airlane Pereira; Santos, Raul D.; Bittencourt, Márcio Sommer; Telles, Rosa Weiss; Machado, Luciana A. C.; Barreto, Sandhi Maria; Almeida-Pititto, Bianca de; Janovsky, Carolina Castro Porto Silva; Sgarbi, José Augusto; Tebar, William Rodrigues; Meneghini, Vandrize; Barbosa, Fernando; Ribeiro, Ana Cristina de Medeiros; Pasoto, Sandra Gofinet; Pereira, Rosa Maria Rodrigues; Bonfá, Eloísa; Sipahi, Aytan Miranda; Santos, Itamar de Souza; Lotufo, Paulo A

doi:10.1016/j.clinsp.2022.100013

Cited by 1 publication

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“…Cases of psoriasis were identified according to medical diagnosis based on the participant’s report at the 8-year follow-up data collection visit ( 14 ), through the question: “Have you ever been diagnosed with psoriasis by a physician?” The positive respondents were asked to answer the second question: “What was your age at the first diagnosis of psoriasis?” This information was used to calculate disease duration by subtracting the age at diagnosis from the age of the participant at study enrollment. Spontaneous self-reported information of medical diagnosis of psoriasis was also considered for identification at baseline.…”

Section: Methodsmentioning

confidence: 99%

Eight-year change in carotid intima-media thickness and associated risk factors in adults with and without psoriasis - the ELSA-Brasil cohort study

Tebar

Santos

Meneghini

et al. 2023

Braz J Med Biol Res

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The longitudinal association between psoriasis and carotid intima-media thickness (CIMT) has not yet been established. This study aimed do compare CIMT and its change (∆CIMT) after an 8-year follow-up according to psoriasis diagnosis and the association with risk factors in the ELSA-Brasil study. Data from 7564 participants were analyzed (median age of 50.0 [44.0-57.0] years, 56.9% women). CIMT was assessed by ultrasound and ∆CIMT was calculated by subtracting baseline values from follow-up values. Psoriasis participants were identified by self-reported medical diagnosis (n=143) and compared with matched participants without disease (n=572) and with the entire sample without psoriasis (n=7421). Baseline CIMT explained the 8-year CIMT increase only in 36.9% among psoriasis participants and in ∼43.0% in participants without disease. CIMT was associated with age (β=0.002, P=0.002) and hypertension (β=0.029, P=0.034) in psoriasis participants. Among participants without psoriasis, CIMT was associated with age, male sex, low educational attainment, past smoking, obesity, diabetes, hypertension, and dyslipidemia (P<0.05). There was an inverse association of CIMT with private health insurance (β=-0.004, P=0.042) and White ethnicity (β=-0.006, P=0.004) in the entire sample without psoriasis but not in matched participants. Psoriasis participants showed an inverse association between ∆CIMT and diabetes (β=-0.214, P=0.011), while the entire sample without psoriasis showed an inverse association between ∆CIMT and age (β=-0.005, P<0.001), past smoking (β=-0.048, P=0.009), and hypertension (β=-0.048, P=0.009). In conclusion, psoriasis was not associated with CIMT after an 8-year follow-up. The inverse association of ∆CIMT with diabetes in psoriasis participants needs further clarification.

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Section: Methodsmentioning

confidence: 99%